Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome

(2019) Samuel J. Pellock et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

(2019) Kristen A. Biernat et al.   Scientific Reports

Selecting a Single Stereocenter: The Molecular Nuances That Differentiate β-Hexuronidases in the Human Gut Microbiome

(2019) Samuel J. Pellock et al.   BIOCHEMISTRY

Role of Bile Acids in Metabolic Control

(2018) Antonio Molinaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

(2018) Samuel J. Pellock et al.   ACS Central Science

Active Site Flexibility Revealed in Crystal Structures of Parabacteroides merdae β-Glucuronidase from the Human Gut Microbiome

(2018) Michael S. Little et al.   PROTEIN SCIENCE

Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis

(2018) Samuel J. Pellock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen–gut microbiome axis: Physiological and clinical implications

(2017) James M. Baker et al.   MATURITAS

Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae

(2017) Michael S. Little et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Atlas of β-Glucuronidases in the Human Intestinal Microbiome

(2017) Rebecca M. Pollet et al.   STRUCTURE

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Estrobolome Disparities May Lead To Developing Bimoarkers That Could Mitigate Cancer Risk

(2016)   JNCI-Journal of the National Cancer Institute

Estrogen and Microbiota Crosstalk: Should We Pay Attention?

(2016) Karen L. Chen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Estrobolome Disparities May Lead To Developing Bimoarkers That Could Mitigate Cancer Risk

(2016)   JNCI-Journal of the National Cancer Institute

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Estrogen metabolism and breast cancer

(2015) Hamed Samavat et al.   CANCER LETTERS

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

(2015) Bret D. Wallace et al.   CHEMISTRY & BIOLOGY

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

(2013) Kyle S. Saitta et al.   XENOBIOTICA

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

(2012) Jean Guy LeBlanc et al.   CURRENT OPINION IN BIOTECHNOLOGY

Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies

(2012) Urs A. Boelsterli et al.   TOXICOLOGICAL SCIENCES

Microbiome and Malignancy

(2011) Claudia S. Plottel et al.   Cell Host & Microbe

NSAID Acyl Glucuronides and Enteropathy

(2011) Urs A. Boelsterli et al.   CURRENT DRUG METABOLISM

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES