Review
Dentistry, Oral Surgery & Medicine
Pongsapak Wongratwanich, Kiichi Shimabukuro, Masaru Konishi, Toshikazu Nagasaki, Masahiko Ohtsuka, Yoshikazu Suei, Takashi Nakamoto, Rinus G. Verdonschot, Tomohiko Kanesaki, Pipop Sutthiprapaporn, Naoya Kakimoto
Summary: Diagnosis of MRONJ is challenging and mainly relies on clinical bone exposure, various imaging modalities can provide more features and information to aid in early detection, but specific imaging features of MRONJ cannot be firmly established at present.
DENTOMAXILLOFACIAL RADIOLOGY
(2021)
Article
Medicine, General & Internal
Petra Rugani, Iva Brcic, Marton Magyar, Uwe Yacine Schwarze, Norbert Jakse, Kurt Ebeleseder
Summary: Autotransplantation of a mature tooth often leads to pulp necrosis. Root canal treatment is recommended to prevent complications. However, conventional dental radiography cannot visualize extraoral root-end resection. Contrast-enhanced magnetic resonance imaging proved to be useful for observing pulp revascularization after autotransplantation, avoiding the need for root canal treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Zineb Assili, Gilles Dolivet, Julia Salleron, Claire Griffaton-Tallandier, Claire Egloff-Juras, Berengere Phulpin
Summary: This study evaluated the incidence of denosumab-related osteonecrosis of the jaw and found that the clinical extent of MRONJ was significantly less than their radiological extent. It is recommended to perform a CBCT during the diagnosis of MRONJ to explore the entire affected dental arch.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ikuya Miyamoto, Ryoichi Tanaka, Shintaro Kogi, Genki Yamaya, Tadashi Kawai, Yu Ohashi, Noriaki Takahashi, Mitsuru Izumisawa, Hiroyuki Yamada
Summary: Radiation therapy plays a significant role in managing head and neck malignancies. Osteoradionecrosis (ORN) can occur as a complication, characterized by bone marrow sclerosis and bone resorption, leading to chronic trismus and pathological fractures. Neurological symptoms may indicate tumor recurrence, but diagnostic imaging is challenging.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Szu-Ting Lin, Alastair K. Foote, Nicholas M. Bolas, Vanessa G. Peter, Rachel Pokora, Hayley Patrick, David R. Sargan, Rachel C. Murray
Summary: This study aimed to compare the diagnostic capabilities of different imaging techniques for identifying fissures in racehorses and to compare them with histopathological findings. The results showed that cone-beam computed tomography had the highest sensitivity, while magnetic resonance imaging had the highest specificity for detecting fissures. Fissures identified on CT were associated with histopathological indications of fatigue bone injuries.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kenneth R. Holmes, R. Davis Holmes, Montgomery Martin, Nicolas Murray
Summary: Radiopaque lesions of the jaw are diverse and require a systematic approach to diagnosis. Categorizing by attenuation pattern and considering other radiologic and clinical features can help narrow down the differential diagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zafeiroula Yfanti, Sotirios Tetradis, Nikolaos G. Nikitakis, Konstantina Eleni Alexiou, Nikolaos Makris, Christos Angelopoulos, Kostas Tsiklakis
Summary: The purpose of this study was to assess the CBCT scans of patients with MRONJ, ORN, OM, and JM, evaluate radiologic findings, identify parameters that distinguish these conditions, and introduce a new modified radiographic index (CRIm) to aid in diagnosis. A total of 335 CBCT scans met the inclusion criteria and were blindly assessed by two observers. The CRIm index evaluates various radiologic features and shows significant differences between different conditions. Extensive lytic changes were the most common finding, particularly in ORN. The new CRIm index appears to improve the objectivity of diagnosing these conditions.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Medicine, General & Internal
Franz Sebastian Schwindling, Sophia Boehm, Christopher Herpel, Dorothea Kronsteiner, Lorenz Vogel, Alexander Juerchott, Sabine Heiland, Martin Bendszus, Peter Rammelsberg, Tim Hilgenfeld
Summary: This study investigated the geometric reproducibility of 3D implant planning based on MRI and CBCT, finding that CBCT showed higher intra- and inter-rater reproducibility compared to MRI. However, further research is needed to enhance planning reproducibility and standardize 3D implant planning for both modalities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Hayo C. van der Helm, Arjan J. A. Dieters, Pieter U. Dijkstra, Wicher J. van der Meer, Anne Marie Kuijpers-Jagtman
Summary: In this study, the validity of the 4D-Jaw Motion module of the ProMax 3D Mid CBCT scanner was tested in vitro. However, the differences between the 4D-JM models and the gold standard exceeded the predefined standards.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kevin R. An, Charles de Mestral, Derrick Y. Tam, Feng Qiu, Maral Ouzounian, Thomas F. Lindsay, Harindra C. Wijeysundera, Jennifer C-Y Chung
Summary: This study found poor adherence to guideline-directed imaging surveillance following ATAAD repair, while long-term mortality and reinterventions rates remained high. Further research is needed to determine if guidelines should be modified.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Ma, Aidi Liu, Yuwei Zhang, Yueqiang Zhu, Yafei Wang, Mengran Zhao, Zhiran Liang, Zhiye Qu, Lu Yin, Hong Lu, Zhaoxiang Ye
Summary: This study compared the levels of background parenchymal enhancement (BPE) on contrast-enhanced cone-beam breast CT (CE-CBBCT) and MRI, evaluated inter-reader reliability, and analyzed the relationship between clinical factors and BPE levels on CE-CBBCT. The results showed substantial agreement and comparable inter-reader reliability between CE-CBBCT and MRI for BPE evaluation. The study also found a significant association between BPE level on CE-CBBCT and menstrual status, breast density, and previously treated breast cancer. For premenopausal patients, BPE level on CE-CBBCT was associated with the menstrual cycle, with lower levels in the second week.
