Toll-like receptor 2–dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

(2019) Yunhao Tan et al.   CELL

Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy

(2018) Natalia Bravo-Santano et al.   mSphere

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense

(2017) Philip O. Scumpia et al.   PLoS Pathogens

Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases

(2017) Giampiero Pietrocola et al.   Frontiers in Cellular and Infection Microbiology

Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase

(2016) Yvonne Neumann et al.   Autophagy

Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response

(2016) Casey M. Gries et al.   INFECTION AND IMMUNITY

Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection

(2015) Kate M. O'Keeffe et al.   INFECTION AND IMMUNITY

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

(2014) Kevin S. Bonham et al.   CELL

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

(2014) Jonathan L. Schmid-Burgk et al.   GENOME RESEARCH

A Role for the Adaptor Proteins TRAM and TRIF in Toll-like Receptor 2 Signaling

(2014) Nadra J. Nilsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction

(2014) Julianne Stack et al.   JOURNAL OF IMMUNOLOGY

Induction of Type I Interferon Signaling Determines the Relative Pathogenicity of Staphylococcus aureus Strains

(2014) Dane Parker et al.   PLoS Pathogens

Thirty-day mortality in UK patients with community-onset and hospital-acquired meticillin-susceptible Staphylococcus aureus bacteraemia

(2013) M. Melzer et al.   JOURNAL OF HOSPITAL INFECTION

Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin

(2012) Miroslaw Lizak et al.   Cell Host & Microbe

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Failure To Induce IFN-β Production during Staphylococcus aureus Infection Contributes to Pathogenicity

(2012) Amber Kaplan et al.   JOURNAL OF IMMUNOLOGY

Staphylococcus aureus Induces Type I IFN Signaling in Dendritic Cells Via TLR9

(2012) D. Parker et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

(2011) Guy E. Thwaites et al.   NATURE REVIEWS MICROBIOLOGY

Induction of type I interferons by bacteria

(2010) Kathryn M. Monroe et al.   CELLULAR MICROBIOLOGY

Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule

(2010) T. Lysakova-Devine et al.   JOURNAL OF IMMUNOLOGY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Murine Toll-Like Receptor 2 Activation Induces Type I Interferon Responses from Endolysosomal Compartments

(2010) Nicole Dietrich et al.   PLoS One

Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A

(2009) Francis J. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

(2009) E. F. Kenny et al.   JOURNAL OF IMMUNOLOGY

Role ofrsbUand Staphyloxanthin in Phagocytosis and Intracellular Growth ofStaphylococcus aureusin Human Macrophages and Endothelial Cells

(2009) Aurélie C. Olivier et al.   JOURNAL OF INFECTIOUS DISEASES

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

Phagocytosis of Staphylococcus aureus by Macrophages Exerts Cytoprotective Effects Manifested by the Upregulation of Antiapoptotic Factors

(2009) Joanna Koziel et al.   PLoS One

Staphylococcus aureus: new evidence for intracellular persistence

(2009) Christian Garzoni et al.   TRENDS IN MICROBIOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages

(2008) Malgorzata Kubica et al.   PLoS One

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE