Article
Cardiac & Cardiovascular Systems
Bahira Shahim, S. Chris Malaisrie, Isaac George, Vinod H. Thourani, Angelo B. Biviano, Mark Russo, David L. Brown, Vasilis Babaliaros, Robert A. Guyton, Susheel K. Kodali, Tamim M. Nazif, Samir Kapadia, Philippe Pibarot, James M. McCabe, Mathew Williams, Philippe Genereux, Michael Lu, Xiao Yu, Maria Alu, John G. Webb, Michael J. Mack, Martin B. Leon, Ioanna Kosmidou
Summary: The study aimed to assess the occurrence and impact of early and late postoperative atrial fibrillation or flutter in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement. Late postoperative atrial fibrillation or flutter was significantly associated with worse outcomes, while early postoperative atrial fibrillation or flutter was not an independent predictor.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Sandeep Banga, George S. Abela, Frank Saltiel, Tim Fischell, Jagadeesh K. Kalavakunta, Abhinav Sood, George Jolly, Khalid Najib, Haya Al-Ali, Mohammed Qintar, Jason Bazil, Yashbir Singh, Vishal Gupta
Summary: Atrial fibrillation (AF) is a common complication in patients who underwent transcatheter aortic valve implantation, and some of these patients have preexisting AF. The management of these patients is complex, especially after the procedure when there is a sudden change in hemodynamics. Currently, there are no established guidelines for managing AF in patients who underwent transcatheter aortic valve replacement. This review article discusses the use of medications for rate and rhythm control strategies, as well as the role of newer oral anticoagulation medications and left atrial occlusion devices in stroke prevention after the procedure. It also highlights new advances in preventing AF occurrence after transcatheter aortic valve implantation.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jurij M. Kalisnik, Giuseppe Santarpino, Andrea Balbierer, Janez Zibert, Ferdinand A. Vogt, Matthias Fittkau, Theodor Fischlein
Summary: This study aimed to evaluate the thromboembolic risk in patients with atrial fibrillation (AF) and aortic stenosis undergoing aortic valve replacement (AVR) with or without left atrial appendage (LAA) amputation. The results showed that patients who underwent LAA amputation had a lower incidence of ischemic stroke during the follow-up period, without increasing perioperative risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Marisa Avvedimento, Jorge Nuche, Julio I. Farjat-Pasos, Josep Rodes-Cabau
Summary: TAVR has reduced procedural complications, but clinically relevant bleeding still occurs, affecting prognosis. Patients with severe aortic stenosis are at a higher risk for spontaneous bleeding due to age and comorbidities. Individualized bleeding prevention strategies can improve patient care.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyung Ki Jeong, Namsik Yoon, Ju Han Kim, Nuri Lee, Dae Yong Hyun, Min Chul Kim, Ki Hong Lee, Yo Cheon Jeong, In Seok Jeong, Hyun Ju Yoon, Kye Hun Kim, Hyung Wook Park, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho
Summary: AF after AVR is associated with worse outcomes, especially in the SAVR group. TAVR may be a favorable treatment option for high-risk patients with AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Keti Vitanova, Syed Zaid, Gilbert H. L. Tang, Tsuyoshi Kaneko, Vinayak N. Bapat, Thomas Modine, EXPLANT TAVR Investigators
Summary: In this study, the outcomes of AVR and root replacement after TAVR explantation were compared. The results showed no differences in short-term mortality and morbidities between the two groups, although they had different clinical characteristics.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Neel M. Butala, Raj Makkar, Eric A. Secemsky, Dianne Gallup, Guillaume Marquis-Gravel, Andrzej S. Kosinski, Sreekanth Vemulapalli, Javier A. Valle, Steven M. Bradley, Tarun Chakravarty, Robert W. Yeh, David J. Cohen
Summary: This study used data from the TAVR registry to investigate the association between EPD use and in-hospital stroke in TAVR patients. While the primary analysis did not find a significant association, a secondary analysis showed a modestly lower risk of in-hospital stroke with EPD use. Further large-scale randomized controlled trials are needed to determine whether EPDs provide meaningful clinical benefit for TAVR patients.
Article
Cardiac & Cardiovascular Systems
Ahmed Ammar, Ahmed I. Elbatran, Nadeev Wijesuriya, Bunny Saberwal, Syed Y. Ahsan
Summary: Atrial fibrillation is common among patients with severe aortic stenosis, and new onset AF is frequently seen after TAVR. AF has a significant impact on outcomes in TAVR patients, but there is a lack of clear evidence about the optimal management.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Tammy Ryan, Alexander Grindal, Rehman Jinah, Kevin J. Um, Maria E. Vadakken, Avinash Pandey, Iqbal H. Jaffer, Jeff S. Healey, Emilie P. Belley-Cote, William F. McIntyre
Summary: The aim of this study was to investigate the occurrence, outcomes, and predictors of new-onset atrial fibrillation (NOAF) after transcatheter aortic valve replacement (TAVR). The results showed that NOAF after TAVR was associated with longer hospitalization, increased risk of stroke within 30 days, higher 30-day mortality, major or life-threatening bleeding, and permanent pacemaker implantation. Risk factors for developing NOAF after TAVR included higher Society of Thoracic Surgeons score, transapical access, pulmonary hypertension, chronic kidney disease, peripheral vascular disease, and severe mitral regurgitation.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Troels Hojsgaard Jorgensen, Hans Gustav Horsted Thyregod, Nikolaj Ihlemann, Henrik Nissen, Petur Petursson, Bo Juel Kjeldsen, Daniel Andreas Steinbruchel, Peter Skov Olsen, Lars Sondergaard
Summary: In patients with severe aortic valve stenosis at low surgical risk randomized to TAVI or SAVR, there were no significant differences in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure after 8 years of follow-up. However, patients who underwent TAVI had a lower risk of structural valve deterioration compared to those who underwent SAVR.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Troels Hojsgaard Jorgensen, Hans Gustav Horsted Thyregod, Nikolaj Ihlemann, Henrik Nissen, Petur Petursson, Bo Juel Kjeldsen, Daniel Andreas Steinbruchel, Peter Skov Olsen, Lars Sondergaard
Summary: In a study comparing clinical outcomes and valve durability after 8 years of follow-up in patients with symptomatic severe aortic valve stenosis at low surgical risk treated with either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR), no significant differences were found in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure between the two groups.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Adham K. Alkurashi, Sorin V. Pislaru, Jeremy J. Thaden, Jeremy D. Collins, Thomas A. Foley, Kevin L. Greason, Mackram F. Eleid, Gurpreet S. Sandhu, Mohamad A. Alkhouli, Samuel J. Asirvatham, Yong-Mei Cha, Eric E. Williamson, Juan A. Crestanello, Patricia A. Pellikka, Jae K. Oh, Vuyisile T. Nkomo
Summary: Patients with atrial fibrillation (AF) may have underestimated aortic stenosis (AS) severity at the time of referral for transcatheter aortic valve replacement (TAVR). This study compared flow-independent computed tomographic aortic valve calcium scores (AVCS) to mean gradient (MG) in AF versus sinus rhythm (SR) in patients undergoing TAVR. The results showed that AVCS were higher than expected by MG in AF, particularly in men with high-gradient AS (HGAS). This suggests late diagnosis of severe AS in men with AF and HGAS. Further studies are needed to examine the extent of AS severity underestimation by echocardiography in AF.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Review
Cardiac & Cardiovascular Systems
Sascha Macherey, Max Meertens, Victor Mauri, Christian Frerker, Matti Adam, Stephan Baldus, Tobias Schmidt
Summary: This review compares the stroke and mortality rates of valve-in-valve TAVR procedures with native TAVR and provides substantial data for clinical decision-making. The analysis shows no significant differences in short-term and mid-term outcomes between valve-in-valve TAVR and the comparator treatments.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid C. van Nieuwkerk, Raquel B. Santos, Roberto Blanco Mata, Didier Tchetche, Fabio S. de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D'Onofrio, Flavio Ribichini, Jan Baan, Juan Oteo-Dominguez, Nicolas Dumonteil, Alexandre Abizaid, Samantha Sartori, Paola D'Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, Angie Ghattas, Ignacio Amat-Santos, George Dangas, Roxana Mehran, Ronak Delewi
