Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 77, Issue -, Pages 20-26Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2015.07.030
Keywords
Hepatocellular carcinoma (HCC); miR-670-5p; PROX1; Proliferation
Funding
- Science and Technology Development Plan Project of Jining Traditional Chinese Medicine [LC2012016]
- Teaching Reformation Project of Jining Medical University [14010]
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MiRNAs, as oncogenes or as anti-oncogenes, play critically regulated roles in human cancers at posttranscriptional level. A number of dysregulated miRNAs has been observed in HCC. However, the expression and function of miR-670-5p have not been evaluated in HCC to date. In this study, we examined and confirmed the over-expression of miR-670-5p in HCC and in hepatoma-derived cells Hep3B. At least 60% of HCC tissues showed a greater than three-fold enhance in the expression of miR-670-5p compared with paired adjacent non-cancerous tissues. Knockdown studies for miR-670-5p showed that the expression of miR-670-5p promoted cellular proliferation. In tissues and cells with high expression of miR-670-5p, decreased expression of PROX1, a miR-670-5p predicated target, was detected. It confirmed that PROX1 expression was obviously affected by the expression of miR-670-5p. Furthermore, overexpression of PROX1 greatly inhibitted cellular proliferation. Therefore, it was inferred that miR-670-5p may play important roles in enhancing proliferation activity that is associated with HCC by modulating PROX1 expression at posttranscriptional level. (C) 2015 Published by Elsevier Masson SAS.
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