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Biochemistry & Molecular Biology
Sofia Spataro, Concetta Guerra, Andrea Cavalli, Jacopo Sgrignani, Jonathan Sleeman, Lina Poulain, Andreas Boland, Leonardo Scapozza, Solange Moll, Marco Prunotto
Summary: CEMIP, also known as KIAA1199 or HYBID, is a protein involved in the depolymerization of hyaluronic acid and has been shown to play a key role in tumor progression and various inflammatory diseases. Despite its association with these diseases, the biology of CEMIP remains elusive. This review article summarizes the scientific evidence regarding its structure, function, and expression, aiming to shed light on the protein's role in inflammation-related conditions.
Article
Biochemistry & Molecular Biology
Anja Schmaus, Melanie Rothley, Caroline Schreiber, Stephanie Moeller, Sven Rosswag, Sandra Franz, Boyan K. Garvalov, Wilko Thiele, Sofia Spataro, Carsten Herskind, Marco Prunotto, Ulf Anderegg, Matthias Schnabelrauch, Jonathan Sleeman
Summary: This study reveals the importance of CEMIP, a hyaluronidase enzyme, in the metabolism, proliferation, and differentiation of fibroblasts. Inhibiting CEMIP with a compound called sHA3.7 increases cellular levels of hyaluronan and promotes fibroblast differentiation into myofibroblasts.
Article
Biochemistry & Molecular Biology
Jiarui Zhang, Yoshihiro Nishida, Hiroshi Koike, Lisheng Zhuo, Kan Ito, Kunihiro Ikuta, Tomohisa Sakai, Shiro Imagama
Summary: This study aimed to investigate the effects of ipriflavone on the development and progression of osteoarthritis (OA) by reducing KIAA1199 activity. The results showed that ipriflavone could suppress OA onset and progression by targeting KIAA1199 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shinya Sato, Yukiko Mizutani, Yuta Yoshino, Manami Masuda, Megumi Miyazaki, Hideaki Hara, Shintaro Inoue
Summary: The study showed that a mixture of pro-inflammatory cytokines negatively regulates hyaluronan (HA) metabolism in skin by suppressing HYBID and promoting HAS2, with HA synthesis mainly driven by IL-1 beta.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jun Shiozawa, Susana de Vega, Chiho Yoshinaga, Xang Ji, Yoshifumi Negishi, Masahiro Momoeda, Tomomi Nakamura, Hiroyuki Yoshida, Haruka Kaneko, Muneaki Ishijima, Yasunori Okada
Summary: Destruction of articular cartilage in osteoarthritis is caused by the loss of the hyaluronan-aggrecan network and degradation of collagen fibrils. This study found that the HA-binding protein HYBID is overexpressed in osteoarthritis cartilage, and its expression is up-regulated by interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). In contrast, the expression of the transmembrane protein TMEM2 is not significantly different in osteoarthritis cartilage. HYBID plays a role in HA degradation, while TMEM2 has negligible HA-degrading activity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shuko Terazawa, Mariko Takada, Yoriko Sato, Hiroaki Nakajima, Genji Imokawa
Summary: This study found that UVA radiation decreases the secretion of HA by HDFs due to the regulation of HAS2 and HYBID expression levels, mainly attributed to the inactivated signaling of the STAT3 axis and the activated signaling of the p38/ATF2 axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dimitris Kokoretsis, Evangelia-Konstantina Maniaki, Konstantina Kyriakopoulou, Christos Koutsakis, Zoi Piperigkou, Nikos K. Karamanos
Summary: This article highlights the vital functions of hyaluronan (HA) in cancer cell initiation, progression, and immune response, as well as its paracrine interactions with stromal cells. Furthermore, it discusses the important role of HA in the formation of pre-metastatic niche, which may contribute to the improvement of current theranostic approaches for cancer management.
Article
Genetics & Heredity
Wendena S. Parkes, Farners Amargant, Luhan T. Zhou, Cecilia E. Villanueva, Francesca E. Duncan, Michele T. Pritchard
Summary: The extracellular matrix (ECM) of the ovarian stroma, consisting of collagen and hyaluronan (HA), varies in content, molecular weight, and gene transcripts among different mammalian species. These differences have implications for the composition, organization, and regulation of the ovarian ECM in large mammalian species, including humans.
Article
Multidisciplinary Sciences
Ting Xie, Vrishika Kulur, Ningshan Liu, Nan Deng, Yizhou Wang, Simon Coyle Rowan, Changfu Yao, Guanling Huang, Xue Liu, Forough Taghavifar, Jiurong Liang, Cory Hogaboam, Barry Stripp, Peter Chen, Dianhua Jiang, Paul W. Noble
Summary: Recent studies have shown that impaired renewal of type 2 alveolar epithelial cells (ATII) in IPF patients and mice with defective ATII can lead to severe pulmonary fibrosis. Growth hormone receptor (GHR) expression, mainly found in mesenchymal cells, is significantly decreased in IPF lungs, but higher levels of GHR expression are associated with better lung function in IPF patients. The findings suggest that a previously unidentified mesenchymal paracrine signaling via GHR can support ATII progenitor cell renewal and limit the severity of lung fibrosis.
Article
Cell Biology
Janne Capra, Kai Harkonen, Heikki Kyykallio, Helena Vihinen, Eija Jokitalo, Kirsi Rilla
Summary: We used high-resolution imaging techniques to characterize the size and morphology of extracellular vesicles produced by breast cancer cells. The results showed diverse morphology of these vesicles and emphasized the importance of comparing different methods.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)