Journal
JOURNAL OF ATTENTION DISORDERS
Volume 25, Issue 8, Pages 1068-1079Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1087054719883031
Keywords
adult ADHD; rich-club organization; diffusion tensor imaging
Categories
Funding
- National Natural Science Foundation of China [61873178, 31671150]
- Innovative Team Program in Higher Education of Guangdong, China [2015KCXTD009]
- Major Program of Guangdong, China [2016KZDXM009, 2018B030335001, 2018B030332001]
- Shenzhen Basic Research Scheme [JCYJ20150729104249783]
- Shenzhen Peacock Plan [KQTD2015033016104926]
- Japan Society for the Promotion of Science [18K13368]
- Grants-in-Aid for Scientific Research [18K13368] Funding Source: KAKEN
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The study showed a reduced density of rich-club connections among structural hub nodes in adults with ADHD, along with lower global efficiency compared to TD adults. This reduced connectivity density may lead to altered functional brain dynamics in ADHD patients.
Objective: Whether the abnormal connectome of brain's rich-club structure in adults with attention-deficit hyperactivity disorder (ADHD) remains unclear. Method: The current study used diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) to compare the performance of 42 adults with ADHD and 59 typical development (TD) adults. Results: A reduced density of rich-clubs among structural hub nodes, including the bilateral precuneus, the insula, the caudate nucleus, the left putamen, and the right calcarine, was found in adults with ADHD. Moreover, lower global efficiency was found in adults with ADHD than in TD, which might be caused by a reduced density of rich-club connections in ADHD patients. Conclusion: Given that adults with ADHD have greater coupling strength between structural and functional connectivity than TD adults, connectome abnormalities with a reduced rich-club connectivity density might be accompanied by altered functional brain dynamics in ADHD patients.
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