Summary: This study evaluated clinical outcomes in diabetic patients undergoing transcatheter aortic valve implantation (TAVI). The results showed that diabetic patients had comparable mortality rates and other adverse clinical outcomes to non-diabetic patients. This indicates the safety of TAVI treatment in diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Ernesto Ruiz Duque, Ahmed Abdelhamid, Muhammad Khalid, Rupesh Kshetri, Dimitris Chlorogiannis, David Ilias P. Doulamis, Alexandros Briasoulis
Summary: This study retrospectively analyzed the management of patients with cardiogenic shock caused by ACS or ADHF, including the timing of hemodynamic assessment via RHC. The results showed that RHC was performed earlier in patients with more severe cardiac dysfunction, and patients with ACS underwent RHC significantly earlier than those with ADHF.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammed M. Uddin, Tanveer Mir, Alexandros Briasoulis, Emmanuel Akintoye, Oluwole Adegbala, Irfan Shafi, Waqas T. Qureshi, Luis C. Afonso
Summary: This study examines high-output heart failure (HOHF) in the United States and finds that it is associated with non-cardiovascular disorders such as pulmonary disease, obesity, and sepsis. While the in-hospital mortality rates of HOHF and heart failure with reduced ejection fraction (HFrEF) are similar, the 30-day readmission rate for HOHF is significantly lower than that for HFrEF. Timely recognition and awareness of HOHF are important.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin R. Griffin, Mary Vaughan-Sarrazin, Eli Perencevich, Masaaki Yamada, Melissa Swee, Meenakshi Sambharia, Saket Girotra, Heather S. Reisinger, Diana Jalal
Summary: This study developed a mortality prediction model using Veterans Health Administration data to predict the risk of death following acute kidney injury. It found that traditional renal variables contributed less to the risk of death compared to non-kidney factors. This research is significant for the care and management of patients with acute kidney injury.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Athanasios Rempakos, Ilias P. Doulamis, Adamantia Papamichail, Aspasia Tzani, Alexandros Briasoulis
Summary: Cardiac graft failure may lead to the need for repeat heart transplantation. This study compared the outcomes of patients who underwent repeat transplantation with those who underwent initial transplantation. The results showed that the survival rate of repeat transplantation patients remained lower than that of initial transplantation patients, regardless of the implementation of a new donor allocation system. The findings suggest that repeat heart transplantation carries higher mortality risks than initial transplantation.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Paulino A. Alvarez, Alexandros Briasoulis, Aaqib H. Malik
Summary: This study aimed to assess the prevalence, types, trends, and outcomes of infectious disease diagnosis in patients with decompensated heart failure. It found that 24.9% of heart failure patients had an infectious disease diagnosis, which was associated with longer length of stay, higher cost, lower discharge rate, and higher in-hospital mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Eric D. Peterson, Neil Keshvani, Dharam J. Kumbhani, Clyde W. Yancy, Alanna A. Morris, Larry A. Allen, Saket Girotra, Gregg C. Fonarow, Randall C. Starling, Paulino Alvarez, Milind Y. Desai, Peter Cram, Ambarish Pandey
Summary: This study found that using race-specific risk adjustment models can more accurately represent hospital performance for patients of Black and other races in terms of heart failure hospitalization and 30-day risk-standardized readmission rate and risk-standardized mortality rate.
