Article
Biochemistry & Molecular Biology
Anna Hucke, Rita Schroeter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli
Summary: CDDP is an efficient chemotherapeutic agent, but it has significant unwanted side effects. This study suggests that OCT may play a role in causing these side effects by facilitating the uptake of CDDP. Mice lacking the OCT2 gene showed reduced kidney and neurological impairments compared to wild-type mice. OCT could be potential targets for reducing unwanted side effects and improving CDDP anticancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Julia Jimenez-Lopez, Inmaculada Bravo-Caparros, Laura Cabeza, Francisco R. Nieto, Rail Ortiz, Gloria Perazzoli, Eduardo Fernandez-Segura, Francisco J. Canizares, Jose M. Baeyens, Consolacion Melguizo, Jose Prados
Summary: The study found that encapsulating paclitaxel in large cationic liposomes can avoid peripheral neurotoxicity and improve the drug's anti-tumor effects on lung cancer. These liposomes not only show good biocompatibility, but also more effectively target cancer stem cells and tumors, reducing the painful peripheral neuropathy caused by the drug.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Anesthesiology
Emerson Krock, Carlos E. Morado-Urbina, Joana Menezes, Matthew A. Hunt, Angelica Sandstroem, Diana Kadetoff, Jeanette Tour, Vivek Verma, Kim Kultima, Lisbet Haglund, Carolina B. Meloto, Luda Diatchenko, Eva Kosek, Camilla I. Svensson
Summary: Transferring fibromyalgia patient immunoglobulin G (IgG) to mice induces pain-like behavior, indicating the potential role of autoantibodies in fibromyalgia pathology. Elevated levels of anti-SGC IgG were found in fibromyalgia patients and were associated with more severe symptoms. Screening for anti-SGC antibodies could help personalize treatment options for fibromyalgia.
Article
Medicine, Research & Experimental
Moustafa S. Abdelhamid, Khlood M. El Bohi, Mohamed H. Sherif, Manar S. Abdelhamid, Mohamed M. Abdel-Daim, Yaser H. A. Elewa, Mohamed M. M. Metwally, Ghadeer M. Albadrani, Agnieszka Najda, Shereen El Abdel-Hamid, Ehsan H. Abu-Zeid
Summary: This study aimed to assess the ameliorative effect of bee venom (BV) on MeHgCl-induced peripheral neurotoxicity using DRGs in rats. The results showed that BV administration significantly mitigated the MeHgCl-induced alterations in oxidative stress-related indices and protected against MeHgCl-induced neuronal damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Neurosciences
Wen-Long Qiao, Qing-Rui Qin, Qing Li, Jia-Wei Hao, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: P2X3 receptors and group II mGluRs are expressed in primary sensory neurons. Activation of group II mGluRs inhibits the electrophysiological activity of P2X3 receptors. LY354740, a group II mGluR agonist, decreases the inward currents mediated by P2X3 receptors in rat DRG neurons.
Article
Geriatrics & Gerontology
Yuting Ding, Wenkang Luan, Xuanlin Shen, Zhe Wang, Yongjun Cao
Summary: This study found that BDNF-AS is upregulated in patients with AD and may be associated with cognitive status. BDNF-AS can promote neurotoxicity by competitively binding to miR-9-5p to promote the expression of BACE1, thereby promoting amyloid deposition. High expression of BDNF-AS aggravates cognitive impairment in AD mice.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Stephen N. Housley, Travis M. Rotterman, Paul Nardelli, Dario I. Carrasco, Richard K. Noel, Laura O'Farrell, Timothy C. Cope
Summary: The study quantitatively evaluated neural tissue exposed to oxaliplatin (OX) in vivo, finding that the intraperitoneal (IP) route of administration achieves clinically relevant pharmacokinetic exposure in a rodent model of CIN.
Article
Biochemistry & Molecular Biology
Cristina Fraquelli, Jasmine Hauzinger, Christian Humpel, Maria Nolano, Vincenzo Provitera, Vinay Kumar Sharma, Peng Loh, Zenon Pidsudko, Georgios Blatsios, Josef Troger
Summary: This study investigated the presence and source of serpinins in the skin, and found that serpinin was present in the dorsal root ganglia and sensory nerves of rats, with colocalization with substance P. Although predominantly found in its free form in the skin, the serpinins may have functional significance in the sensory innervation of the skin.
Article
Biochemistry & Molecular Biology
Ruirui Lu, Katharina Metzner, Fangyuan Zhou, Cathrin Flauaus, Annika Balzulat, Patrick Engel, Jonas Petersen, Rebekka Ehinger, Anne Bausch, Peter Ruth, Robert Lukowski, Achim Schmidtko
Summary: The sodium-activated potassium channel Slack plays a role in sensory neurons and is involved in mediating sodium-activated potassium current (I-KNa) and modulating neuronal activity. Studies found that Slack activity is reduced in sensory neurons after peripheral nerve injury, contributing to neuropathic pain hypersensitivity, and that it is associated with ATP-sensitive P2X3 receptors. Experiments showed that Slack-mediated I-KNa can be bidirectionally modulated in response to P2X3 activation, suggesting a potential novel strategy for treating neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jia-wen Xu, Xu Xu, Yun Ling, Yan-chun Wang, Yu-jie Huang, Juan-zhen Yang, Jia-ying Wang, Xu Shen
Summary: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes without cure. In this study, the therapeutic potential of vincamine (Vin), a GPR40 agonist, in ameliorating DPN-like pathology was evaluated in diabetic mice. The results showed that Vin administration improved neurological dysfunctions, blood flow velocities, blood perfusion areas, myelin sheath injury, and intraepidermal nerve fiber density impairment in DPN mice, suggesting that pharmacological activation of GPR40 could be a promising therapeutic strategy for DPN.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medicine, Research & Experimental
Ying Zhao, Qiang Wang, Chen Xie, Yuling Cai, Xue Chen, Yuhui Hou, Liu He, Jianping Li, Min Yao, Shuangxi Chen, Wutian Wu, Xiaojia Chen, An Hong
Summary: This study developed a novel low-molecular-weight peptide agonist CH02 targeting FGFR, which effectively promoted nerve regeneration, enhanced axon growth of sensory neurons, and robustly improved nerve regeneration and sensory-motor behavioral recovery in a rat spinal dorsal root injury model.
Article
Biochemical Research Methods
Aseer Intisar, Seung Joon Lee, Yu-Gyeong Kim, Woon-Hae Kim, Hyun Young Shin, Min Young Kim, Jong Man Kim, Jungmin Lee, Yun Jeoung Mo, Yu Seon Kim, Seung-Hoon Kim, Yun-Il Lee, Minseok S. Kim
Summary: This study introduces a rapid method for enriching neurons from the mouse embryonic dorsal root ganglion using fully-automated continuous centrifugal microfluidics, achieving effective isolation within 13 minutes. The purified neurons showed improved viability and purity compared to conventional chemical purification methods, highlighting the potential of this automated system to advance neurological research.
Article
Cell Biology
Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Summary: The study reveals that Slack serves as a modulator of TRPA1-mediated activation of sensory neurons, but not TRPV1-mediated activation.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
