Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 555, Issue -, Pages 82-93Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.07.061
Keywords
Charge-reversal; Control release; Morpholino; Hydrazone
Categories
Funding
- National Natural Science Foundation of China [21776101, 21808039]
- Fundamental Research Funds for the Central Universities, China [2019PY29]
- Research Fund Program of Guangdong Provincial Key Lab of Green Chemical Product Technology [GC201807]
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This study introduced multistage pH-responsive nanohybrids (MSN-hyd-MOP) based on mesoporous silica nanoparticles (MSNs) modified with polymers with charge-reversal property via an acid-labile hydra zone linker, which were applied as a drug delivery system loaded anticancer drugs. In this study, MSN-hyd-MOP nanohybrids were completely investigated for their synthesis, pH response, drug release behavior, cytotoxicity capability and endocytic behavior. Responding to the acidic extracellular microenvironment of solid tumor (pH 6.5), MSN-hyd-MOP nanohybrids exhibited surface charge-reversal characteristic from negative (-10.2 mV, pH 7.4) to positive (16.6 mV, pH 6.5). The model drug doxorubicin (Dox) was efficiently loaded within the channels of MSN-hyd-MOP (encapsulation efficiency about 87%). The increased acidity in endo-/lysosome promote Dox-loaded MSN-hyd-MOP (MSN-hyd-MOP@Dox) release Dox quickly. In vitro study revealed the drug delivery system had good biocompatibility and could deliver the payload to tumor cells. Overall, the described nanohybrids can be used as a potential anticancer drug delivery system. (C) 2019 Elsevier Inc. All rights reserved.
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