Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Oncology
Patrick T. Magahis, Steven B. Maron, Darren Cowzer, Stephanie King, Mark Schattner, Yelena Janjigian, David Faleck, Monika Laszkowska
Summary: This study found an association between H. pylori infection and inferior survival in patients with gastric cancer treated with immune checkpoint inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
John D. Murphy, Andrew F. Olshan, Feng-Chang Lin, Melissa A. Troester, Hazel B. Nichols, Julia Butt, You-Lin Qiao, Christian C. Abnet, Manami Inoue, Shoichiro Tsugane, Meira Epplein
Summary: This study developed a predictive model for noncardia gastric adenocarcinoma risk using serum data on pepsinogen, antibody response to 13 H. pylori antigens, demographic, and lifestyle factors. The model showed higher accuracy and sensitivity compared to the ABC Method, and could assist in targeting screening resources to individuals at high risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Yang Zhang, Duo Chen, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wei-Cheng You, Kai-Feng Pan
Summary: This study identified potential H.pylori-associated methylation biomarkers in blood leukocyte and gastric mucosa, showing that GNAS and MTERFI methylation levels may be affected by H.pylori infection. GNAS may be involved in the advanced stage of gastric cancer development, with a negative relationship found between GNAS methylation and mRNA expression as well as worse survival outcomes in GC cases with higher GNAS expression levels.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ali Nabavi-Rad, Abbas Yadegar, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Daniel J. Klionsky, Yoshio Yamaoka
Summary: Chronic infection with Helicobacter pylori is the primary risk factor for the development of gastric cancer, but the role of autophagy in this process is complex and context-dependent. Recent research has uncovered new frontiers of interaction between H. pylori virulence and autophagy. The autophagy signaling networks have critical influences on the structure of gut microbiota and the metabolome.
TRENDS IN MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Oncology
Chih-Hao Chang, Arthur Chun-Chieh Shih, Ya-Hsuan Chang, Hsuan-Yu Chen, Ying-Ting Chao, Yi-Chiung Hsu
Summary: The study found that high expression of PD1 and PDL1 is associated with favorable outcomes in early-stage lung cancer but adverse outcomes in late-stage lung cancer. The expression levels of PD1 and PDL1 can serve as potential prognostic factors for predicting patient outcomes in lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Microbiology
Ling Zhang, Ming Zhao, Xiangsheng Fu
Summary: Helicobacter pylori (H. pylori) infection is a common cause of gastric disease, but the increase in antibiotic resistance has made it challenging to eradicate. The stomach has a unique microecology that can have positive, negative, or neutral effects on microbial fitness and function. This article reviews the imbalance of gastric microecology and its relationship with H. pylori, as well as potential methods for modulating gastric microecology to facilitate H. pylori eradication, such as probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Jiao Li, Shan Tian, Yingyun Guo, Weiguo Dong
Summary: AMAP1 mRNA and protein levels were found to be upregulated in gastric cancer specimens compared to normal tissues. High AMAP1 mRNA abundance was associated with poor overall survival and reduced progression-free survival in patients with gastric cancer. AMAP1 was negatively correlated with miR-192-3p and acted as a novel oncogene in gastric cancer, serving as a potential diagnostic and prognostic marker.
FRONTIERS IN GENETICS
(2021)
Review
Gastroenterology & Hepatology
Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Kadima Nayara Teixeira, Fabricio Freire de Melo
Summary: Gastric mucosa-associated lymphoid tissue lymphoma (GML) is a low-grade B-cell neoplasia commonly associated with chronic gastritis induced by Helicobacter pylori (H. pylori) infection. However, a subset of GML patients are H. pylori-negative. Despite previous beliefs, it has been found that a considerable proportion of H. pylori-negative GML patients show complete remission after bacterial eradication therapy. The mechanisms underlying this treatment responsiveness are not fully understood, and further research is needed to establish the causal relationship between non-H. pylori gastric helicobacters (NHPHs) and GML.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Dongsheng Liu, Jinyun Wang, Yong Xie
Summary: Refractory Helicobacter pylori infection leads to significant alterations in gastric microbiota, inhibiting the growth of beneficial Lactobacillus. Patients with refractory H. pylori infection may be more prone to developing gastric cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)