Article
Environmental Sciences
Carlos Villaorduna, Mariano Mendoza-Carlos, Manuel Chuyma, Jhon Aviles, Ayda Avalos-Diaz, Ronald Lozano-Reategui, Juan Garcia-Ruiz, Nadia Panduro-Tenazoa, Jessy Vargas, Ysabel Moran-Quintanilla, Jose-Luis Rodriguez
Summary: Ipconazole, an antifungal agrochemical, poses a hazard to human, animal, and environmental health due to its widespread use in agriculture and easy accumulation in the environment. Our study investigated the cytotoxic effects of ipconazole on SH-SY5Y neuroblastoma cells, revealing a dose-dependent reduction in cell viability, increased ROS production, and induction of cell death. These findings suggest that ipconazole exposure may contribute to neurotoxicity or neurodegeneration.
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Dong Kwon Yang
Summary: Parkinson's disease is a neurodegenerative disorder with limited treatment options. Sinapic acid has shown potential as a neuroprotective agent against oxidative stress, mitochondrial dysfunction, and apoptosis, suggesting promising effects in the prevention and treatment of PD.
Article
Nutrition & Dietetics
Chia-Ling Ho, Ning-Jo Kao, Ching- Lin, Tzu-Wen L. Cross, Shyh-Hsiang Lin
Summary: Alzheimer's disease is a common neurodegenerative disorder, with oxidative stress and mitochondrial biogenesis being implicated in its progression. Quercetin has been found to increase mitochondrial biogenesis and reduce oxidative stress-induced damage, showing promise in protecting neuronal cells.
Article
Biochemistry & Molecular Biology
Vincenzo Vestuto, Giuseppina Amodio, Giacomo Pepe, Manuela Giovanna Basilicata, Raffaella Belvedere, Enza Napolitano, Daniela Guarnieri, Valentina Pagliara, Simona Paladino, Manuela Rodriquez, Alessia Bertamino, Pietro Campiglia, Paolo Remondelli, Ornella Moltedo
Summary: This study demonstrates the neuroprotective effects of cocoa extract and its purified fractions in a cellular model of Parkinson's disease. The cocoa extract targets the PERK sensor, showing significant antioxidant and antiapoptotic activities. Additionally, cocoa inhibits the accumulation of alpha-synuclein in the cells.
Article
Food Science & Technology
Raquel Penalva-Olcina, Cristina Juan, Monica Fernandez-Franzon, Ana Juan-Garcia
Summary: Beetroot extract (BRE) has a cytoprotective effect on neuroblastoma cells exposed to Fumonisin B1 (FB1) and ochratoxin A (OTA), with better protection observed in the pretreatment strategy.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Domenico Nuzzo, Miriana Scordino, Antonino Scurria, Costanza Giardina, Francesco Giordano, Francesco Meneguzzo, Giuseppa Mudo, Mario Pagliaro, Pasquale Picone, Alessandro Attanzio, Stefania Raimondo, Rosaria Ciriminna, Valentina Di Liberto
Summary: IntegroPectin from grapefruit shows strong antioxidant and antiproliferative effects, making it a potential therapeutic agent for oxidative stress-associated brain disorders and cancer. Further studies on its molecular mechanisms are urgently needed to fully explore its therapeutic and preventive potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rugmani Meenambal, Tomasz Kruk, Jacek Gurgul, Piotr Warszynski, Danuta Jantas
Summary: In this study, PAA-CeO nanoparticles were synthesized and found to have neuroprotective effects against cell damage induced by H2O2 and 6-OHDA, reducing necrotic changes and partially attenuating caspase-3 activity. However, there was no impact on ROS formation induced by H2O2.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Xueyang Xiao, Zhou Tong, Yuexing Zhang, Hui Zhou, Mengying Luo, Tianhui Hu, Ping Hu, Luqi Kong, Zeqin Liu, Chan Yu, Zhiyong Huang, Linzhen Hu
Summary: Two novel prenylated indole alkaloids, asperpenazine and asperpendoline, exhibit potential neuroprotective activity against oxidative stress in Parkinson's disease. Asperpendoline inhibits Keap1 expression, promoting the translocation of Nrf2 to the nucleus and the expression of downstream genes, leading to a reduction in reactive oxygen species and an increase in glutathione levels.
