Article
Biochemistry & Molecular Biology
Mahnoosh Aliahmadi, Akbar Esmaeili
Summary: This study synthesized new modified imaging nanocapsules containing Morus nigra extract by selenium nanoparticles prepared from Lactobacillus acidophilus. The antibacterial activities of the modified contrast agents were investigated, and the influence of various factors on the activity was studied. The structure and morphology of the synthesized contrast agents were characterized using multiple techniques.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Azam Ahmadi, Parisa Ahmadi, Mahmood Alizadeh Sani, Ali Ehsani, Babak Ghanbarzadeh
Summary: Bio-nanocomposite films were fabricated from gelatin and cellulose nanofibers with the addition of zinc oxide and/or selenium nanoparticles, enhancing the mechanical and barrier properties of the films and showcasing antibacterial and antioxidant features. The combination of Se nanoparticles and ZnO nanoparticles improved the antioxidant effect of the films, making them suitable for active food packaging products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Fan -Bing Meng, Yu -Ting Lei, Qing-Zhou Li, Yun-Cheng Li, Yun Deng, Da -Yu Liu
Summary: This study found that fermentation by two lactic acid bacteria strains, L. plantarum and L. acidophilus, significantly improved the antioxidant activity of loquat juice. Metabolomics analysis revealed different metabolites profiles between the two strains, with lipids, organic acids, amino acids, and phenolic compounds playing important roles in the flavor reconstruction and functional improvement of loquat juices.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Diletta Francesca Squarzanti, Paola Zanetta, Margherita Ormelli, Marcello Manfredi, Elettra Barberis, Virginia Vita Vanella, Angela Amoruso, Marco Pane, Barbara Azzimonti
Summary: The spread of multidrug-resistant bacteria is a global health challenge and there is an urgent need for new methods to counteract opportunistic pathogen growth. In this study, the activity of cell-free supernatants (CFSs) produced by two strains of bacteria was compared. The CFS from one strain grown in an innovative animal derivative-free broth showed the highest efficacy in inhibiting the growth of the multidrug-resistant Staphylococcus aureus, indicating its potential as a bacteriotherapeutic and bio-repair agent.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Rachael M. Wilson, Jean M. Walker, Kingsley Yin
Summary: Probiotics like Lactobacillaceae strains show antimicrobial and immunomodulatory activity. CFF derived from different concentrations of live Lactobacillus acidophilus inhibit biofilm formation and possess varying effects on immune cells, with high concentration CFF inducing NF-kappa B expression and TNF alpha production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Arif Jamal Siddiqui, Mitesh Patel, Mohd Adnan, Sadaf Jahan, Juhi Saxena, Mohammed Merae Alshahrani, Abdelmushin Abdelgadir, Fevzi Bardakci, Manojkumar Sachidanandan, Riadh Badraoui, Mejdi Snoussi, Allal Ouhtit
Summary: The objective of this study was to synthesize bacteriocin-derived silver nanoparticles (Bac10307-AgNPs) from Lactobacillus acidophilus (L. acidophilus) to enhance the bioactivity of bacteriocins and overcome their commercial limitations. The synthesized Bac10307-AgNPs showed strong antibacterial activity, promising antioxidant activity, and cytotoxicity against human liver cancer cells.
Article
Food Science & Technology
Binbin Li, Dandan Yuan, Shengguo Song, Mingwei Yang, Guilan Jiang, Yuting Song, Zhuhong Ding
Summary: Lactobacillus acidophilus GIM1.208 (LA) can significantly improve the volatile flavor and sensory scores of Rosa rox-burghii Tratt (RRT). This study used widely targeted metabolomics to comprehensively analyze the effects of LA on flavor and activity of RRT. The results showed that LA fermentation increased the total phenolics and flavonoids content of RRT, while slightly decreasing the total triterpenoids content. The total antioxidant activity and hypoglycemic activity of RRT also increased.
