Review
Physiology
Xiatian Chen, Chengzhen Shi, Yin Wang, Hua Yu, Yu Zhang, Jiaxuan Zhang, Peifeng Li, Jinning Gao
Summary: Patients with diabetes often experience severe vascular complications, which are influenced by glycolipid metabolism disorder. Hyperglycemia and hyperlipidemia trigger inflammation and oxidative stress, leading to endothelial dysfunction and vascular damage. Additionally, epigenetic modifications play a role in the pathogenesis of diabetes.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jinjoo Lee, Seungjin Noh, Suhyun Lim, Bonglee Kim
Summary: Type 2 diabetes mellitus is a major global public health issue, with plant extracts being a potential therapeutic agent due to their antidiabetic effects and fewer side effects. These extracts regulate blood glucose, possess anti-inflammatory and antioxidant properties, and can alleviate complications caused by insulin resistance through various pathways.
Review
Nutrition & Dietetics
Jessica Lewgood, Barbara Oliveira, Marie Korzepa, Scott C. Forbes, Jonathan P. Little, Leigh Breen, Robert Bailie, Darren G. Candow
Summary: The prevalence of Type 2 diabetes (T2D) is increasing and creating a large economic burden. This review critically evaluates the effects of various dietary strategies on diabetes management as well as examines several purported supplements aiming to improve glucose control and body composition.
Review
Nutrition & Dietetics
Jiuxiang Zhao, Hong Zou, Yanling Huo, Xiaoyi Wei, Yu Li
Summary: Selenium is an essential element for human health and mainly enters the body through diet. It plays a key role in selenoproteins, which have important biological functions including antioxidant and anti-inflammatory effects. Some selenoproteins are known to be involved in the regulation of type 2 diabetes. However, the relationship between selenium and type 2 diabetes is complex and still uncertain.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Philip Weber, Mads N. N. Thomsen, Mads Juul Skytte, Amirsalar Samkani, Martin Hansen Carl, Arne Astrup, Jan Frystyk, Jens J. J. Holst, Bolette Hartmann, Sten Madsbad, Faidon Magkos, Thure Krarup, Steen B. B. Haugaard
Summary: In a real-life setting, the benefits of a fully provided, hypocaloric, carbohydrate-reduced high-protein diet were not maintained when individuals with type 2 diabetes switched to self-prepared diets aiming for the same nutritional goals for 6 months.
Article
Nutrition & Dietetics
Jinjun Li, Huimin Yuan, Zhiqi Zhao, Li Li, Xiaoqiong Li, Liying Zhu, Xin Wang, Ping Sun, Yinping Xiao
Summary: The study demonstrates that isorhamnetin improves the symptoms of type 2 diabetes mellitus in mice, possibly through the mediation of gut microbiota. The gut microbiota is found to be significantly correlated with inflammatory factors, blood lipids, and short chain fatty acids.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Mengna Zheng, Han Yu, Yong Xue, Tong Yang, Qiufen Tu, Kaiqing Xiong, Daihua Deng, Lei Lu, Nan Huang
Summary: The study found that drinking hydrogen-rich water can suppress the increase in glucose, total cholesterol, oxidative stress, and inflammation in type 2 diabetes mellitus rats. Additionally, it can also improve hyperglycemia-induced dysfunction in the liver, kidney, and spleen.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Magnus F. G. Grondahl, Asger Lund, Jonatan Bagger, Tonny S. Petersen, Nicolai J. Wewer Albrechtsen, Jens J. Holst, Tina Vilsboll, Mikkel B. Christensen, Filip K. Knop
Summary: Impaired glucagon clearance is not a fundamental cause of hyperglucagonemia in obesity and type 2 diabetes. Body weight and fasting plasma glucose may be associated with glucagon metabolism.
Article
Pharmacology & Pharmacy
Abdelrahim Alqudah, Mohammed Wedyan, Esam Qnais, Hassan Jawarneh, Lana McClements
Summary: The study found changes in the levels of certain amino acids in patients with type 2 diabetes, with some essential amino acids increased and some non-essential amino acids decreased. These amino acids were shown to be correlated with the patients' blood glucose and HbA1c levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Kun Lu, Tingqing Yu, Xinyi Cao, Hui Xia, Shaokang Wang, Guiju Sun, Liang Chen, Wang Liao
Summary: This study investigated the effect of viscous dietary fiber on glucose and lipid metabolism in patients with type 2 diabetes mellitus. The results showed that supplementation of viscous dietary fiber is beneficial in controlling blood glucose and blood lipid levels in patients with type 2 diabetes.
