Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 108, Issue 4, Pages 1559-1567Publisher
WILEY
DOI: 10.1002/jbm.b.34503
Keywords
biomaterial; electrospinning; membrane; microwave-assisted hydrothermal synthesis; niobium pentoxide
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [001]
- Erasmus BE Mundus
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul [PqG 2017 17/2551-0001157-0]
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Tissue engineering aims to regenerate and restore damaged human organs and tissues using scaffolds that can mimic the native tissues. The requirement for modern and efficient biomaterials that are capable of accelerating the healing process has been considerably increased. In this work, a novel electrospun poly(lactic acid) (PLA) nanoporous membrane incorporated with niobium pentoxide nanoparticles (Nb2O5) for biomaterial applications was developed. Nb2O5 nanoparticles were obtained by microwave-assisted hydrothermal synthesis, and different concentrations (0, 1, 3, and 5% wt/wt) were tested. Chemical, morphological, mechanical, and biological properties of membranes were evaluated. Cell viability results demonstrated that the membranes presented nontoxic effects. The incorporation of Nb2O5 improved cell proliferation without impairing the wettability, porosity, and mechanical properties of membranes. Membranes containing Nb2O5 nanoparticles presented biocompatible properties with suitable porosity, which facilitated cell attachment and proliferation while allowing diffusion of oxygen and nutrients. This study has demonstrated that Nb2O5 nanoparticle-loaded electrospun PLA nanoporous membranes are potential candidates for drug delivery and wound dressing applications.
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