Article
Green & Sustainable Science & Technology
Seyed Amirebrahim Emami Moghaddam, Parinaz Ghadam, Fatemeh Rahimzadeh
Summary: This study successfully biosynthesized high-quality cadmium sulfide nanoparticles using the aqueous extract of Lactobacillus acidophilus and improved the biosynthesis process using response surface methodology.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Microbiology
Haibin Lu, Xueyang Zhang, Shakeel Ahmad Khan, Wenqiang Li, Lei Wan
Summary: In this study, manganese dioxide nanoparticles were successfully synthesized using plant extract as reducing and capping agents, demonstrating excellent antibacterial, antifungal, biofilm inhibition, and antioxidant properties, along with good biocompatibility with cells. Compared to chemically synthesized nanoparticles, the synthesized nanoparticles exhibited higher biomedical activities, indicating the potential for novel eco-friendly nanomaterial fabrication with enhanced medicinal functions from herbal origins.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Sentkowska, Krystyna Pyrzynska
Summary: Selenium nanoparticles have unique properties and potential bioactivities. This study found that the antioxidant activity of selenium nanoparticles is not only dependent on their size but also on their homogeneity, and the clean-up step can control the size and morphology of selenium nanoparticles.
Article
Microbiology
Longxian Lv, Chunyan Yao, Ren Yan, Huiyong Jiang, Qiangqiang Wang, Kaicen Wang, Siqi Ren, Shandong Jiang, Jiafeng Xia, Shengjie Li, Ying Yu
Summary: The probiotic Lactobacillus acidophilus LA14 showed protective effects on liver injury induced by D-galactosamine in rats, alleviating serum markers, histological damage, and inflammatory cytokine levels. It modulated gut microbiota, metabolism, and hepatic gene expression. Moreover, confirmation of its ability to alleviate liver injury in acetaminophen-induced mouse model suggests a potential application in liver injury prevention.
Article
Chemistry, Inorganic & Nuclear
Soyoung Park, Kandasamy Saravanakumar, Xin Zhang, Myeong Seon Jeong, Myeong-Hyeon Wang
Summary: The present work prepared and characterized tetracycline-loaded, Lactobacillus rhamnosus GG extract mediated ZrO2 NPs with improved antibacterial activity. The results showed that TCH-ZrO2 NPs exhibited strong antimicrobial activity against drug-resistant bacteria without significant toxicity to cells and chicken embryos.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biophysics
Fu-Cen Luo, Jing-Jing Zhu, Xin-Meng You, Xiao-Quan Yang, Shou-Wei Yin
Summary: Oxidative stress caused by environmental exposures can lead to various skin diseases. We report a method for generating a core-shell nanostructure (G-LSS) by growing a sericin crust around a gliadin nanoparticle as a topical nanocarrier for PHL to improve its cutaneous bioavailability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Ying Xu, Ting Zhang, Jiarui Che, Jiajia Yi, Lina Wei, Hongliang Li
Summary: Selenium nanoparticles (SeNPs) can be synthesized by Lactobacillus casei ZK-AS 1.1482 and have antimicrobial activity against Pseudomonas fluorescens. The synthesized SeNPs were amorphous with sizes ranging from 52 to 103 nm and were stabilized by proteins, polysaccharides, and lipids on the surface. SeNPs inhibited the growth of P. fluorescens by decreasing the number of living bacteria and altering cellular functions. The expression of specific genes related to cell membrane integrity was affected by SeNPs treatment. Biogenic SeNPs have the potential to be used as a novel antimicrobial agent in the food industry.
