☆ 4.5 Article

Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus

JOURNAL OF ALZHEIMERS DISEASE (2019)

Journal

JOURNAL OF ALZHEIMERS DISEASE

Volume 71, Issue 4, Pages 1233-1243

Publisher

IOS PRESS

DOI: 10.3233/JAD-190334

Keywords

Alzheimer's disease; computer-assisted diagnosis; normal pressure hydrocephalus

Categories

Neurosciences

Funding

Academy of Finland [263193]
VTR grant of Kuopio University Hospital [V16001]
Finnish Medical Foundation
Sigrid Juselius Foundation
Maire Taponen Foundation
University of Eastern Finland (UEF-Brain)
European Union [601055, 611005]
VPH-DARE@IT project
Academy of Finland (AKA) [263193, 263193] Funding Source: Academy of Finland (AKA)

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Background: Idiopathic normal pressure hydrocephalus (iNPH) patients often develop Alzheimer's disease (AD) related brain pathology. Disease State Index (DSI) is a method to combine data from various sources for differential diagnosis and progression of neurodegenerative disorders. Objective: To apply DSI to predict clinical AD in shunted iNPH-patients in a defined population. Methods: 335 shunted iNPH-patients (median 74 years) were followed until death (n = 185) or 6/2015 (n = 150). DSI model (including symptom profile, onset age of NPH symptoms, atrophy of medial temporal lobe in CT/MRI, cortical brain biopsy finding, and APOE genotype) was applied. Performance of DSI model was evaluated with receiver operating characteristic (ROC) curve analysis. Results: A total of 70 (21%) patients developed clinical AD during median follow-up of 5.3 years. DSI-model predicted clinical AD with moderate effectiveness (AUC= 0.75). Significant factors were cortical biopsy (0.69), clinical symptoms (0.66), and medial temporal lobe atrophy (0.66). Conclusion: We found increased occurrence of clinical AD in previously shunted iNPH patients as compared with general population. DSI supported the prediction of AD. Cortical biopsy during shunt insertion seems indicated for earlier diagnosis of comorbid AD.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Clinical Neurology

Brain linear measurements for differentiating normal pressure hydrocephalus from Alzheimer's disease: an exploratory study

Antonina Luca, Giulia Donzuso, Giovanni Mostile, Roberta Terranova, Calogero Edoardo Cicero, Alessandra Nicoletti, Mario Zappia

Summary: In this study, it was found that Evan's index, POR, and TR can be useful in the differential diagnosis between iNPH and AD. The BLM index, a cumulative index, showed high accuracy at an individual level, making it a reliable tool for differentiation.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Add to Collection

Article Health Care Sciences & Services

Alzheimer's Disease CSF Biomarker Profiles in Idiopathic Normal Pressure Hydrocephalus

Salvatore Mazzeo, Filippo Emiliani, Silvia Bagnoli, Sonia Padiglioni, Lorenzo Maria Del Re, Giulia Giacomucci, Juri Balestrini, Assunta Ingannato, Valentina Moschini, Carmen Morinelli, Giulia Galdo, Cristina Polito, Camilla Ferrari, Gastone Pansini, Alessandro Della Puppa, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi

Summary: Patients with idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's Disease (AD) show similar levels of CSF A beta(42), but the levels of A beta(42)/A beta(40), p-tau, and t-tau are significantly different and can accurately distinguish iNPH from AD. A beta(42)/A beta(40) is the most important variable for differentiation. Positive A beta(42)/A beta(40) in iNPH, especially when associated with positive p-tau, may indicate the presence of coexistent AD pathology.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Add to Collection

Article Multidisciplinary Sciences

Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus

Dejun Yang, Hongwei Yang, Gabrielle Luiselli, Charles Ogagan, Huijun Dai, Lucinda Chiu, Rona S. Carroll, Mark D. Johnson

Summary: Deletions in CWH43 may contribute to adult-onset iNPH by selectively downregulating L1CAM in the ventricular and subventricular zones, leading to changes in N-glycosylation, cell membrane association, cleavage, shedding, and nuclear translocation of L1CAM, ultimately affecting intracellular signaling pathways.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Medicine, Research & Experimental

Deletions in CWH43 cause idiopathic normal pressure hydrocephalus

Hong Wei Yang, Semin Lee, Dejun Yang, Huijun Dai, Yan Zhang, Lei Han, Sijun Zhao, Shuo Zhang, Yan Ma, Marciana F. Johnson, Anna K. Rattray, Tatyana A. Johnson, George Wang, Shaokuan Zheng, Rona S. Carroll, Peter J. Park, Mark D. Johnson

Summary: Idiopathic normal pressure hydrocephalus (iNPH) is a rare neurological disorder characterized by enlarged cerebral ventricles, gait difficulty, and cognitive decline. A study found that heterozygous loss of function deletions in the CWH43 gene may be associated with the disease, providing new insights into its origins.

