Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition andβ2-AR agonizing activities

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

(2015) Grazia Graziani et al.   BIOCHEMICAL PHARMACOLOGY

New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease

(2015) Xiao-Ting Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development and validation of an UPLC-MS/MS method for the quantification of ethoxzolamide in blood, brain tissue, and bioequivalent buffers: Applications to absorption, brain distribution, and pharmacokinetic studies

(2015) Song Gao et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pharmacokinetic studies of ginkgolide K in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry

(2015) Zhi-Ying Fan et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Anti-inflammatory effects of Crataeva nurvala Buch. Ham. are mediated via inactivation of ERK but not NF-κB

(2015) Young-Chang Cho et al.   JOURNAL OF ETHNOPHARMACOLOGY

Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs

(2015) Lin Tao et al.   PHARMACOLOGICAL RESEARCH

Influence of seasonal variation on Thymus longicaulis C. Presl chemical composition and its antioxidant and anti-inflammatory properties

(2014) Silvia Galasso et al.   PHYTOCHEMISTRY

Biological ingredient analysis of traditional Chinese medicine preparation based on high-throughput sequencing: the story for Liuwei Dihuang Wan

(2014) Xinwei Cheng et al.   Scientific Reports

Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography–quadrupole/time of flight-mass spectrometry

(2012) Ling Yi et al.   JOURNAL OF CHROMATOGRAPHY A

Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β2AR agonist identification in alkaloidal extract of Alstonia scholaris

(2012) Yuanyuan Hou et al.   JOURNAL OF CHROMATOGRAPHY A

Identification of a Novel Family of BRAFV600E Inhibitors

(2012) Jie Qin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients

(2011) Roberto Ciarcia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High throughput identification of components from traditional Chinese medicine herbs by utilizing graphene or graphene oxide as MALDI-TOF-MS matrix

(2011) Yang Liu et al.   JOURNAL OF MASS SPECTROMETRY

Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats

(2010) D Peter et al.   BRITISH JOURNAL OF PHARMACOLOGY

The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical action

(2010) Erik H.F. Wong et al.   PHARMACOLOGY & THERAPEUTICS

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-β1-stimulated fibroblasts

(2009) Shinsaku Togo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of higenamine in Radix AconitiLateralis Preparataas a beta2-adrenergic receptor agonist1

(2008) Gang BAI et al.   ACTA PHARMACOLOGICA SINICA

Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats

(2008) Hua Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine

(2008) Feng Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory and analgesic effects and molecular mechanisms of JCICM-6, a purified extract derived from an anti-arthritic Chinese herbal formula

(2008) Y.F. Wong et al.   PHYTOMEDICINE

Sinomenine Versus NSAIDs for the Treatment of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

(2008) Min Xu et al.   PLANTA MEDICA

Morphinane Alkaloid Dimers fromSinomenium acutum

(2007) Hui-Zi Jin et al.   JOURNAL OF NATURAL PRODUCTS