Article
Biotechnology & Applied Microbiology
Luting Weng, Lang Wu, Rongjuan Guo, Jiajia Ye, Wen Liang, Wei Wu, Liang Chen, Deqin Yang
Summary: This study successfully prepared nanoparticles, called LA/TCS@PLGA-NPs, with favorable properties using cell membrane coating technology and Lactobacillus strains. The nanoparticles were able to adhere to Streptococcus mutans and interfere with its biofilm formation, leading to significant inhibition of the activity, biomass, and virulence gene expression of the biofilms. In vivo experiments also showed that LA/TCS@PLGA-NPs had a long-lasting inhibitory effect on the progression of dental caries. These nanoparticles could be considered as a new class of effective drug delivery systems for caries prevention.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Hamed Barabadi, Alireza Mohammadzadeh, Hossein Vahidi, Masoumeh Rashedi, Muthupandian Saravanan, Niloufar Talank, Ahad Alizadeh
Summary: This study evaluated the antibacterial and biofilm inhibitory activity of Penicillium chrysogenum-derived silver nanoparticles (AgNPs) against Acinetobacter baumannii. AgNPs showed significant biofilm inhibitory effects, with higher potency against some pathogenic strains in inhibiting biofilm formation compared to tetracycline. Further in vivo studies are needed to assess the biofilm inhibitory efficacy of biogenic AgNPs.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kunal Biswas, Awdhesh Kumar Mishra, Pradipta Ranjan Rauta, Abdullah G. Al-Sehemi, Mehboobali Pannipara, Avik Sett, Amra Bratovcic, Satya Kumar Avula, Tapan Kumar Mohanta, Muthupandian Saravanan, Yugal Kishore Mohanta
Summary: The potential role of AgNPs/endo-fullerene molecule metal nano-composite has been evaluated in vitro. The fullerene molecule (C-60) has shown anti-proliferative activity against breast adenocarcinoma cell lines and antimicrobial activity against human pathogens. The unique electronic and physico-chemical properties of the fullerene molecules raise hope for drug delivery applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shanmugam Dilip Kumar, Manimaran Aashabharathi, Guruviah Karthiga Devi, Ramasamy Subbaiya, Muthupandian Saravanan
Summary: Regenerative medicine using stem cells to rejuvenate tissues and organs can be greatly enhanced with the integration of CRISPR-Cas technology, allowing for customized DNA/RNA sequences and diverse applications in genomic editing and transcriptional regulation.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dhivya Elangovan, Haajira Beevi Habeeb Rahman, Ranjithkumar Dhandapani, Velmurugan Palanivel, Sathiamoorthi Thangavelu, Ragul Paramasivam, Saravanan Muthupandian
Summary: The study investigated the antifungal activity of silver nanoparticles synthesized using Passiflora foetida fruit extract against indoor fungus Fusarium sp. The nanoparticles displayed excellent antifungal activity when coated in wallpaper, showing potential for controlling indoor fungi.
PROCESS BIOCHEMISTRY
(2022)
Article
Microbiology
Faheem Mustafa, Hitesh Chopra, Atif Amin Baig, Satya Kumar Avula, Sony Kumari, Tapan Kumar Mohanta, Muthupandian Saravanan, Awdhesh Kumar Mishra, Nanaocha Sharma, Yugal Kishore Mohanta
Summary: Obesity is a global health issue that leads to chronic diseases. Conventional treatments have limitations, and recent research has explored the role of dietary factors, particularly edible mushrooms and their bioactive compounds, in preventing obesity and other chronic ailments.
Article
Biochemistry & Molecular Biology
D. Balakrishnan, C. Pragathiswaran, K. Thanikasalam, Yugal Kishore Mohanta, Muthupandian Saravanan, Magda H. Abdellattif
Summary: In this study, a nanocomposite based on polyaniline and zinc oxide was developed using nanotechnology. The results showed that the nanocomposite has the ability to inhibit the growth of kidney stones, indicating its potential applications in kidney diseases.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Review
Biochemical Research Methods
Haajira Beevi Habeeb Rahuman, Ranjithkumar Dhandapani, Santhoshini Narayanan, Velmurugan Palanivel, Ragul Paramasivam, Ramalakshmi Subbarayalu, Sathiamoorthi Thangavelu, Saravanan Muthupandian
Summary: The search for alternative medicine to combat antibiotic resistance has led to a growing interest in metallic nanoparticles, particularly silver nanoparticles. This review provides a comprehensive understanding of the pharmaceutical qualities of medicinal plants and serves as a convenient guideline for plant-based silver nanoparticles and their antimicrobial activity.