EMBO MOLECULAR MEDICINE (2021)

Add to Collection

Article Neurosciences

Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

Aleksi Vanninen, Heikki Lukkarinen, Tarja Kokkola, Anne M. Koivisto, Merja Kokki, Tadeusz Musialowicz, Mikko Hiltunen, Henrik Zetterberg, Ville Leinonen, Sanna-Kaisa Herukka, Tuomas Rauramaa

Summary: Alzheimer's disease (AD) is a common cause of dementia, particularly in patients with idiopathic normal pressure hydrocephalus (iNPH). The presence of AD pathology in iNPH is associated with worse outcomes after a shunt procedure. Preoperative diagnosis of AD in iNPH patients is challenging due to reduced cerebrospinal fluid (CSF) AD biomarker concentrations. Our study aimed to determine the effect of iNPH on CSF levels of AD biomarkers and investigate the potential for correction to improve diagnostic value. Results showed significant differences in biomarker levels between groups, and correction for iNPH did not improve diagnostic effectiveness. However, the P-Tau(181)/A beta(1-42) ratio showed some utility in diagnosing AD in iNPH patients.

JOURNAL OF ALZHEIMERS DISEASE (2023)

Add to Collection

Article Neurosciences

Increased Cerebrospinal Fluid Levels of Soluble Triggering Receptor Expressed on Myeloid Cells 2 and Chitinase-3-Like Protein 1 in Idiopathic Normal-Pressure Hydrocephalus

Fuxia Yang, Lu Yang, Xuhao Fang, Yao Deng, Renling Mao, Aijuan Yan, Wenshi Wei

Summary: The study found that CSF sTREM2 levels were higher in iNPH patients, indicating the involvement of neuroinflammation in the pathogenesis of iNPH. Furthermore, the levels of sTREM2 were positively correlated with YKL-40, suggesting the importance of glial cell interactions in iNPH.

JOURNAL OF ALZHEIMERS DISEASE (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Imaging Markers for Normal Pressure Hydrocephalus: An Overview

Efstratios-Stylianos Pyrgelis, Georgios Velonakis, Sokratis. G. G. Papageorgiou, Leonidas Stefanis, Elisabeth Kapaki, Vasilios. C. C. Constantinides

Summary: Idiopathic normal pressure hydrocephalus (iNPH) is a neurological syndrome characterized by cognitive impairment, gait disturbances, and urinary incontinence. Its accurate and early diagnosis is crucial due to its potential reversibility. The main imaging characteristic of iNPH is the dilation of the brain's ventricular system, and imaging parameters are also included in its diagnostic criteria. This literature review highlights the important imaging markers and their role in diagnosing, differentiating, and possibly predicting the prognosis of this potentially reversible neurological syndrome.

BIOMEDICINES (2023)

Add to Collection

Article Neurosciences

The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease

Ossi Nerg, Antti Junkkari, Ilona Hallikainen, Tuomas Rauramaa, Antti Luikku, Mikko Hiltunen, Juha E. Jaaskelainen, Ville Leinonen, Tuomo Hanninen, Anne Koivisto

Summary: This study showed that patients with iNPH performed worse in cognitive tests compared to cognitively healthy individuals, with notable differences in verbal fluency and clock drawing tests when compared to patients with AD. AD patients had more pronounced episodic memory dysfunctions.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Add to Collection

Article Geriatrics & Gerontology

Comparison of cerebrospinal fluid space between probable normal pressure hydrocephalus and Alzheimer's disease

Hongliang Li, Chunyan Liu, Hong Tai, Youping Wei, Taizhong Shen, Qiong Yang, Keyang Zheng, Yan Xing

Summary: INPH can be accurately assessed by measuring intracranial CSF ratio, and the addition of WM ratio and CSF ratio significantly improved the differential diagnostic value of probable INPH from AD compared to CA alone.

