4.7 Article

Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 138, Issue -, Pages 244-251

Publisher

ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.07.030

Keywords

Ferulic acid; Intestinal permeation; Zein nanoparticles

Funding

  1. Coordenacdo de Aperfeicoamento de Pessoal de Nivel Superior - CAPES/Brazil [88881.133790/2016-01 PDSE]
  2. Fundacao Araucaria, PR/Brazil [17/17]
  3. Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000012]
  4. FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020
  5. Portuguese funds through FCT- Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Ensino Superior [POCI-01-0145-FEDER-007274]
  6. Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [SFRH/BD/118721/2016]
  7. Fundação para a Ciência e a Tecnologia [SFRH/BD/118721/2016] Funding Source: FCT

Ask authors/readers for more resources

The objective of this study was to develop zein-casein-lysine nanoparticles to modulate the intestinal permeability of ferulic acid (FA), a bioactive compound with proven antioxidant properties. The nanoparticles were obtained by a liquid-liquid dispersion method and were characterized in terms of mean size, polydispersity index, zeta potential, association efficiency (AE), in vitro drug release, x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The in vitro intestinal permeability of nanoparticles was evaluated through Caco-2 and Caco-2/HT29-MTX monoculture and co-culture models, respectively. Nanoparticles presented a mean size of 199 nm and zeta potential of -26 mV. The AE of FA was 23% evaluated by high-performance liquid chromatography (HPLC). XRD showed amorphization of FA after association and FT-IR showed no changes in chemical structures of the compounds after nanoencapsulation. The cytotoxicity assays demonstrated that multicomposite nanoparticles presented a safe profile against Caco-2 and HT29-MTX cells. In the in vitro permeability assay, free FA exhibited higher permeability compared to FA-loaded nanoparticles, possibly due to prolonged FA release from nanoparticles. These new developed zein-casein-lysine nanoparticles may be used for FA sustained delivery by the oral route. (C) 2019 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Pharmacology & Pharmacy

Recent advances in long-acting drug delivery systems for anticancer drug

Catarina Pacheco, Ana Baiao, Tao Ding, Wenguo Cui, Bruno Sarmento

Summary: The systemic use of chemotherapy for cancer treatment is limited by its toxicity. Drug delivery systems (DDSs) have been designed to avoid systemic toxicity by protecting drugs and controlling drug release. However, the approval of tailored DDSs for clinical use is minimal due to the need for improvement in safety and in vivo activity.

ADVANCED DRUG DELIVERY REVIEWS (2023)

Article Instruments & Instrumentation

Functionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides

Fatima Hameedat, Soraia Pinto, Joana Marques, Sofia Dias, Bruno Sarmento

Summary: Peptides have great potential for treating chronic conditions and there are more than 80 peptides available in the global market. However, most of the marketed peptide drugs are administered intravenously or subcutaneously due to their fast degradation and limited absorption through non-invasive routes. In this study, candidate protein delivery systems for pulmonary administration of peptides were developed and characterized. The targeted PEGylated zein nanoparticles (ZNPs) showed promising results in enhancing insulin permeability and are suitable as peptide carriers for pulmonary delivery.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2023)

Article Instruments & Instrumentation

Multifunctional nanomedicine strategies to manage brain diseases

Paulo Faria, Catarina Pacheco, Rui Pedro Moura, Bruno Sarmento, Claudia Martins

Summary: Brain diseases pose a significant social and economic burden, and their complexity makes single-drug therapies insufficient. Nanomedicine, with its ability to target the brain and deliver multiple cargos, shows promise in overcoming therapeutic resistance. This review explores the mechanisms of therapeutic resistance in brain diseases, the use of multifunctional nanomedicines to tackle multiple aspects of the disease microenvironment, and the promising therapeutic responses achieved by cutting-edge multifunctional nanomedicines.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2023)

Review Pharmacology & Pharmacy

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

Lais de Almeida Campos, Margani Taise Fin, Kelvin Sousa Santos, Marcos William de Lima Gualque, Ana Karla Lima Freire Cabral, Najeh Maissar Khalil, Ana Marisa Fusco-Almeida, Rubiana Mara Mainardes, Maria Jose Soares Mendes-Giannini

Summary: Invasive fungal infections have become a significant cause of mortality and morbidity worldwide. The current treatment options are limited due to low bioavailability and toxicity. Voriconazole is widely used to treat various fungal infections, but its non-linear pharmacokinetics and individual variations in metabolism can lead to supratherapeutic doses and increased toxicity. Recent research has explored the use of nanotechnology-based drug delivery systems to improve the delivery of voriconazole. These systems have shown promising results in enhancing drug permeation and deposition in target tissues, allowing for controlled and sustained release in different administration routes. Overall, nanotechnology-based drug delivery systems offer a more effective and safer alternative for treating fungal infections.