IET NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bruno S. Lopes, Alfizah Hanafiah, Ramesh Nachimuthu, Saravanan Muthupandian, Zarith Nameyrra Md Nesran, Sandip Patil
Summary: Antibiotic resistance caused by ESKAPE pathogens resulted in more than one million deaths globally in 2019. The use of antimicrobial peptides (AMPs) is crucial in combating this crisis, but their stability and potential toxic side effects need to be addressed. Developing new AMP analogues and using a one health approach, along with phage therapies and breakthroughs in antimicrobial peptide synthesis, can help tackle the problem of antimicrobial resistance (AMR).
Article
Cell Biology
Yugal Kishore Mohanta, Awdhesh Kumar Mishra, Debasis Nayak, Biswajit Patra, Amra Bratovcic, Satya Kumar Avula, Tapan Kumar Mohanta, Kadarkarai Murugan, Muthupandian Saravanan
Summary: Green-based synthesis of silver nanoparticles using marine seaweed Gracilaria edulis shows potential for applications in various industries including food preservative film industry, biomedical, and pharmaceutical industries due to its antioxidant, anticancer, and antimicrobial activities.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Prathapavarma Digala, Muthupandian Saravanan, Manoj Dhanraj, Jayakrishna Pamarthi, Suganthi Muralidharan, Akhila Narikimelli, K. P. Dinakaran, Selvaraj Arokiyaraj, Savaraiar Vincent
Summary: In this study, the extraction of water-soluble crude sulfated polysaccharide (WSCSP) from Sargassum polycystum was optimized and its biological activity was investigated. Acid hot water extraction resulted in a high WSCSP yield and the polysaccharide showed antioxidant activity, promoted wound healing, and demonstrated significant cytotoxicity against cervical cancer cells.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Ranjithkumar Dhandapani, Sathiamoorthi Thangavelu, Latha Ragunathan, Ragul Paramasivam, Palanivel Velmurugan, Saravanan Muthupandian
Summary: Antimicrobial resistance has become a major concern worldwide, and this study identified a potentially active strain (Streptomyces sp. SRMA3) with antimicrobial activity against drug-resistant clinical pathogens. The active metabolite derived from this strain showed good antibacterial and antibiofilm activity, suggesting its potential for various biotechnological applications.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Arun Chandra Manivannan, Ranjithkumar Dhandapani, Palanivel Velmurugan, Sathiamoorthi Thangavelu, Ragul Paramasivam, Latha Ragunathan, Muthupandian Saravanan
Summary: This article discusses the use of bacteriophages in cancer treatment, including the therapeutic mechanisms and the process of screening tumor attacking peptides. Bacteriophages are effective vehicles for delivering peptides to target tumors. This therapeutic method is significant in cancer detection, diagnostics, and treatment.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Medicine, General & Internal
Yasasve Madhavan, Kadambari Vijay Sai, Dilip Kumar Shanmugam, Aashabharathi Manimaran, Karthigadevi Guruviah, Yugal Kishore Mohanta, Divyambika Catakapatri Venugopal, Tapan Kumar Mohanta, Nanaocha Sharma, Saravanan Muthupandian
Summary: Mucormycosis, also known as COVID-19 associated mucormycosis (CAM), is increasingly associated with COVID-19 and poses challenges in treatment due to antifungal resistance and underlying comorbidities. Early diagnosis, reversal of risk factors, and a multifaceted treatment strategy are critical in controlling this invasive fungal infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Pharmacology & Pharmacy
Balakumar Chandrasekaran, Muthupandian Saravanan
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Abhinav Prasad, Ashapurna Khatua, Yugal Kishore Mohanta, Muthupandian Saravanan, Ramovatar Meena, Ilora Ghosh
Summary: This study demonstrates the effectiveness of a combination therapy using low-dose gold nanoparticles and glutamine deprivation in inhibiting the growth of human cervical cancer cells. The combination treatment resulted in significant inhibition of cell growth and induced cellular uptake of nanoparticles. The therapy also induced oxidative stress conditions and mitochondrial inactivity in the cancer cells.