FRONTIERS IN AGING NEUROSCIENCE (2023)

Add to Collection

Review Clinical Neurology

A clinical primer for the glymphatic system

Lucas P. Carlstrom, Ahmed Eltanahy, Avital Perry, Alejandro A. Rabinstein, Benjamin D. Elder, Jonathan M. Morris, Fredric B. Meyer, Christopher S. Graffeo, Iben Lundgaard, Terry C. Burns

Summary: The complex and dynamic system of fluid flow through the perivascular and interstitial spaces of the central nervous system (CNS) has implications for various neurological diseases. The glymphatic system, supported by astrocytes, plays a crucial role in directing extracellular fluid and removing waste products in order to optimize neurological function. Dysfunction in this system has been linked to CNS aging, neurodegenerative diseases, CNS injuries, and normal pressure hydrocephalus. Understanding the pathophysiology of glymphatics could lead to new therapeutic approaches.

BRAIN (2022)

Add to Collection

Article Genetics & Heredity

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer's disease

Hunter White, Ryan Webb, Ian McKnight, Kaitlyn Legg, Chan Lee, Peter H. U. Lee, Olivia Smith Spicer, Joon W. Shim

Summary: The symptoms of normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) are similar, leading to misdiagnosis. This study suggests that mRNA biomarkers can be used to differentiate NPH from AD. The TRPV4 gene may play a role in the pathophysiology of NPH and AD.

FRONTIERS IN GENETICS (2022)

Add to Collection

Review Medicine, General & Internal

Reappraisal of Pediatric Normal-Pressure Hydrocephalus

Owen P. Leary, Konstantina A. Svokos, Petra M. Klinge

Summary: This article investigates the clinical phenomenon of pediatric NPH, which has similarities with adult NPH in terms of etiology and pathophysiological mechanisms. By examining clinical evidence and illustrative cases, the article also describes the characteristic manifestations and contemporary treatment options for pediatric NPH.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Review Clinical Neurology

Progression in Neuroimaging of Normal Pressure Hydrocephalus

Rui Yin, Junxian Wen, Junji Wei

Summary: Normal-pressure hydrocephalus is a clinical syndrome that mainly affects the elderly population, characterized by dementia, impaired walking, and malfunction of sphincters. Early diagnosis and surgical intervention are crucial for improving symptoms.

FRONTIERS IN NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Semi-automated assessment of the principal diffusion direction in the corpus callosum: differentiation of idiopathic normal pressure hydrocephalus from neurodegenerative diseases

Maria Eugenia Caligiuri, Andrea Quattrone, Alessandro Mechelli, Domenico La Torre, Aldo Quattrone

Summary: The study proposed a semi-automated approach to assess CC integrity in iNPH based on the spatial distribution of DTI-derived principal diffusion direction orientation (V1). Results showed specific changes of V1 distribution in CC splenium of iNPH compared to AD and PSP, making V1 a powerful biomarker for distinguishing patients with iNPH from patients with AD or PSP.

JOURNAL OF NEUROLOGY (2022)

Add to Collection

Article Clinical Neurology

10-year mortality, causes of death and cardiovascular comorbidities in idiopathic normal pressure hydrocephalus

Sanna A. Eklund, Hanna Israelsson, Mattias Brunstrom, Karin Forsberg, Jan Malm

Summary: This study found that idiopathic normal pressure hydrocephalus (iNPH) patients treated with CSF shunting had a shorter life expectancy. Cardiovascular comorbidities and fatal falls contributed to the increased mortality in iNPH, suggesting the importance of treating iNPH in supplementary ways to reduce mortality.

JOURNAL OF NEUROLOGY (2023)

Add to Collection

Article Clinical Neurology

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Hanna Jokinen, Hanna M. Laakso, Matti Ahlstrom, Anne Arola, Juha Lempiainen, Johanna Pitkanen, Teemu Paajanen, Sietske A. M. Sikkes, Juha Koikkalainen, Jyrki Lotjonen, Antti Korvenoja, Timo Erkinjuntti, Susanna Melkas

Summary: The study revealed strong interrelations between cognitive and motor functions, which were significantly associated with activities of daily living, quality of life, and brain structure in older individuals with cerebral small vessel disease. In this population, there is a complex interplay and synergism between cognitive and motor abilities, leading to functional outcome.