PHARMACEUTICS (2023)

Article Pharmacology & Pharmacy

Multicellular Quadruple Colorectal Cancer Spheroids as an In Vitro Tool for Antiangiogenic Potential Evaluation of Nanoparticles

Suzana Carvalho, Maria Jose Silveira, Mariana Domingues, Barbara Ferreira, Catarina Leite Pereira, Maria Palmira Gremiao, Bruno Sarmento

Summary: This study proposes a multicellular spheroid model of colorectal cancer (CRC) for screening the antiangiogenic potential of novel nanomedicines. The developed model consists of HCT116 cells, human pulmonary microvascular endothelial cell (HPMEC), fibroblasts, and macrophages. It exhibits intrinsic CRC features and shows that Gellan gum/chitosan nanoparticles encapsulating BVZ have superior antiangiogenic properties compared to free BVZ.

ADVANCED THERAPEUTICS (2023)

Article Nanoscience & Nanotechnology

Exploring Low-Power Single-Pulsed Laser-Triggered Two-Photon Photodynamic/Photothermal Combination Therapy Using a Gold Nanostar/Graphene Quantum Dot Nanohybrid

Amir Soleimany, Sepideh Khoee, Sofia Dias, Bruno Sarmento

Summary: In this study, a new nanohybrid consisting of thiolated chitosan-coated gold nanostars (AuNS-TCS) as the photothermal agent and riboflavin-conjugated N,S-doped graphene quantum dot (Rf-N,S-GQD) as the two-photon photosensitizer (TP-PS) was developed. The nanohybrid exhibited combined TP-PDT/PTT when a low-power, single-pulsed laser irradiation was applied. The study demonstrates a successful single-laser-triggered, synergistic combined TP-PDT/PTT based on a plasmonic metal/QD hybrid, with potential for future investigation in clinical settings.

ACS APPLIED MATERIALS & INTERFACES (2023)

Article Chemistry, Applied

Appraisal of a new potential antioxidants-rich nutraceutical ingredient from chestnut shells through in-vivo assays-A targeted metabolomic approach in phenolic compounds

Diana Pinto, Andreia Almeida, Anallely Lopez-Yerena, Soraia Pinto, Bruno Sarmento, Rosa Lamuela-Raventos, Anna Vallverdu-Queralt, Cristina Delerue-Matos, Francisca Rodrigues

Summary: This study demonstrates the in-vivo antioxidant properties of chestnut shell extract, as well as its protective effects against hemolysis and elevated blood glucose and lipids levels. Additionally, the study provides new insights on the metabolomic profiling of polyphenols.

FOOD CHEMISTRY (2023)

Review Environmental Sciences

In vitro data for fire pollutants: contribution of studies using human cell models towards firefighters' occupational

Maria Joao Bessa, Bruno Sarmento, Marta Oliveira, Francisca Rodrigues

Summary: Firefighters are exposed to health-relevant pollutants released during fires, and in vitro studies using human cell models have shown decreased viability, increased oxidative stress, elevated pro-inflammatory cytokines levels, and increased cell death frequencies. However, more research is needed to understand the toxicity mechanisms initiated by firefighting activities and establish occupational exposure limits for firefighters.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2023)

Article Instruments & Instrumentation

Zein nanoparticles as oral carrier for mometasone furoate delivery

Priscila Zimath, Soraia Pinto, Sofia Dias, Alex Rafacho, Bruno Sarmento

Summary: This study loaded MF into zein NPs and evaluated the potential advantages of oral delivery and the application in treating intestinal inflammatory diseases.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2023)

Review Pharmacology & Pharmacy

Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds

Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Duran-Lara, Simon J. Clark, Simo Schwartz

Summary: Slow-release delivery systems are crucial for long-term sustained treatments of retinal diseases. Hydrogels, especially temperature-responsive hydrogels, have been studied as promising delivery vehicles for intravitreal injection of retinal therapies.

PHARMACEUTICS (2023)

Article Engineering, Biomedical

Nanoparticles targeting Sialyl-Tn for efficient tyrosine kinase inhibitor delivery in gastric cancer

Francisca Diniz, Sofia Lamas, Hugo Osorio, Paulo Aguiar, Daniela Freitas, Fatima Gartner, Bruno Sarmento, Celso A. Reis, Joana Gomes

Summary: This study demonstrates the potential of using nanoparticles targeting STn for delivering FRT as a therapeutic approach in gastric cancer. The nanoparticles effectively reduced tumor growth, cell proliferation, and tumor necrosis in vivo.