Article
Biochemistry & Molecular Biology
Chaemoon Lim, Ao Xuan Zhen, Sungwoo Ok, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyun
Summary: This study found that hesperidin can inhibit high glucose-induced apoptosis and mitigate oxidative stress and endoplasmic reticulum stress. It also promotes cell survival through modulation of the mitogen-activated protein kinase signaling pathway.
Article
Environmental Sciences
Luis Barrios-Arpi, Yurie Arias, Bernardo Lopez-Torres, Mariella Ramos-Gonzalez, Giulio Ticli, Ennio Prosperi, Jose-Luis Rodriguez
Summary: Flumethrin, a synthetic pyrethroid, induces neurotoxicity through oxidative stress and apoptosis. This study provides evidence for the cytotoxicity effects, oxidative stress markers, and apoptosis-related gene expressions associated with flumethrin exposure.
Article
Plant Sciences
Haoqi Liu, Na An, Liqin Wang, Yuanyuan Li, Ke Song, Yikun Sun, Yonghong Gao
Summary: This study explored the potential mechanism of Xingnaojing injection in cerebral ischemia by studying its effect on ferroptosis. The results showed that XNJ could promote the recovery of neurological function in MCAO rats and hypoxia-damaged cells by regulating ferroptosis-related proteins.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Yu Shang, Wanlei Xue, Jiexing Kong, Yingjun Chen, Xinghua Qiu, Xingqin An, Yi Li, Hongli Wang, Jing An
Summary: This study found that exposure to ambient ultrafine black carbon causes mitochondrial oxidative stress, leading to mitochondrial dysfunction and neurotoxicity. Regulation of mitophagy process can mitigate mitochondrial damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Ezgi Oztas, Mehtap Kara, Tugce Boran, Enes Bisirir, Ecem Fatma Karaman, Engin Kaptan, Gul Ozhan
Summary: Acetamiprid, a widely used neonicotinoid insecticide, has been found to be associated with neurological symptoms and cell death in neural cells by increasing cellular stress and promoting apoptosis. Additional studies are needed to fully understand its molecular mechanisms and the potential harm it may cause to mammals.
Article
Biochemistry & Molecular Biology
Fangfang Tie, Yangyang Fu, Na Hu, Honglun Wang
Summary: The present study demonstrated that silibinin attenuated H2O2-induced oxidative stress by regulating Nrf2 signaling and improving mitochondrial function in human neuroblastoma cells. This suggests that silibinin could be a potential candidate for preventing neurodegenerative diseases.
Article
Endocrinology & Metabolism
Yang Mu, Beiqiang Deng, Zhiwen Yang, Chunxiang li, Juan Xia
Summary: This study explored the effects of Dexmedetomidine (DEX) and lidocaine on neuronal cell apoptosis. The findings indicate that DEX can attenuate cell apoptosis induced by lidocaine by regulating mitochondrial biogenesis, reducing reactive oxygen species (ROS) production, and preventing a decline in mitochondrial membrane potential.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Emilene A. Nunes, Tania M. Manieri, Andreza C. Matias, Fernanda R. Bertuchi, Daniela A. da Silva, Larissa Lago, Roseli H. Sato, Giselle Cerchiaro
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2018)
Article
Toxicology
Fernanda S. de Sousa, Emilene A. Nunes, Kaio S. Gomes, Giselle Cerchiaro, Joao Henrique G. Lago
TOXICOLOGY IN VITRO
(2019)
Article
Pharmacology & Pharmacy
Cibele Nicolaski Pedron, Cyntia Silva de Oliveira, Adriana Farias da Silva, Gislaine Patricia Andrade, Maria Aparecida da Silva Pinhal, Giselle Cerchiaro, Pedro Ismael da Silva Junior, Fernanda Dias da Silva, Marcelo Der Torossian Torresd, Vani Xavier Oliveira
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Chemistry, Inorganic & Nuclear
Luiz D. Ramos, Giselle Cerchiaro, Karina P. Morelli Frin
INORGANICA CHIMICA ACTA
(2020)
Review
Biochemistry & Molecular Biology
Fabio C. Coelho, Rosanna Squitti, Mariacarla Ventriglia, Giselle Cerchiaro, Joao P. Daher, Jaidson G. Rocha, Mauro C. A. Rongioletti, Anna-Camilla Moonen
Article
Biotechnology & Applied Microbiology
Marcelo D. T. Torres, Adriana F. Silva, Gislaine P. Andrade, Cibele N. Pedron, Giselle Cerchiaro, Anderson O. Ribeiro, Vani X. Oliveira Jr, Cesar de la Fuente-Nunez
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2020)
Article
Chemistry, Inorganic & Nuclear
Julia F. Mamud, Giovanna Biazolla, Caroline S. Marques, Giselle Cerchiaro, Thiago B. de Queiroz, Artur F. Keppler, Andre S. Polo
Summary: A series of rhenium(I) polypyridyl compounds with photoisomerizable nitrones as ligands were synthesized and characterized, and their photochemical and photophysical behaviors were investigated. It was found that the photoisomerization of coordinated nitrones resulted in an increase in emission intensity, which has potential applications in the development of molecular devices such as photosensors.