FRONTIERS IN NUTRITION
(2023)
Article
Veterinary Sciences
Yuzuru Iizuka, Hyounju Kim, Maki Nakasatomi, Akiyo Matsumoto, Jun Shimizu
Summary: Research on preventing and treating age-related metabolic diseases is crucial due to the aging population. The use of elderly diabetic mouse models, such as the male KK mice, can be beneficial in studying the deterioration of glucose and lipid metabolism. However, the utility of KK mice as models for studying aging related to obesity and diabetes is unclear. This study investigates age-related changes in glucose and lipid metabolism in male KK mice fed a standard diet and suggests the need to induce deterioration in these mice through breeding with high-sucrose or high-fat diets in order to create a more useful elderly obese and diabetic animal model.
EXPERIMENTAL ANIMALS
(2022)
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Daniel C. Parker, Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, Steve Shea, Gregory L. Burke, David R. Jacobs, Wendy Post, David Corcoran, Ina Hoeschele, John S. Parks, Yongmei Liu
Summary: miRNAs play a role in the occurrence and development of type 2 diabetes (T2D) and are also associated with lipid levels.
Article
Medicine, General & Internal
Iuliia Azarova, Elena Klyosova, Alexey Polonikov
Summary: This study investigated the relationship between RAC1 gene polymorphisms and the risk and pathogenesis of T2D, identifying potential genetic markers and redox balance changes associated with the disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Josephine H. Li, Lukasz Szczerbinski, Adem Y. Dawed, Varinderpal Kaur, Jennifer N. Todd, Ewan R. Pearson, Jose C. Florez
Summary: Individuals with a higher genetic burden for T2D experience a greater acute and sustained response to sulfonylureas, suggesting potential for targeted pharmacologic intervention.
Article
Allergy
Stephanie Musiol, Carla P. Harris, Ruth Karlina, Johanna M. Gostner, Birgit Rathkolb, Benjamin Schnautz, Evelyn Schneider, Lisa Mair, Ernesto Elorduy Vergara, Claudia Flexeder, Sibylle Koletzko, Carl-Peter Bauer, Tamara Schikowski, Dietrich Berdel, Andrea von Berg, Gunda Herberth, Jan Rozman, Martin Hrabe de Angelis, Marie Standl, Carsten B. Schmidt-Weber, Siegfried Ussar, Francesca Alessandrini
Summary: This study investigated the association between starch, sucrose, and fat in relation to allergic sensitization and asthma prevalence in humans, as well as their underlying mechanisms using mouse models. The findings suggest that high consumption of digestible carbohydrates is associated with an increased prevalence of asthma in humans and aggravated lung allergic inflammation in mice, involving oxidative stress-related mechanisms.
Article
Biology
Justine Chee, Louise Lanoue, Dave L. Clary, Kendall Higgins, Lynette Bower, Ann Flenniken, Ruolin Guo, David Adams, Fatima Bosch, Robert E. Braun, Steve D. M. Brown, H. -J. Genie Chin, Mary Dickinson, Chih-Wei Hsu, Michael Dobbie, Xiang Gao, Sanjeev Galande, Anne Grobler, Jason Heaney, Yann Herault, Martin Hrabe de Angelis, Fabio Mammano, Lauryl M. J. Nutter, Helen Parkinson, Chuan Qin, Toshi Shiroishi, Radislav Sedlacek, J-K Seong, Ying Xu, Brian Brooks, Colin McKerlie, K. C. Kent Lloyd, Henrik Westerberg, Ala Moshiri
Summary: This study identified new genes and pathways associated with eye development through screening of mouse genes. These findings provide insights into the molecular and cellular mechanisms of eye development and could potentially contribute to the diagnosis and treatment of congenital blinding diseases.
Article
Biochemistry & Molecular Biology
Grace Png, Raffaele Gerlini, Konstantinos Hatzikotoulas, Andrei Barysenka, N. William Rayner, Lucija Klaric, Birgit Rathkolb, Juan A. Aguilar-Pimentel, Jan Rozman, Helmut Fuchs, Valerie Gailus-Durner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Claus Pietrzik, James F. Wilson, Martin Hrabe Angelis, Christoph Becker-Pauly, Arthur Gilly, Eleftheria Zeggini
Summary: In this study, a protein quantitative trait locus (pQTL) analysis was performed on two Greek cohorts, identifying 301 independently associated pQTL variants for 170 proteins related to cardiometabolic processes. The study also discovered rare variants and observed changes in frequency of certain pQTL variants in the isolated populations. Additionally, the study identified proteins causally associated with cardiometabolic traits and described a knock-out Mep1b mouse model.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Lillian Garrett, Dietrich Truembach, Nadine Spielmann, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe De Angelis, Sabine M. Hoelter
Summary: Neuropsychiatric diseases represent a significant global disease burden and require innovative approaches for pathogenic understanding, biomarker identification, and therapeutic strategies. The malfunction of the heart/brain axis, particularly through the autonomic nervous system and brain central autonomic network interaction, plays a crucial role in the etiology of these diseases. This inter-relationship offers potential avenues for novel diagnosis and treatment approaches.