Review
Medicine, General & Internal
Filippos Triposkiadis, Andrew Xanthopoulos, Konstantinos Lampropoulos, Alexandros Briasoulis, Pantelis Sarafidis, John Skoularigis, Harisios Boudoulas
Summary: Multimorbidity, driven by an aging population, is the coexistence of multiple health conditions, including hypertension, heart disease, chronic kidney disease, anemia, etc., in elderly individuals. Regular exercise, salt restriction, statins, and blood pressure control are interventions that can delay arterial stiffness progression and decrease multimorbidity in the elderly.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Adamantia Papamichail, Emmanuel Androulakis, Andrew Xanthopoulos, Alexandros Briasoulis
Summary: This review examines the release of cardiac biomarkers in children after exercise, and finds that it remains unclear how this differs from adults. The study shows that exercise intensity and duration have a significant impact on the elevation of post-exercise biomarkers, but the effects of sport type, age, and sex still need further investigation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ilias P. Doulamis, BoChang Wu, Armaan F. Akbar, Andreas Xanthopoulos, Emmanuel Androulakis, Alexandros Briasoulis
Summary: The changes in the 2018 UNOS allocation system led to an increase in heart transplantations in patients with mechanical circulatory support (MCS). This study aimed to investigate the impact of the new UNOS allocation system on the need for pacemaker implantation and associated complications after heart transplantation. Analysis of the UNOS Registry data showed that 2.9% of heart transplant patients required a pacemaker post-transplantation. There was an era effect and a correlation with pre-transplant ECMO in the need for a pacemaker.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Michael E. Ohl, Kelly Richardson Miell, Brice F. Beck, Bradley Mecham, George Bailey, Michelle Mengeling, Mary Vaughan-Sarrazin
Summary: This study found that most veterans who were hospitalized for COVID-19 chose community hospitals over VHA hospitals, and veterans in community hospitals had higher mortality rates compared to those in VHA hospitals. The VHA needs to understand the reasons behind the mortality difference in order to plan appropriate care for veterans during future COVID-19 surges and the next pandemic.
Letter
Cardiac & Cardiovascular Systems
Issam Motairek, Zhuo Chen, Mohamed H. E. Makhlouf, Salil Deo, Pedro R. V. O. Salerno, Amgad Mentias, Khurram Nasir, Sanjay Rajagopalan, Sadeer G. Al-Kindi
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Letter
Cardiac & Cardiovascular Systems
Abdelrahman I. Abushouk, Ahmed Sayed, Esraa Ghanem, Ahmed Hassanin, Amgad Mentias, Ahmed Bendary, Joanna Ghobrial, Samir Kapadia
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Respiratory System
Spyridon Fortis, Yubo Gao, Kelby Rewerts, Mary Vaughan Sarrazin, Peter J. Kaboli
Summary: The study aimed to estimate the prevalence of chronic hypercapnic respiratory failure (CHRF) and home noninvasive ventilation (NIV) use in individuals with a history of COPD-related hospitalizations. The retrospective analysis of medical records showed that 52.7% of patients had CompHRF, while only 4.3% used home NIV. The rates increased in patients with multiple hospitalizations. Further research is needed to determine CHRF rates and the underutilization of home NIV in larger samples.
CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Rheumatology
Priyanka Iyer, Yubo Gao, Diana Jalal, Saket Girotra, Namrata Singh, Mary Vaughan-Sarrazin
Summary: This study shows that the use of hydroxychloroquine is associated with a lower risk of mortality in older patients with rheumatoid arthritis, but not with the incidence of major adverse cardiovascular events.
CLINICAL RHEUMATOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nikolaos Lionakis, Alexandros Briasoulis, Virginia Zouganeli, Emmanouil Koutoulakis, Dionisios Kalpakos, Andrew Xanthopoulos, John Skoularigis, Christos Kourek
Summary: Coronary artery aneurysms (CAAs) are rare disorders of the coronary arteries, with atherosclerosis and Kawasaki disease being the main causes. Other causes include genetic factors, inflammatory arterial diseases, connective tissue disorders, endothelial damage after cocaine use, iatrogenic complications after interventions, and infections. Diagnostic methods include echocardiography, computed tomography, and magnetic resonance imaging, with coronary angiography remaining the gold standard. There is currently no consensus on the most appropriate therapeutic strategy, but medical therapy and interventions are commonly used depending on the patient's condition and risk factors.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)