EUROPEAN JOURNAL OF NEUROLOGY (2022)

Add to Collection

Article Clinical Neurology

Occupational complexity and cognition in the FINGER multidomain intervention trial

Anders Rydstrom, Alexander Darin-Mattsson, Ingemar Kareholt, Tiia Ngandu, Jenni Lehtisalo, Alina Solomon, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Tiina Laatikainen, Esko Levalahti, Jaana Lindstrom, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Shireen Sindi, Hilkka Soininen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Francesca Mangialasche

Summary: Higher levels of occupational complexity are associated with better baseline cognition. However, the cognitive benefit of intervention did not vary significantly among participants with different levels of occupational complexity, except for occupational complexity related to data being associated with gains in executive function.

ALZHEIMERS & DEMENTIA (2022)

Add to Collection

Article Clinical Neurology

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Jaana Lindstrom, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto

Summary: Active participation in multidomain lifestyle interventions is associated with better cognitive functioning, especially in overall cognition and executive function. Future interventions should be more intensive and support adherence to lifestyle changes.

ALZHEIMERS & DEMENTIA (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

Jenni Lehtisalo, Minna Rusanen, Alina Solomon, Riitta Antikainen, Tiina Laatikainen, Markku Peltonen, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto, Tiia Ngandu

Summary: A two-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and total cardiovascular disease (CVD) events, particularly among those with a history of CVD.

EUROPEAN HEART JOURNAL (2022)

Add to Collection

Review Clinical Neurology

Dementia Risk Scores and Their Role in the Implementation of Risk Reduction Guidelines

Kaarin J. Anstey, Lidan Zheng, Ruth Peters, Scherazad Kootar, Mariagnese Barbera, Ruth Stephen, Tarun Dua, Neerja Chowdhary, Alina Solomon, Miia Kivipelto

Summary: Dementia prevention is a global health priority. Assessing dementia risk and implementing prevention guidelines require effective tools. Dementia risk scores can help identify high-risk individuals and improve risk perception.

FRONTIERS IN NEUROLOGY (2022)

Add to Collection

Article Clinical Neurology

Multimodal Preventive Trial for Alzheimer's Disease: MIND-ADmini Pilot Trial Study Design and Progress

S. Sindi, C. Thunborg, A. Rosenberg, P. Andersen, S. Andrieu, L. M. Broersen, N. Coley, C. Couderc, C. Z. Duval, G. Faxen-Irving, G. Hagman, M. Hallikainen, K. Hakansson, J. Lehtisalo, N. Levak, F. Mangialasche, J. Pantel, E. Kekkonen, A. Rydstrom, A. Stigsdotter-Neely, A. Wimo, T. Ngandu, H. Soininen, T. Hartmann, A. Solomon, M. Kivipelto

Summary: This study evaluates the feasibility of a modified multimodal lifestyle intervention, either combined with medical food or used independently, for individuals with prodromal Alzheimer's disease (AD). The results of the study demonstrate the effectiveness and acceptance of this intervention method.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2022)

Add to Collection

Article Genetics & Heredity

New insights into the genetic etiology of Alzheimer's disease and related dementias