Article
Biochemistry & Molecular Biology
Miriam Hoene, Xinjie Zhao, Juergen Machann, Andreas L. L. Birkenfeld, Martin Heni, Andreas Peter, Andreas Niess, Anja Moller, Rainer Lehmann, Guowang Xu, Cora Weigert
Summary: Physical exercise is a powerful preventative measure for cardiometabolic diseases. The individual response to lifestyle interventions varies and cannot currently be predicted. Recent research has shown that Lac-Phe produced during exercise could contribute to weight loss and potentially explain differences in the effectiveness of exercise interventions in humans.
Article
Biochemistry & Molecular Biology
Manuela A. Oestereicher, Janine M. Wotton, Shinya Ayabe, Ghina Bou About, Tsz Kwan Cheng, Jae-Hoon Choi, Dave Clary, Emily M. Dew, Lahcen Elfertak, Alain Guimond, Hamed Haseli Mashhadi, Jason D. Heaney, Lois Kelsey, Piia Keskivali-Bond, Federico Lopez Gomez, Susan Marschall, Michael McFarland, Hamid Meziane, Violeta Munoz Fuentes, Ki-Hoan Nam, Zuzana Nichtova, Dale Pimm, Lynette Bower, Jan Prochazka, Jan Rozman, Luis Santos, Michelle Stewart, Nobuhiko Tanaka, Christopher S. Ward, Amelia M. E. Willett, Robert Wilson, Robert E. Braun, Mary E. Dickinson, Ann M. Flenniken, Yann Herault, K. C. Kent Lloyd, Ann-Marie Mallon, Colin McKerlie, Stephen A. Murray, Lauryl M. J. Nutter, Radislav Sedlacek, Je Kyung Seong, Tania Sorg, Masaru Tamura, Sara Wells, Elida Schneltzer, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Jacqueline K. White, Nadine Spielmann
Summary: This study provides the first reference ranges for electrocardiography in laboratory mice, which are important for diagnostic decision-making and pre-clinical scientific research.
Review
Biochemistry & Molecular Biology
Jiri Lindovsky, Zuzana Nichtova, Nathalia R. V. Dragano, David Pajuelo Reguera, Jan Prochazka, Helmut Fuchs, Susan Marschall, Valerie Gailus-Durner, Radislav Sedlacek, Martin Hrabe de Angelis, Jan Rozman, Nadine Spielmann
Summary: Cardiovascular diseases have a high mortality rate globally and pose a significant burden on health care systems. The International Mouse Phenotyping Consortium (IMPC) utilizes mouse models to study cardiovascular diseases and aims to target each protein-coding gene to examine multiple organ systems. This review discusses the recent advances of the IMPC in cardiac research, focusing on the diagnostic requirements for high-throughput electrocardiography and transthoracic echocardiography in mice. Additionally, it explores the relationship between metabolism and the heart, highlighting the phenotypes that emerge in knockout mice for certain genes and identifying novel loss-of-function genes affecting both metabolism and the cardiovascular system.
Article
Biochemistry & Molecular Biology
Christina Bukas, Isabella Galter, Patricia da Silva-Buttkus, Helmut Fuchs, Holger Maier, Valerie Gailus-Durner, Christian L. Mueller, Martin Hrabe de Angelis, Marie Piraud, Nadine Spielmann
Summary: Echo2Pheno is an automatic statistical learning workflow specifically designed for analyzing and interpreting high-throughput non-anesthetized transthoracic murine echocardiographic images. It accurately confirms known cardiovascular genotype-phenotype relationships and discovers novel genes causing altered cardiovascular phenotypes. This provides an important step toward automatic end-to-end learning for linking echocardiographic readouts to cardiovascular phenotypes in conscious mice.