ACTA BIOMATERIALIA (2023)

Article Engineering, Biomedical

Abdominal wall hernia repair: from prosthetic meshes to smart materials

Qimanguli Saiding, Yiyao Chen, Juan Wang, Catarina Leite Pereira, Bruno Sarmento, Wenguo Cui, Xinliang Chen

Summary: Hernia reconstruction is a frequently performed surgical procedure that has been greatly improved by plastic surgery techniques. Surgical meshes are commonly used for abdominal wall hernia repair, but there are still challenges in mesh design and complications. This review provides a comprehensive summary of hernia surgical mesh development, including commercial meshes, prosthetic materials, and engineered prosthetics. The review also outlines future research directions for successful hernia repair solutions.

MATERIALS TODAY BIO (2023)

Article Chemistry, Medicinal

Targeting β Cells with Cathelicidin Nanomedicines Improves Insulin Function and Pancreas Regeneration in Type 1 Diabetic Rats

Cecilia Cristelo, Rute Nunes, Soraia Pinto, Joana Moreira Marques, Francisco Miguel Gama, Bruno Sarmento

Summary: This study successfully loaded the LLKKK18 peptide onto PLGA nanoparticles and demonstrated the targeted delivery to beta cells, as well as the promotion of insulin release and increase in beta cell mass. This research provides insights for new therapeutic approaches in T1D treatment.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2023)

Review Pharmacology & Pharmacy

Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance

Andrea Cunha, Patricia M. A. Silva, Bruno Sarmento, Odilia Queiros

Summary: The Warburg effect is a metabolic shift that leads to acidification of the tumor microenvironment and increased drug resistance. The metabolic differences between cancer and normal cells provide a strategy for new therapies, and nanodrug delivery systems can overcome multidrug resistance.

PHARMACEUTICS (2023)

Review Chemistry, Multidisciplinary

The Material World of 3D-Bioprinted and Microfluidic-Chip Models of Human Liver Fibrosis

Ana Margarida Carvalho, Ruchi Bansal, Cristina C. Barrias, Bruno Sarmento

Summary: Biomaterials are crucial for creating in vitro models of human liver fibrosis, as they allow for a more accurate replication of cell-matrix interactions. These models can provide insights into the development and treatment of liver disease.

ADVANCED MATERIALS (2023)

Article Biochemistry & Molecular Biology

Effects of aging and diabetes on the deformation mechanisms and molecular structural characteristics of collagen fibrils under daily activity

Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang

Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Tea polyphenols protect against Flavobacterium columnare-induced gill injury via suppression of oxidative stress, inflammation, and apoptosis in grass carp

Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng

Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer

Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng

Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

Cellular and physiological roles of sigma factors in Vibrio spp.: A comprehensive review

Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim

Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

An eco-friendly composite hydrogel based on covalently crosslinked cellulose/poly (glycerol citrate) for thallium (І) removal from aqueous solutions

Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati

Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Enzyme-triggered approach to reduce water bodies' contamination using peroxidase-immobilized ZnO/SnO2/alginate nanocomposite

Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal

Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Bacterial cellulose microfiber reinforced hollow chitosan beads decorated with cross-linked melamine plates for the removal of the Congo red

Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri

Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Necrotic activity of ExhC from Mammaliicoccus sciuri is mediated by specific amino acid residues

Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti

Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Silk-hydrogel functionalized with human decellularized Wharton's jelly extracellular matrix as a minimally invasive injectable hydrogel system for potential nucleus pulposus tissue replacement therapy

Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal

Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

A uniform-unsaturated crosslinking strategy to construct injectable alginate hydrogel

Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma

Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

α-Tocopherol-loaded multi-layer nanoemulsion using chitosan, and dextran sulfate: Cellular uptake, antioxidant activity, and in vitro bioaccessibility

Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee

Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Stabilization of oil-in-water high internal phase emulsions with octenyl succinic acid starch and beeswax oleogel

Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao

Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

A review for the correlation between optic atrophy 1-dependent mitochondrial fusion and cardiovascular disorders

Bi-Feng Yao, Xiu-Ju Luo, Jun Peng

Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

Nanomaterials for detection of biomolecules and delivering therapeutic agents in theragnosis: A review

Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park

Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Preparation and characterization of hemicellulose films reinforced with amino polyhedral oligomeric silsesquioxane for biodegradable packaging

Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan

Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)