EUROPEAN RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ichiro Ogura, Yoshiyuki Minami, Junya Ono, Yoriaki Kanri, Yasuo Okada, Kensuke Igarashi, Maiko Haga-Tsujimura, Ken Nakahara, Eizaburo Kobayashi
Summary: This study aimed to evaluate the CBCT imaging and histopathological characteristics of ORN and MRONJ, finding that MRONJ showed more frequent periosteal reaction and osteoclasts compared to ORN, suggesting the potential usefulness of CBCT for the evaluation of these conditions.
IMAGING SCIENCE IN DENTISTRY
(2021)
Article
Oncology
Yuxiang Liu, Bining Yang, Xinyuan Chen, Ji Zhu, Guangqian Ji, Yueping Liu, Bo Chen, Ningning Lu, Junlin Yi, Shulian Wang, Yexiong Li, Jianrong Dai, Kuo Men
Summary: This study developed efficient segmentation methods for MRIgART and CBCTgART, utilizing personalized modeling to improve the segmentation accuracy of adaptive radiotherapy (ART), and achieved better or comparable performance.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Franz Sebastian Schwindling, Alexander Juerchott, Sophia Boehm, Stefan Rues, Dorothea Kronsteiner, Sabine Heiland, Martin Bendszus, Peter Rammelsberg, Tim Hilgenfeld
Summary: The study measured the in vivo 3D accuracy of backward-planned partially guided implant surgery (PGIS) based on dental magnetic resonance imaging (dMRI). The results showed that while the 3D accuracy of dMRI-based PGIS was lower than CBCT-based PGIS, it still showed promising potential for facilitating backward planning without ionizing radiation.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Orthopedics
Lucas Wolharn, Roman Guggenberger, Kai Higashigaito, Thomas Sartoretti, Sebastian Winklhofer, Christine B. Chung, Tim Finkenstaedt
Summary: This study compared the value of zero echo time (ZTE) and gradient echo black bone (BB) MRI sequences with computed tomography (CT) as the reference standard for bone assessment of the sacroiliac joint (SI). The results showed that ZTE and BB had similar performance to CT in most features, with the exception of gas in the SI joint. These sequences may potentially serve as an alternative to CT without exposing patients to ionizing radiation.
SKELETAL RADIOLOGY
(2022)
Article
Medicine, General & Internal
Nils H. Ulrich, Jakob M. Burgstaller, Fabio Valeri, Giuseppe Pichierri, Michael Betz, Tamas F. Fekete, Maria M. Wertli, Francois Porchet, Johann Steurer, Mazda Farshad
Summary: This study analyzed the incidence of revision surgery and other outcome measures in patients undergoing different types of operations for degenerative lumbar spinal stenosis (DLSS). The results showed that there was no significant association between the type of index operation and the need for revision surgery.
Article
Clinical Neurology
Jonas M. Getzmann, Hamidreza Ashouri, Jakob M. Burgstaller, Fabio Valeri, Sebastian Winklhofer, Nils H. Ulrich, Roman Guggenberger
Summary: This study found that paraspinal fatty muscle infiltration (FMI) and cumulative lumbar spine degeneration have an influence on long-term clinical outcomes in patients with lumbar spinal canal stenosis (LSCS). Total lumbar spine degeneration is not associated with clinical symptoms, while FMI is associated with lower function and quality of life in LSCS patients.
Article
Neurosciences
Maximilian Scherer, Tianlu Wang, Robert Guggenberger, Luka Milosevic, Alireza Gharabaghi
Summary: Neural communication across different spatial and temporal scales is of great interest in clinical and basic science. The direct modulation index (dMI), a novel measure, provides an accurate and reliable estimate of phase-amplitude coupling (PAC), resistant to noise and suitable for small amounts of data. Comparisons with existing methods show that dMI outperforms them in estimating PAC and is robust to varying noise levels and signal lengths. Therefore, dMI allows for a reliable investigation of PAC, offering crucial insights into functional brain architecture in key contexts such as behavior and cognition.
