The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies

Surrogate CD16-expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies

(2017) Shalom A. Gurjar et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments

(2017) Elena Krayukhina et al.   mAbs

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

(2016) Suneale Banerji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma and Synovial Fluid TrxR Levels are Correlated With Disease Risk and Severity in Patients With Rheumatoid Arthritis

(2016) Zhijun Xie et al.   MEDICINE

Effect of trastuzumab interchain disulfide bond cleavage on Fcγ receptor binding and antibody-dependent tumour cell phagocytosis

(2015) Mami Suzuki et al.   JOURNAL OF BIOCHEMISTRY

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

CD44 Binding to Hyaluronic Acid Is Redox Regulated by a Labile Disulfide Bond in the Hyaluronic Acid Binding Site

(2015) Helena Kellett-Clarke et al.   PLoS One

Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

(2014) Aming Zhang et al.   ANALYTICAL CHEMISTRY

Cleavage of the interchain disulfide bonds in rituximab increases its affinity for FcγRIIIA

(2013) Mami Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View

(2013) Shi Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Treating Tumor Necrosis Factor α (TNFα)-associated Diseases with the Therapeutic Antibody Infliximab

(2013) Shuaiyi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal antibody disulfide reduction during manufacturing

(2013) Katariina M. Hutterer et al.   mAbs

Increased Cell Surface Free Thiols Identify Effector CD8+ T Cells Undergoing T Cell Receptor Stimulation

(2013) Samuel Troy Pellom et al.   PLoS One

Expression of Recombinant Antibodies

(2013) André Frenzel et al.   Frontiers in Immunology

Immunoregulation through membrane proteins modified by reducing conditions induced by immune reactions

(2012) Monika Stegmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Label-Free Quantitation of Protein Modifications by Pseudo Selected Reaction Monitoring with Internal Reference Peptides

(2012) Stacy D. Sherrod et al.   JOURNAL OF PROTEOME RESEARCH

Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor

(2012) C. Metcalfe et al.   Open Biology

Rituximab resistance

(2011) Andrew R. Rezvani et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Labile disulfide bonds are common at the leucocyte cell surface

(2011) C. Metcalfe et al.   Open Biology

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing

(2010) Melody Trexler-Schmidt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of disulfide bonds in protein structures

(2010) J. W. H. WONG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

(2010) William Burkitt et al.   PROTEIN SCIENCE

Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor Oxygenation

(2010) Therese Christina Karlenius et al.   Cancers

Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides

(2009) Sophie Curbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

(2009) Teemu T. Junttila et al.   CANCER CELL

Thioredoxins and glutaredoxins as facilitators of protein folding

(2008) Carsten Berndt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants

(2008) Jenny Ceccarelli et al.   INTERNATIONAL JOURNAL OF CANCER