Article
Chemistry, Analytical
Tana Sebechlebska, Eva Vaneckova, Marta Katarzyna Choinska-Mlynarczyk, Tomas Navratil, Lukasz Poltorak, Andrea Bonini, Federico Vivaldi, Viliam Kolivoska
Summary: Fused deposition modeling 3D printing using electrically conductive filaments is an attractive tool for manufacturing sensing devices. This study explores the capabilities of 3D printed electrodes to measure electric properties of materials. The authors demonstrate the functionality of a bimaterial FDM-3DP platform for sensing conductivity and permittivity of liquids by impedance measurements. Additionally, they propose an original idea of using impedance measurements to investigate dimensions of 3D printed channels as base structures of microfluidic devices, complemented by optical microscopic analysis.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Adelina-Gabriela Niculescu, Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu
Summary: Microfluidics is an emerging field that combines principles from various disciplines to fabricate miniaturized chips with channels and chambers. These chips, made using diverse methods, can be utilized in nanoparticle preparation, cell analysis, and diagnosis, among other biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Materials Science, Multidisciplinary
Shambhulinga Aralekallu, Rajamouli Boddula, Vijay Singh
Summary: The advent of glass-based microfluidic devices has revolutionized microfluidic technology due to their advantageous properties compared to other materials. This review discusses the suitability and benefits of glass materials for microfluidic device fabrication compared to inorganic, organic polymeric, and paper materials. The review also highlights the performance enhancement achieved by hybrid fabrication of glass with advanced polymers. Additionally, it considers recent advances in glass-based microfluidics in various sensing and biomedical applications and concludes by summarizing future challenges and developments.
MATERIALS & DESIGN
(2023)
Article
Polymer Science
Abdulrahman Agha, Fadi Dawaymeh, Nahla Alamoodi, Eiyad Abu-Nada, Anas Alazzam
Summary: COC is a promising material for microfluidic applications due to its unique properties. A new fabrication process combining fabrication and bonding processes in a single step was implemented, utilizing COC's swelling behavior and chemical compatibility. The effect of immersion time on microchannel height was investigated, achieving a maximum height of 50 ± 3μm. Bonding quality was evaluated through leakage and tensile tests. Three diverse microfluidic applications were successfully executed, demonstrating the effectiveness of the process.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Analytical
Pyeong An Lee, Ui Seok Lee, Dae Bo Sim, Bo Hyun Kim
Summary: In this paper, polycrystalline diamond tools were fabricated and used for the microgrinding process of fused silica. The effects of high feed rate and depth of cut on surface roughness and edge chipping were studied to improve productivity. Additionally, a toolpath for microchannels and a microfluidic chip array were successfully fabricated using this method.
Article
Engineering, Biomedical
Qiangqiang Tang, Xiaoyu Li, Chen Lai, Lei Li, Hongkai Wu, Yingjun Wang, Xuetao Shi
Summary: In this study, a microfluidic chip using HA as a component was developed to create a highly bionic bone environment, which was found to be more conducive to cell proliferation and osteogenic differentiation compared to PDMS. The chip successfully generated a concentration gradient of model drug and determined the drug's IC50, showing great potential in high-throughput bone-related drug screening and research.
BIOACTIVE MATERIALS
(2021)
Article
Biochemical Research Methods
Gihyun Lee, Soo Jee Kim, Je-Kyun Park
Summary: The tumor microenvironment (TME) is crucial for the nourishment of tumors and delivery of chemotherapy drugs, but existing bioprinting and microfluidic technologies have not fully utilized the potential benefits of precise spatial control and adjustment of culture environments. This study introduces a novel integrative technology that combines a self-organized TME array bioprinted on a microfluidic chip with a vascular endothelial barrier surrounding breast cancer spheroids.
Article
Biochemical Research Methods
Gihyun Lee, Soo Jee Kim, Je-Kyun Park
Summary: This study describes a novel integrative technology that combines bioprinting and microfluidics to create a self-organized tumor microenvironment (TME) array on a microfluidic chip. The TME array consists of a vascular endothelial barrier surrounding breast cancer spheroids. This technology offers potential benefits such as precise spatial control, multiple TMEs per microfluidic device, and adjustable culture environments for better biological similarity.
Article
Polymer Science
Junyeol Rhyou, Jaeseung Youn, Seongsu Eom, Dong Sung Kim
Summary: This study introduces a new method for fabricating a nanofiber membrane-integrated polydimethylsiloxane (NFM-PDMS) microfluidic chip by using a silver nanowires-embedded uncured PDMS adhesive layer to improve the efficiency and sealing performance of traditional electrospinning. The chip demonstrates good growth performance when culturing the human keratinocyte cell line HaCaT cells.
Review
Biochemistry & Molecular Biology
Uyen M. N. Cao, Yuli Zhang, Julie Chen, Darren Sayson, Sangeeth Pillai, Simon D. D. Tran
Summary: Organ-on-A-chip (OoAC) devices are miniaturized in vitro constructs that aim to replicate the in vivo physiology of an organ. Different biomaterials and fabrication strategies are used to create these devices, with certain biomaterials like PDMS being preferred for their ease of fabrication. Advances in 3D printing and bioprinting techniques have allowed for the development of more complex microfluidic OoAC devices. This review evaluates the materials used for fabricating microfluidic OoAC devices and discusses the combination of additive manufacturing techniques for microfabrication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Yongan Ren, Ke Ge, Danyang Sun, Zichen Hong, Changku Jia, Huan Hu, Fangwei Shao, Bo Yao
Summary: A strategy and technology were proposed to assess the lipid amount and membrane protein expression of extracellular vesicles, along with the development of a microfluidic platform for effective EVs enrichment and detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Amin Dehghan, Ali Gholizadeh, Mahdi Navidbakhsh, Hossein Sadeghi, Esmail Pishbin
Summary: Micromixers are essential microfluidic modules for fabricating integrated lab-on-chip devices for point-of-care applications. In this study, a magnetic stirrer on a rotating micro-structured disk is presented to mix liquids of a wide range of viscosities in low rotational velocities. The on-disk magnetic stirrer can be implemented in integrated micmfluidic platforms without affecting other modules, and it is a convenient choice for the cell lysis process due to high mixing indexes and considerable viscous stresses.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Tanoy Sarkar, Trieu Nguyen, Sakib M. Moinuddin, Kurt R. Stenmark, Eva S. Nozik, Dipongkor Saha, Fakhrul Ahsan
Summary: This article describes the fabrication and development of a pulmonary arterial hypertension (PAH) chip model using microfluidic technology. The model is capable of mimicking major pathological features of PAH and has the potential to advance our understanding of its pathophysiology, sexual dimorphism, and personalized therapy.
Article
Engineering, Chemical
Ali Kalantarifard, Elnaz Alizadeh-Haghighi, Caglar Elbuken
Summary: This study demonstrates a universal method for high monodispersity droplet generation, which is immune to external fluctuations originating from the imperfection of the flow source. The method is applicable to other common microfluidic devices and flow sources.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Yue Wu, Yuwen Zhao, Yuyuan Zhou, Khayrul Islam, Yaling Liu
Summary: Currently, the most commonly used in vitro tumor model for drug testing is the two-dimensional cell monolayer, but it fails to replicate the natural tumor microenvironment. This study presents an integrated engineering system to generate vessel-supported tumor models for preclinical drug screening. It provides a more realistic tumor microenvironment and has the potential to improve the efficiency of drug discovery.
ACS APPLIED MATERIALS & INTERFACES
(2023)