Celine Bellenguez, Fahri Kucukali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A. Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar De Rojas, Joshua C. Bis, Amber Yaqub, Ivana Prokic, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo Garcia-Gonzalez, Carla Abdelnour, Emilio Alarcon-Martin, Daniel Alcolea, Montserrat Alegret, Ignacio Alvarez, Victoria Alvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antunez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa Beiser, Ana Belen Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Celine Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merce Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossu, Geir Brathen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Burger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Genevieve Chene, Jaeyoon Chung, Michael L. Cuccaro, Roberta Cecchetti, Laura Cervera-Carles, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A. H. R. Claassen, Christopher Clark, Elisa Conti, Anais Corma-Gomez, Emanuele Costantini, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean-Francois Dartigues, Peter Paul de Deyn, Katia de Paiva Lopes, Lot D. De Witte, Stephanie Debette, Jurgen Deckert, Teodoro del Ser, Nicola Denning, Anita Destefano, Martin Dichgans, Janine Diehl-Schmid, Monica Diez-Fairen, Paolo Dionigi Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Duzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Tagliavini Fabrizio, Sune Fallgaard Nielsen, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernandez-Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fliessbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macias, Maria J. Bullido, Ana Frank-Garcia, Lutz Froelich, Brian Fulton-Howard, Daniela Galimberti, Jose Maria Garcia-Alberca, Sebastian Garcia-Madrona, Guillermo Garcia-Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison M. Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio Gonzalez-Perez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grunblatt, Michelle Grunin, Vilmundur Gudnason, Tamar Guetta-Baranes, Annakaisa Haapasalo, Georgios Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton-Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann-Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernandez, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah R. Jun, Yuriko Kastumata, John Kauwe, Patrick G. Kehoe, Lena Kilander, Anne Kinhult Stahlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda B. Kuzma, Carmen Lage, Erika J. Laukka, Lenore Launer, Alessandra Lauria, Chien-Yueh Lee, Jenni Lehtisalo, Ondrej Lerch, Alberto Lleo, William Longstreth, Oscar Lopez, Adolfo Lopez de Munain, Seth Love, Malin Lowemark, Lauren Luckcuck, Kathryn L. Lunetta, Yiyi Ma, Juan Macias, Catherine A. Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquie, Rachel Marshall, Eden R. Martin, Angel Martin Montes, Carmen Martinez Rodriguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menendez-Gonzalez, Pablo Mir, Susanne Moebus, Merel Mol, Laura Molina-Porcel, Laura Montrreal, Laura Morelli, Fermin Moreno, Kevin Morgan, Thomas Mosley, Markus M. Nothen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gael Nicolas, Borge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Caffarra Paolo, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Gina Peloso, Alba Perez-Cordon, Jordi Perez-Tur, Pierre Pericard, Oliver Peters, Yolande A. L. Pijnenburg, Juan A. Pineda, Gerard Pinol-Ripoll, Laudia Pisanu, Thomas Polak, Julius Popp, Danielle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Ines Quintela, Jesper Qvist Thomassen, Alberto Rabano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luis M. Real, Marcel J. T. Reinders, Christiane Reitz, Dolly Reyes-Dumeyer, Perry Ridge, Steffi Riedel-Heller, Peter Riederer, Natalia Roberto, Eloy Rodriguez-Rodriguez, Arvid Rongve, Irene Rosas Allende, Maitee Rosende-Roca, Jose Luis Royo, Elisa Rubino, Dan Rujescu, Maria Eugenia Saez, Paraskevi Sakka, Ingvild Saltvedt, Maria Bernal Sanchez-Arjona, Florentino Sanchez-Garcia, Pascual Sanchez Juan, Raquel Sanchez-Valle, Sigrid B. Sando, Chloe Sarnowski, Claudia L. Satizabal, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott, Geir Selbaek, Davide Seripa, Manuel Serrano, Jin Sha, Alexey A. Shadrin, Olivia Skrobot, Susan Slifer, Gijsje J. L. Snijders, Hilkka Soininen, Vincenzo Solfrizzi, Alina Solomon, Yeunjoo Song, Sandro Sorbi, Oscar Sotolongo-Grau, Gianfranco Spalletta, Annika Spottke, Alessio Squassina, Eystein Stordal, Juan Pablo Tartan, Lluis Tarraga, Niccolo Tesi, Anbupalam Thalamuthu, Tegos Thomas, Giuseppe Tosto, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjaerg-Hansen, Andre Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares, Christine Van Broeckhoven, Jeffery Vance, Badri N. Vardarajan, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John van Swieten, Rik Vandenberghe, Frans Verhey, Jean-Sebastien Vidal, Jonathan Vogelgsang, Martin Vyhnalek, Michael Wagner, David Wallon, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang, Gill Windle, Bob Woods, Mary Yannakoulia, Habil Zare, Yi Zhao, Xiaoling Zhang, Congcong Zhu, Miren Zulaica, Lindsay A. Farrer, Bruce M. Psaty, Mohsen Ghanbari, Towfique Raj, Perminder Sachdev, Karen Mather, Frank Jessen, M. Arfan Ikram, Alexandre de Mendonca, Jakub Hort, Magda Tsolaki, Margaret A. Pericak-Vance, Philippe Amouyel, Julie Williams, Ruth Frikke-Schmidt, Jordi Clarimon, Jean-Francois Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D. Schellenberg, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustin Ruiz, Alfredo Ramirez, Jean-Charles Lambert

Summary: By characterizing the genetic landscape of Alzheimer's disease and related dementias, new loci have been identified and a new genetic risk score associated with the risk of future Alzheimer's disease and dementia has been generated.

NATURE GENETICS (2022)

Add to Collection

Article Clinical Neurology

Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer's disease: a potential early sign of AD

Julen Goikolea, Gorka Gerenu, Makrina Daniilidou, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Juha Rinne, Alina Solomon, Miia Kivipelto, Angel Cedazo-Minguez, Anna Sandebring-Matton, Silvia Maioli

Summary: This study found that serum Trx80 levels are associated with AD disease stage and risk factors such as age and ApoE4 genotype. This suggests that Trx80 could have potential as a serum biomarker for AD.

