Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhaolin Gao, Min Li, Fei Yao, Xiaobo Xia, Tianqi Duan, Jingzhuo Meng, Yanxia Huang, Ye He, Adonira Saro, Jufang Huang
Summary: The study investigated the effects and underlying mechanisms of valdecoxib on retinal ischemia-reperfusion injury and oxygen-glucose deprivation/recovery injury. The results showed that valdecoxib protected R28 cells by reducing cell apoptosis and exerted a protective effect on retinas by inhibiting retinal ganglion cell apoptosis. In addition, valdecoxib reversed the expression of certain proteins induced by glaucomatous model and the reversal was mediated by the PERK-ATF4-CHOP pathway. These findings suggest that valdecoxib protects against glaucomatous injury by inhibiting ER stress-induced apoptosis via the PERK-ATF4-CHOP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dong-Oh Moon
Summary: This review provides a comprehensive analysis of the multifaceted role of calcium in apoptosis regulation, focusing on its associated signaling pathways and molecular mechanisms. It explores the impact of calcium on apoptosis through its effects on various cellular compartments and highlights its connection to ER stress. Additionally, it discusses the interplay between calcium and proteins such as calpains, calmodulin, and Bcl-2 family members, and its role in regulating caspase activation and pro-apoptotic factor release. Understanding the complex relationship between calcium and apoptosis is crucial for identifying potential treatment options for diseases associated with imbalanced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Qiuya Wu, Duanfang Zhou, Zhengze Shen, Bo Chen, Gang Wang, Lihong Wu, Limei Zhang, Xiaoli Li, Lie Yuan, Yuanli Wu, Na Qu, Weiying Zhou
Summary: VPS34-IN1 is a specific selective inhibitor of Class III Phosphatidylinositol 3-kinase (PI3K) and has been shown to exhibit a significant antitumor effect in leukemia and liver cancer. In this study, the researchers focused on the anticancer effect and potential mechanism of VPS34-IN1 in estrogen receptor positive (ER+ ) breast cancer. The results showed that VPS34-IN1 inhibited the viability of ER+ breast cancer cells by inducing apoptosis through the activation of the PERK/ATF4/CHOP pathway of ER stress. These findings provide new insights and potential treatment strategies for ER+ breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Jingmin Che, Huanhuan Lv, Jiancheng Yang, Bin Zhao, Sibo Zhou, Tongyao Yu, Peng Shang
Summary: In this study, iron overload induced apoptosis in osteoblasts through activating ER stress, resulting in mitochondrial dysfunction. Pretreatment with NAC or TUDC attenuated cell apoptosis and restored protein expression related to iron metabolism.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Turpin, Daed El-Safadi, Gregorie Lebeau, Etienne Frumence, Philippe Despres, Wildriss Viranaicken, Pascale Krejbich-Trotot
Summary: Zika virus manipulates cellular responses to delay apoptosis and optimize virus production; by impairing the expression of CHOP/DDIT3 at a translational level, ZIKV inhibits ER stress-driven apoptosis; ZIKV relies on cellular machinery and the unfolded protein response to complete its viral cycle, posing a threat to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jianbin Zhang, Peng Su, Chong Xue, Diya Wang, Fang Zhao, Xuefeng Shen, Wenjing Luo
Summary: In this study, we found that lead exposure impairs learning and memory by inducing endoplasmic reticulum stress and mitochondrial dysfunction. We also identified that enhanced MFN2 ubiquitination degradation mediated by PINK1 may contribute to mitochondrial dysfunction and endoplasmic reticulum stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mini Jeong, Jong-Il Shin, Jaewook Cho, Yong-Joon Jeon, Jin-Hyun Kim, Jeehee Youn, Kyungho Lee
Summary: In this study, the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from rheumatoid arthritis (RA) patients were investigated. The results showed that DHA treatment induced caspase-8-dependent apoptosis in a dose-dependent manner and reduced the TNF-alpha-mediated induction of MMP-9 and IL-1 beta. DHA also induced ER stress and upregulated the expression of death receptor 5 (DR5) through the activation of CHOP. These findings suggest that DHA can induce apoptosis in RA-FLSs through the upregulation of DR5 via the activation of CHOP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhaohui Cao, Zhuan Wu, Tingting Duan, Cifei Tang, Di Huang, Xiaobo Hu
Summary: This study found that curcumin improves oxidative stress-induced apoptosis in pancreatic beta cells by inhibiting the PERK-CHOP pathway of ER stress. Curcumin acts by activating SIRT1 expression and reducing the expression of CHOP. These findings suggest that curcumin and SIRT1 may serve as a potential therapeutic approach for T1DM.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Multidisciplinary Sciences
Aditi Sharma, Remya Nair, Abhinav Achreja, Anjali Mittal, Pulkit Gupta, Kamakshi Balakrishnan, Claudia L. Edgar, Olamide Animasahun, Bhakti Dwivedi, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Manoj Bhasin, Sagar Lonial, Ajay K. Nooka, Arun P. Wiita, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Summary: This study reveals the link between metabolic state and therapy resistance in multiple myeloma. Suppression of the electron transport chain increases resistance to proteasome inhibitors. Mitochondrial stress-induced resistance can be alleviated by specific drugs.
Article
Multidisciplinary Sciences
Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh, Jothilingam Sivapackiam, Tassia M. Goncalves, George Jarad, Guoyan Zhao, Fumihiko Urano, Vijay Sharma, Ying Maggie Chen
Summary: Albuminuria is not only a symptom but also a cause of glomerular disease, leading to glomerulosclerosis and interstitial fibrosis. The study identifies CHOP and TXNIP as critical molecular linkers in albuminuria-induced kidney injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Yujie Zhong, Lei Wang, Ruyi Jin, Jiayu Liu, Ruilin Luo, Yinghan Zhang, Lin Zhu, Xiaoli Peng
Summary: Diosgenin (DIO) inhibits ROS production by modulating NOX4 and MRC complexes, suppressing mitochondrial and ER stress-induced apoptosis, thereby attenuating diabetic nephropathy (DN).
Article
Biochemistry & Molecular Biology
Jinzhong Jing, Huijin Zeng, Quanjun Shao, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, Xiaoling Chen, Gang Tian, Jingyi Cai, Bo Kang, Lianqiang Che, Hua Zhao
Summary: This study reveals a potential mechanism by which selenium alleviates liver damage and metabolic disorders induced by environmental heat stress in broilers. It promotes the expression of selenoproteins and improves antioxidant capacity, mitigates mitochondrial dysfunction and endoplasmic reticulum stress, and restores normal liver function through regulating AMPK signaling.
Article
Hematology
Brittany C. Lipchick, Adam Utley, Zhannan Han, Sudha Moparthy, Dong Hyun Yun, Anna Bianchi-Smiraglia, David W. Wolff, Emily Fink, Liang Liu, Cristina M. Furdui, Jingyun Lee, Kelvin P. Lee, Mikhail A. Nikiforov
Summary: This study identified the role of lipid metabolism in the resistance of multiple myeloma cells to the proteasome inhibitor bortezomib. Lower levels of fatty acid elongase 6 (ELOVL6) were found in bortezomib-nonresponsive MM cells compared to bortezomib-responsive cells. Restoring ELOVL6 levels resensitized resistant cells by upregulating ceramide species, essential for bortezomib-induced endoplasmic reticulum stress and cell death.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)