Review
Biochemistry & Molecular Biology
Amir Mohammad Malvandi, Seyed Hamidreza Rastegar-Moghaddam, Saeede Ebrahimzadeh-Bideskan, Giovanni Lombardi, Alireza Ebrahimzadeh-Bideskan, Abbas Mohammadipour
Summary: Spinal cord injury (SCI) is a devastating neurological condition that causes physical disability, psychological stress, and financial burden. miR-21, which is highly expressed in SCI, has been found to have protective effects against SCI by inhibiting inflammation, improving blood-spinal cord barrier function, regulating angiogenesis, and controlling glial scar formation. This review provides a new therapeutic perspective for miR-21 in SCI.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Yulin Zhao, Aimin Li
Summary: Emerging studies have shown that miR-19b-3p is downregulated in IVDD patients and can suppress HNPC apoptosis and promote proliferation by regulating the PTEN/PI3K/Akt/mTOR pathway.
Article
Biochemistry & Molecular Biology
Reem Sabry, Makenna Williams, Nicholas Werry, Jonathan LaMarre, Laura A. Favetta
Summary: This study investigates the regulation of miR-21 in bovine granulosa cells and its potential mechanisms. The research shows that miR-21 has anti-apoptotic effects and explains its impact on specific apoptotic targets. Additionally, the study confirms the influence of BPA on miR-21 expression and explores the temporal effects of BPA on miR-21 regulation. Furthermore, the research reveals that BPA induces upregulation of miR-21 expression by modulating upstream regulators. Overall, this study enhances our understanding of the function of miR-21 in granulosa cells and the mechanisms underlying BPA-induced reproductive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Da Liu, Bo Wang, Min Qiu, Ying Huang
Summary: miR-19b-3p is involved in bone loss after SCI by inhibiting osteogenesis through the PTEN/Akt/mTOR signaling pathway, regulating autophagy to affect the osteogenic differentiation of BMSCs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Yuyong Chen, Zhenming Tian, Lei He, Can Liu, Nangxiang Wang, Limin Rong, Bin Liu
Summary: Exosomes derived from miR-26a-modified MSC can promote axonal regeneration, improve neurogenesis, and attenuate glial scarring through the PTEN/AKT/mTOR signaling cascades in spinal cord injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Tianyu Sun, Liying Duan, Jiaju Li, Hongyu Guo, Mingyue Xiong
Summary: The study demonstrated that GP-17 has neuroprotective effects in a mouse model of SCI, improving functional recovery, suppressing neuronal apoptosis and the inflammatory response. These effects were mediated through the regulation of the miR-21/PTEN/AKT/mTOR pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Lu Chen, Xing Li, Jianping Zhu, Binwu Xu, Yurong Gu
Summary: The expression pattern of miRNAs and their associated pathways were studied in contusion spinal cord injury. miR-19a plays a potential role in halting neuronal cell death and its protective effect may be due to its regulatory effect on pro-apoptotic genes.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yunxiang Chen, Zijian Wei, Jun Liu, Hao Xie, Binbin Wang, Ji Wu, Zezhang Zhu, Yuejun Fan
Summary: The study demonstrated that ZFAS1 promotes SCI progression by binding with miR-1953 and regulating the PTEN/PI3K/AKT pathway, which may offer a novel insight for SCI treatment.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Clinical Neurology
Shuhui Guo, Jianmin Chen, Ye Yang, Xiaolu Li, Yun Tang, Yuchang Gui, Jianquan Chen, Jianwen Xu
Summary: This study elucidated the role of miR-106b-5p in electroacupuncture (EA) treatment of spinal cord injuries (SCIs). The results showed that EA downregulated miR-106b-5p to promote autophagy and inhibit apoptosis, thereby alleviating SCI-mediated neuronal injuries.
Article
Oncology
Juncheng Wang, Yin Zhao, Yifan Tang, Fengning Li, Xiongsheng Chen
Summary: The study found that lncRNA-MEG regulates neuronal cell apoptosis in SCI by targeting miR-21-5p, thereby affecting the expression of PDCD4.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Fengshou Chen, Jie Han, Xiaoqian Li, Zaili Zhang, Dan Wang
Summary: Overexpression of miR-9 improves neurological outcomes after spinal cord ischemia-reperfusion injury and may inhibit blood-spinal cord barrier disruption, neuroinflammation, and apoptosis through MAP2K3- or Notch2-mediated signaling pathways.
Article
Neurosciences
Hongxiang Hong, Guanhua Xu, JiaJia Chen, Jinlong Zhang, Chu Chen, Chunshuai Wu, Jiawei Jiang, Zhiming Cui
Summary: This study found that LncRNA RMRP plays a regulatory role in spinal cord injury through the regulation of the miR-766-5p/FAM83A axis, and its overexpression can alleviate the condition of SCI, increase cell viability and proliferation, and inhibit apoptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Guang Kong, Wu Xiong, Cong Li, Chenyu Xiao, Siming Wang, Wenbo Li, Xiangjun Chen, Juan Wang, Sheng Chen, Yongjie Zhang, Jun Gu, Jin Fan, Zhengshuai Jin
Summary: This study explores the influence of Treg cells on the recovery of BSCB after spinal cord injury (SCI) and its underlying mechanism. The findings suggest that Treg cell-derived exosomes can affect BSCB integrity and motor function by regulating the expression of IRAK1. This provides novel insights for functional repair and inflammation limitation after SCI.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Neurosciences
Zhelun Yang, Zeyan Liang, Jian Rao, Haishu Xie, Maochao Zhou, Xiongjie Xu, Yike Lin, Fabin Lin, Chunhua Wang, Chunmei Chen
Summary: H-EV promotes astrocyte transformation from A1 phenotype to A2 phenotype by delivering miR-21, providing new targets and ideas for the treatment of SCI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Liming He, Qiang Chang, Yannan Zhang, Xiaoming Guan, Zhuo Ma, Xu Chen, Wenbo Liu, Yakun Li, Haoyu Feng
Summary: Central nervous injury and regeneration repair are challenging in neuroscience. The study explores the effect of miR-155-5p on astrocyte activation and glial scar formation. The results demonstrate that miR-155-5p promotes astrocyte proliferation and inhibits cell apoptosis, resulting in increased scar formation. These findings have significant implications for the development of miRNA-based therapeutics for central nervous injury.
NEUROCHEMICAL RESEARCH
(2023)