ALZHEIMERS RESEARCH & THERAPY (2022)

Add to Collection

Article Clinical Neurology

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto

Summary: This study estimated the potential cost-effectiveness of the FINGER program in Finland. The results showed that the FINGER program could save costs and improve quality-adjusted life years, supporting its effectiveness in preventing cognitive impairment and disability.

ALZHEIMERS & DEMENTIA (2023)

Add to Collection

Article Clinical Neurology

β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population

Anna Rosenberg, Ulf Ohlund-Wistbacka, Anette Hall, Alexandre Bonnard, Goran Hagman, Marie Ryden, Charlotta Thunborg, Fleur Wiggenraad, Anna Sandebring-Matton, Alina Solomon, Miia Kivipelto

Summary: This study conducted in a memory clinic in Sweden applied the ATN system to assess patient eligibility for anti-amyloid treatment, showing that the majority of patients did not meet the criteria and emphasizing the need for continued development of disease-modifying treatments with different mechanisms.

NEUROLOGY (2022)

Add to Collection

Article Neurosciences

27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes

Vilma Alanko, Adhara Gaminde-Blasco, Tania Quintela-Lopez, Raul Loera-Valencia, Alina Solomon, Ingemar Bjorkhem, Angel Cedazo-Minguez, Silvia Maioli, Graziella Tabacaru, Maria Latorre-Leal, Carlos Matute, Miia Kivipelto, Elena Alberdi, Anna Sandebring-Matton

Summary: Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative diseases as it can cross the blood-brain barrier. This study found that high levels of 27-OH can impact oligodendrocyte function and contribute to the disconnection of neural networks in neurodegenerative diseases.

GLIA (2023)

Add to Collection

Article Clinical Neurology

Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer's Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial

Suzanne Hendrix, H. Soininen, A. Solomon, P. J. Visser, A. M. J. van Hees, D. S. Counotte, J. Nicodemus-Johnson, S. P. Dickson, K. Blennow, M. Kivipelto, T. Hartmann

Summary: The LipiDiDiet trial evaluated the long term effects of Fortasyn Connect on participants with prodromal AD. The analysis showed that the multinutrient intervention had a significant effect on cognition and global function, as measured by ADCOMS, GST, and BHM. Fortasyn Connect was associated with significantly less clinical decline over 36 months in prodromal AD.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2023)

Add to Collection

Correction Clinical Neurology

Alzheimer's Disease Composite Score: a Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer's Disease (vol 6, pg 232, 2019)

Suzanne B. Hendrix, H. Soininen, A. M. J. van Hees, N. Ellison, P. J. Visser, A. Solomon, A. Attali, K. Blennow, M. Kivipelto, T. Hartmann

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2023)

Add to Collection

Article Clinical Neurology

Cortisol, cognition and Alzheimer's disease biomarkers among memory clinic patients

Jasper Holleman, Sofia Adagunodo, Ingemar Kareholt, Goran Hagman, Malin Aspo, Chinedu T. Udeh-Momoh, Alina Solomon, Miia Kivipelto, Shireen Sindi

Summary: This study investigates the relationship between diurnal cortisol patterns, cognition, and AD biomarkers. The findings suggest associations between cortisol levels and cognitive function, as well as CSF biomarkers related to AD. Further research is needed to understand the complex relationship between cortisol, cognition, and brain pathology.

BMJ NEUROLOGY OPEN (2022)

Add to Collection

Article Geriatrics & Gerontology

Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial

Elisa Neuvonen, Jenni Lehtisalo, Alina Solomon, Riitta Antikainen, Satu Havulinna, Tuomo Hanninen, Tiina Laatikainen, Jaana Lindstrom, Nina Rautio, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu

Summary: This study aimed to investigate the role of psychosocial factors in adherence to lifestyle interventions and lifestyle changes in dementia prevention. The results showed that several psychosocial factors were associated with participation in lifestyle intervention, but fewer contributed to actual lifestyle changes. Although the intervention was beneficial for lifestyle changes independent of psychosocial factors, those most in need of lifestyle improvement were less likely to be active. Tailoring lifestyle-modifying strategies based on the need for psychosocial support may enhance efficacy in future trials.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.