Review
Polymer Science
Sibusiso Alven, Blessing Atim Aderibigbe
Summary: The management of chronic wounds is challenging due to factors such as malnutrition, diseases, and bacterial infection. Wound dressings formulated from a combination of biopolymers and synthetic polymers show promising properties, especially when prepared using electrospinning technique.
Article
Chemistry, Multidisciplinary
Mingchao Sun, Shaojuan Chen, Peixue Ling, Jianwei Ma, Shaohua Wu
Summary: This study successfully fabricated methacrylated gelatin/poly(L-lactic acid) hybrid nanofiber mats and demonstrated their excellent hydrophilic properties and high water absorption capacity. The UV crosslinking process significantly improved the structural stability and mechanical properties of the nanofiber mats. Crosslinked nanofiber mats with higher MeGel content showed enhanced attachment, growth, and proliferation of human dermal fibroblasts.
Article
Biochemistry & Molecular Biology
Fatemeh Shahverdi, Aboulfazl Barati, Ehsan Salehi, Mohammad Arjomandzadegan
Summary: A two-nozzle electrospinning method was used to fabricate hybrid nanofibers based on chitosan/polyvinyl alcohol and poly (epsilon-caprolactone), with CeAlO3 nanoparticles incorporated to improve the nanofiber's properties. The addition of CeAlO3 nanoparticles increased the crystallinity, tensile strength, and modulus of the nanofibers without affecting their biocompatibility. The prepared nanofibers have the potential to be a low-cost and effective wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Pathum Chandika, Fazlurrahman Khan, Seong-Yong Heo, Tae -Hee Kim, Young-Mog Kim, Myunggi Yi, Won-Kyo Jung
Summary: In this study, chitooligosaccharide/sinapic acid conjugate and photo cross-linkable hyaluronic acid were successfully synthesized and encapsulated in dual cross-linked polyvinyl alcohol/methacrylated hyaluronic acid composite hydrogel for full-thickness wound healing application. The composite hydrogel exhibited excellent physical and mechanical properties, and the introduction of the conjugate significantly enhanced its biocompatibility, antioxidant, and antimicrobial properties, thereby promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Hamidreza Motasadizadeh, Sara Azizi, Alireza Shaabani, Mostafa Ghodrati Sarvestani, Roya Sedghi, Rassoul Dinarvand
Summary: A novel wound healing system with multifunctional properties was prepared in this study, showing excellent mechanical, structural, and biological properties. The CS-g-PNVIM-based nanofibers exhibited promising potential for biocompatible antibacterial wound dressing applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Laura Tamayo, Paula Santana, Juan C. Forero, Matias Leal, Nicolas Gonzalez, Mauricio Diaz, Nicolas Guiliani, Eugenio Hamm, Marcela Urzua
Summary: The prevalence of chronic and acute wounds presents a challenge for health systems globally. A new study has developed a wound dressing material that releases active agents to prevent infection and promote healing. The material effectively inhibits bacterial growth and promotes fibroblast cell proliferation, making it suitable for non-adherent wound dressings.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Bialik-Was, Klaudia Pluta, Dagmara Malina, Mateusz Barczewski, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
Summary: The study demonstrates that increasing glycerin content significantly decreases gel fraction and thermal resistance, while also reducing water absorption capacity. However, it does not affect cytotoxicity and elongation properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Textiles
Tittaya Thairin, Patcharaporn Wutticharoenmongkol
Summary: The electrospun CIP-loaded alginate/poly (vinyl alcohol)/gelatin (SPG) nanofiber mats exhibited excellent release properties and antimicrobial activity, making them potentially promising materials for wound healing applications.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Engineering, Biomedical
Ipek Canatar, Okan Zenger, Sibel Ozdas, Gozde Baydemir Pesint
Summary: In this study, PVA-Gel/PTS cryogel membranes were synthesized as wound dressing materials. The physicochemical properties of PVA-Gel and PVA-Gel/PTS were characterized, and cell experiments showed that PVA-Gel/PTS promoted cell proliferation and viability, indicating its potential application in wound healing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Polymer Science
Nadia Sueli Vieira Capanema, Alexandra Ancelmo Piscitelli Mansur, Isadora Cota Carvalho, Sandhra Maria Carvalho, Herman Sander Mansur
Summary: The study reports the synthesis and characterization of hybrid hydrogels for wound dressings using a water-responsive system. These hydrogels demonstrated tunable physicochemical properties and were produced through an eco-friendly process. The hydrogels showed high absorbency and cytocompatibility, making them suitable for chronic wound healing and skin tissue engineering applications.
Article
Polymer Science
Jia Liang, Honglin Chen, Zhengchao Guo, Piet Dijkstra, Dirk Grijpma, Andre Poot
Summary: Hybrid fibrous mats composed of PTMC-tMA and GelMA were prepared by electrospinning and photo-crosslinking, showing good cell adhesive properties and high toughness.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Hakimeh Ziyadi, Mitra Baghali, Mina Bagherianfar, Fatemeh Mehrali, Reza Faridi-Majidi
Summary: This study investigated parameters affecting the electrospinning of PVA/kefiran composite nanofibers. The optimal condition for nanofiber fabrication was found to be 18 kV, 200 mm, and 1 mL/h, producing uniform nanofibers without knots or adhesion. Concentration was identified as the most effective parameter influencing the diameter of nanofibers, and phase separation did not occur between the two polymers according to TEM images.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2021)
Review
Polymer Science
Chang Huang, Xizi Xu, Junhao Fu, Deng-Guang Yu, Yanbo Liu
Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)