HUMAN BRAIN MAPPING
(2023)
Article
Neuroimaging
Kevin Kern, Mathias Vukelic, Robert Guggenberger, Alireza Gharabaghi
Summary: Motor restoration after severe stroke is often limited. However, some severely impaired stroke patients still have rehabilitative potential. A study found that biomarkers can identify these patients and promote improvement in wrist movement through rehabilitation training using a brain-machine interface.
NEUROIMAGE-CLINICAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Malwina Kaniewska, Daniel Kuhn, Eva Deininger-Czermak, Lucas Wolharn, Tim Finkenstaedt, Roman Guggenberger
Summary: This study assessed the diagnostic performance of 3D zero-echo time (3D-ZTE) and 3D T1-weighted gradient-echo (3D-T1GRE) MRI sequences for evaluating lumbar facet joints (LFJs) and detecting lumbosacral transitional vertebrae (LSTV). The results showed that these two MRI sequences can provide comparable accuracy to CT and may serve as potential alternatives.
Article
Medicine, Research & Experimental
Lara Planas-Paz, Alicia Pliego-Mendieta, Catherine Hagedorn, Domingo Aguilera-Garcia, Martina Haberecker, Fabian Arnold, Marius Herzog, Lorenz Bankel, Roman Guggenberger, Sabrina Steiner, Yanjiang Chen, Abdullah Kahraman, Martin Zoche, Mark A. Rubin, Holger Moch, Christian Britschgi, Chantal Pauli
Summary: Defects in homologous recombination repair (HRR) in tumors are associated with poor prognosis and metastases development. This study focuses on sarcoma and reveals high levels of genomic instability signatures and molecular alterations in HRR genes in specific sarcoma entities. Sarcomas with HRDness traits show a distinct transcriptional signature and lack RAD51 nuclear foci formation upon DNA damage. The study also identifies the therapeutic vulnerability of WEE1 kinase in sarcomas with HRDness.
EMBO MOLECULAR MEDICINE
(2023)
Article
Orthopedics
Esin Rothenfluh, Sambhav Jain, Roman Guggenberger, William R. Taylor, Seyyed Hamed Hosseini Nasab
Summary: The study investigated the extent of scaphoid waist fracture union required to withstand physiological loads using a finite element model based on a CT scan. The results showed that at least 60% union is needed for biomechanical stability, and a quantitative CT scan analysis can guide clinicians to determine if mid-waist scaphoid fractures are truly united.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Article
Medicine, General & Internal
Malwina Kaniewska, Eva Deininger-Czermak, Maelene Lohezic, Falko Ensle, Roman Guggenberger
Summary: This study assessed the diagnostic performance of standard radial k-space (PROPELLER) MRI sequences and compared them with accelerated acquisitions combined with a deep learning-based convolutional neural network (DL-CNN) reconstruction for evaluation of the knee joint. The results showed that DL-CNN sequences had significantly higher image quality and diagnostic confidence compared to standard sequences. Both sequences performed similarly in the detection of knee-joint pathologies, but DL-CNN sequences were superior in evaluating retropatellar cartilage lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eva Deininger-Czermak, Dominic Gascho, Sabine Franckenberg, Pascal Kalin, Christian Bluthgen, Christina Villefort, Michael J. Thali, Roman Guggenberger
Summary: This study evaluated the added value of ultra-short echo time (UTE) and fast field echo resembling a CT using restricted echo-spacing (FRACTURE) MR sequences in the assessment of the osseous cervical spine. The results showed that compared to CT, the combination of UTE or FRACTURE sequences with standard MR sequences can provide comparable information on the cervical spine status, and can change the clinically significant stenosis grading.
Article
Radiology, Nuclear Medicine & Medical Imaging
Malwina Kaniewska, Eva Deininger-Czermak, Jonas M. Getzmann, Xinzeng Wang, Maelene Lohezic, Roman Guggenberger
Summary: Accelerated PROPELLER MRI sequences with DL post-processing showed superior image quality and higher diagnostic confidence compared to conventional sequences, particularly in assessing the pathologies of the subacromial bursa.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonas M. Getzmann, Florian A. Huber, Dominik Nakhostin, Eva Deininger-Czermak, Paul Schumann, Tim Finkenstaedt, Filippo Del Grande, Roman Guggenberger
Summary: This study assessed the impact of reducing the number of radial acquisitions on bone depiction quality in MRONJ using a UTE MR bone imaging sequence. The results showed that reducing the number of radial acquisitions decreased acquisition times and motion artifacts without compromising diagnostic performance. Quantitative analysis of image quality also revealed no significant differences between sequences.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Quemars M. Hamie, Florian A. Huber, Vincent Grunder, Tim Finkenstaedt, Magda Marcon, Erika Ulbrich, Nadja A. Farshad-Amacker, Roman Guggenberger
Summary: This study investigated the role of acromiohumeral distance (AHD) and critical shoulder angle (CSA) in predicting full thickness rotator cuff tendon tears (RCT) and critical fatty degeneration (CFD). The results showed that AHD and CSA were not dependent on age or sex, but there were significant differences between healthy and pathologic rotator cuffs. The combination of AHD and CSA (PIAHD-CSA) improved the diagnostic performance for predicting RCT and CFD.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2022)