Article
Biochemistry & Molecular Biology
Patricia da Silva-Buttkus, Nadine Spielmann, Tanja Klein-Rodewald, Christine Schuett, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Lillian Garrett, Raffaele Gerlini, Markus Kraiger, Stefanie Leuchtenberger, Manuela A. Oestereicher, Birgit Rathkolb, Adrian Sanz-Moreno, Claudia Stoeger, Sabine M. Hoelter, Claudia Seisenberger, Susan Marschall, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis
Summary: Rare diseases pose challenges in medicine due to their diverse clinical manifestations and low prevalence. The lack of specific treatments for the majority of rare diseases highlights the need for research. Genome sequencing technology allows for the identification of potential disease-causing genes, but further confirmation is required. Mouse knockout models are crucial for studying the genetics of rare diseases and the German Mouse Clinic is a pioneer in this field. Collaboration between research institutions, clinicians, and patient groups is necessary to advance the understanding and treatment of rare diseases.
Article
Cell Biology
Daniel Garger, Martin Meinel, Tamina Dietl, Christina Hillig, Natalie Garzorz-Stark, Kilian Eyerich, Martin Hrabe de Angelis, Stefanie Eyerich, Michael P. P. Menden
Summary: Through studying the association between various phenotypic traits and lifespan, it was found that somatic mutation and resting heart rate are negatively correlated with lifespan, while other traits show strong associations. Resting heart rate enhances the prediction of lifespan, indicating its direct influence or representation of lower-level mechanisms associated with lifespan.
Meeting Abstract
Immunology
Henning Jacobsen, Kerstin Walendy-Gnirss, Nilgun Tekin-Bubenheim, Nancy Mounogou Kouassi, Isabel Ben-Batalla, Nikolaus Berenbrok, Martin Wolff, Vinicius Pinho dos Reis, Martin Zickler, Lucas Scholl, Annette Gries, Hanna Jania, Arne Duesedau, Gundula Pilnitz-Stolze, Aicha Jeridi, Ali O. Yildirim, Helmut Fuchs, Valerie Gailus-Durner, Claudia Stoeger, Martin Hrabe de Angelis, Tatjana Manuylova, Karin Klingel, Fiona J. Culley, Jochen Behrends, Sonja Loges, Bianca Schneider, Susanne Krauss-Etschmann, Peter Openshaw, Guelsah Gabriel
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asrar Ali Khan, Gema Valera Vazquez, Montse Gustems, Rafaele Matteoni, Fei Song, Philipp Gormanns, Sabine Fessele, Michael Raess, Martin de Angelis, INFRAFRONTIER Consortium
Summary: INFRAFRONTIER has become a prominent research infrastructure in Europe for mouse model generation, phenotyping, archiving, and distribution. With a network of 22 partners from 15 countries, INFRAFRONTIER continuously expands its resources and services for the research community. By combining European rodent model expertise, INFRAFRONTIER aims to enhance accessibility of cutting-edge disease modelling technologies in Europe. The article provides an overview of INFRAFRONTIER's latest developments, its widely utilized services, resources, and technical advancements, including its database, Curated Disease Models, Cancer and Rare Disease resources, and state-of-the-art services.
Article
Endocrinology & Metabolism
Rui Fu, Kathryn Walters, Michael L. Kaufman, Katrina Koc, Amber Baldwin, Michael R. Clay, Kaitlin J. Basham, Katja Kiseljak-Vassiliades, Lauren Fishbein, Neelanjan Mukherjee
Summary: This study investigated the cell differentiation model in the human adrenal cortex and characterized aldosterone-producing micronodules (APMs) using spatially resolved in situ transcriptomics. The findings supported the centripetal differentiation model in humans and identified heterogeneity between APMs.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Leona Kovac, Thomas Goj, Meriem Ouni, Martin Irmler, Markus Jaehnert, Johannes Beckers, Martin Hrabe De Angelis, Andreas Peter, Anja Moller, Andreas L. Birkenfeld, Cora Weigert, Annette Schuermann
Summary: Exercise training can improve glucose tolerance in obese individuals, but some may not respond positively. This study analyzed gene expression and DNA methylation in skeletal muscle of low and high responders to endurance training, identifying differences in gene expression and potential novel markers for intervention success.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Endocrinology & Metabolism
R. Jumpertz von Schwartzenberg, K. Bodis, J. Martin, M. Schon, M. Hrabe de Angelis, N. Perakakis, S. Kabisch, A. Pfeiffer, M. Blueher, J. Szendroedi, N. Stefan, R. Wagner, A. L. Birkenfeld, M. Roden, A. Fritsche