Article
Cell Biology
Yan Li, Xian-li Sun, Chun-ling Ma, Chao Li, Ying Zhan, Wen-ting Li, Can Li, Yi-hao Wang
Summary: Abnormal trophoblast behaviors during pregnancy contribute to the development of preeclampsia (PE), with Syntaxin2 (STX2) identified as a crucial epithelial mediator in various diseases. This study aimed to explore the role of STX2 in trophoblast biology and unravel the molecular mechanisms underlying its involvement in PE. Results showed that STX2 expression was downregulated in placental tissues from women with PE compared to normal pregnancies, and further experiments revealed its interaction with the PI3K subunit p85, activating the AKT signaling pathway. These findings indicate a potential diagnostic tool and therapeutic target for treating PE.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Mei-Tsz Su, Ching-Wei Tsai, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai
Summary: This study demonstrates that elevated cellular FN expression in the placenta of preeclamptic patients is associated with the disease, while aspirin inhibits FN expression and reverses FN-mediated trophoblast functions, providing a drug mechanism for disease prevention and a target for preeclampsia intervention.
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Limei Yang, Le Hu, Hongyu Tang, Xuemei Chen, Xueqing Liu, Yue Zhang, Yixian Wen, Yongxiu Yang, Yanqing Geng
Summary: Ti3C2 MXene exposure impairs villus explant extension ability and trophoblast cell functions by inhibiting cell migration and invasion abilities, and enhancing autophagy. Inhibition of autophagy may be a potential therapeutic strategy for alleviating nanoparticle-induced placental toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Obstetrics & Gynecology
Mi Cheng, Zequn Liu, Wanqing Ji, Jie Zheng, Huiqian Zeng, Fang Guo, Ping He
Summary: This study demonstrated that tTG overexpression inhibited cell invasion, induced apoptosis, activated the PI3K/AKT signaling pathway, and reduced MMP-2 and MMP-9 expression. On the other hand, tTG knockdown significantly promoted cell proliferation and invasion, and inhibited apoptosis.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Fenglian Shi, Li Li
Summary: Our study aimed to explore the role of circ_0088196 (circular TNC [circTNC]) in trophoblast invasion and migration in preeclampsia (PE). The results showed that circTNC repressed cell invasion and migration by regulating the miR-525-5p/ABL1 axis and activating the PI3K/AKT pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell Biology
Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study reveals that downregulation of EGF can lead to poor trophoblast cell invasion by increasing KISS1 expression, which subsequently contributes to the pathogenesis of preeclampsia.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Obstetrics & Gynecology
Tingting Li, Sumei Wei, Conghong Fan, Dongmei Tang, Dan Luo
Summary: This study demonstrated that Nesfatin-1 promotes trophoblast cell proliferation, migration, invasion, and EMT while suppressing oxidative stress by activating the PI3K/AKT/mTOR and AKT/GSK3 beta signaling pathways, suggesting a potential therapeutic target for preeclampsia.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wen-Ting Yang, Mei Chen, Rui Xu, Peng-Sheng Zheng
Summary: PRDM4 inhibits cell proliferation and tumorigenesis in cervical cancer by regulating cell cycle progression and the activity of the PI3K/AKT signaling pathway.
Article
Biochemistry & Molecular Biology
Ruijing Chang, Yuan Su, Hongfang Kong, Fang Wang, Ying Xing, Lei Jiang, Hong Xin
Summary: This study indicates that disturbance of SEMP1 expression is associated with preeclampsia. SEMP1 levels were found to be downregulated in placental tissues of PE patients. Overexpression of SEMP1 enhanced the capability of trophoblast cells in proliferation, migration, and invasion.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Developmental Biology
Rui Tang, Zhilei Zhang, Wenjun Han
Summary: The study demonstrated that circLRRK1 was significantly upregulated in PE patients, and silencing circLRRK1 enhanced the proliferation, migration, and invasion of trophoblast cells. CircLRRK1 could target miR-223-3p, and overexpression of miR-223-3p also promoted the proliferation, migration, and invasion of trophoblast cells. CircLRRK1 regulated the PI3K/AKT signaling pathway by targeting miR-223-3p to suppress the progression of PE.
Article
Medicine, General & Internal
Xiaoying Wei, Yichong Yuan, Qiong Yang
Summary: This study found that lncRNA SNHG22 was downregulated in patients with preeclampsia. Overexpression of SNHG22 promoted migration and invasion of trophoblasts, while depletion of SNHG22 had a suppressive effect. The study demonstrated that SNHG22 regulates miR-128-3p and identified PCDH11X as the target gene of miR-128-3p. Furthermore, SNHG22 was found to promote migration and invasion of trophoblast cells in a miR-128-3p/PCDH11X dependent manner, and SNHG22 silencing weakened the activation of the PCDH11X-mediated PI3K/Akt signaling pathway, preventing migration and invasion of trophoblasts.
Article
Multidisciplinary Sciences
Xiaopei Hao, Yao Zhang, Yiwei Lu, Guoyong Han, Dawei Rong, Guoqiang Sun, Guangshun Sun, Weiwei Tang, Jindao Wu, Xuehao Wang
Summary: STK39 is overexpressed in cholangiocarcinoma (CCA) and negatively associated with patient prognosis. Knockdown of STK39 suppresses cell proliferation, migration, and invasion, while overexpression promotes tumor aggressiveness. Mechanistically, STK39 enhances CCA progression through activating the PI3K/AKT signaling pathway and inducing gemcitabine resistance. Additionally, the dysregulation of miR-26a-5p may mediate the increased expression of STK39.
Article
Developmental Biology
Pingsong Jin, Yijie Zhou, Zheng Liu, Xuehai Chen, Hongbo Qi
Summary: This study investigated the role of Claudin-1 (CLDN1) in trophoblast invasion and endovascular trophoblast (enEVT) differentiation in early-onset preeclampsia (EOPE). The expression and localization of CLDN1 were examined in normal and EOPE placental tissues. Trophoblast invasion and enEVT differentiation were studied using trophoblast cell lines. The results suggest that downregulation of CLDN1 is involved in the pathogenesis of EOPE by regulating trophoblast invasion and enEVT differentiation.
Article
Developmental Biology
Jian Zhao, Haigang Ding, Jinlong Ding, Xiaoliang Shi, Yao He, Hongdan Zhu, Hua Yuan, Tao Zhang, Juan Zhang
Summary: The METTL3-MYLK axis plays an important role in trophoblast invasion.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)