INORGANICA CHIMICA ACTA
(2021)
Article
Cell Biology
Caroline M. S. Marques, Tatiana Pedron, Bruno L. Batista, Giselle Cerchiaro
Summary: The cellular prion protein (PrP(C)) plays an important role in cellular defense mechanisms and metal homeostasis in astrocytes cells, regulating apoptosis cell death and healthy growth.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Fabio Cunha Coelho, Giselle Cerchiaro, Sheila Espirito Santo Araujo, Joao Paulo Lima Daher, Silvia Almeida Cardoso, Gustavo Fialho Coelho, Arthur Giraldi Guimaraes
Summary: Alzheimer's disease and other forms of dementia ranked third in global causes of death and disability in 2019. Imbalance of copper and molybdenum has been associated with the occurrence of Alzheimer's disease, possibly due to its impact on sulfur metabolism. This review provides an updated discussion on the mechanisms involving copper, sulfur, and molybdenum alterations in Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Amit Pal, Giselle Cerchiaro, Isha Rani, Mariacarla Ventriglia, Mauro Rongioletti, Antonio Longobardi, Rosanna Squitti
Summary: The review discusses the role of reactive oxygen species (ROS) in neurodegeneration and highlights the importance of transition metals in Alzheimer's disease (AD) pathogenesis. It emphasizes the essential function of iron in the body while warning about the potential risks of its dysfunction and accumulation in relation to AD.
Article
Pharmacology & Pharmacy
Bianca de Melo Santana, Joana Claudio Pieretti, Rafael Nunes Gomes, Giselle Cerchiaro, Amedea Barozzi Seabra
Summary: Combining nitric oxide (NO) donor and silica nanoparticles loaded with cisplatin into a polymeric matrix can create a drug-delivery system that provides sustained and localized drug release against tumor cells.
Article
Chemistry, Multidisciplinary
Eliana M. A. Valle, Vinicius G. Maltarollo, Thiago C. Princhak, Kathia M. Honorio, Giselle Cerchiaro
Summary: This study investigated the affinity of Cu-II by three ligands of biological interest and found that Cu-II showed a higher affinity for the Et2DTC ligand compared to the TPEN and TRIEN ligands. Theoretical calculations and electrochemical studies were used to determine the binding energy and oxidation peaks of Cu-II complexed with the different ligands. The results demonstrated the varying affinities of Cu-II for the different ligands studied.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Tania M. Manieri, Stefano L. Sensi, Rosanna Squitti, Giselle Cerchiaro
Summary: The study altered the activity of SOD1 in AD patients by modifying its zinc complexation capacity, leading to decreased enzymatic activity even when complexed with copper. The mutant SOD1 presented instability in zinc and copper coordination, making it a valuable in vitro model for studying SOD1 behavior in AD patients.
Article
Chemistry, Inorganic & Nuclear
Luiz D. Ramos, Leonardo H. de Macedo, Nicholas R. S. Gobo, Kleber T. de Oliveira, Giselle Cerchiaro, Karina P. Morelli Frin
DALTON TRANSACTIONS
(2020)
Proceedings Paper
Nanoscience & Nanotechnology
I. M. Lourenco, M. T. Pelegrino, J. C. Pieretti, G. P. Andrade, G. Cerchiaro, A. B. Seabra
6TH NANOSAFE INTERNATIONAL CONFERENCE
(2019)
