Article
Plant Sciences
Yuhan Jiao, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Jingjing Jiang, Xiuqin Jia
Summary: The study found that Polyphyllin II can inhibit proliferation and induce apoptosis in non-small cell lung cancer cells. It also induces autophagy, and there is a relationship between autophagy and apoptosis. Inhibiting autophagy may enhance the apoptotic effect and exert anticancer activity.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Immunology
Genshen Zhong, Jiaojiao Zhang, Ying Guo, Yichun Wang, Minna Wu, Jie Ren, Yuan Li, Xiaoying Zhang, Beiyan Zhou, Weidong Zhao, Yunwei Lou, Hui Wang, Jianping Ye
Summary: The study demonstrates that IF1 gene knockout protects mice from IBD, showing reduced inflammation, preserved intestinal barrier integrity, and decreased neutrophil number and activity. IF1 may contribute to IBD pathogenesis by promoting neutrophil autophagy, and its attenuation leads to resistance to IBD in knockout mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Carolina Maschietto Pucinelli, Ricardo B. Lima, Lana K. Y. Almeida, Marilia P. Lucisano, Amily Z. Cordoba, Julie T. Marchesan, Lea A. B. da Silva, Raquel A. B. da Silva
Summary: This study aimed to evaluate the expression of IFI16 and IFN-alpha/beta receptors during the genesis and development of experimental apical periodontitis in mice teeth. The results showed that IFI16 protein expression was highest during the early periods after apical periodontitis induction, while IFN-alpha/beta receptor expression was highest after the disease became established.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Milica Kosic, Verica Paunovic, Biljana Ristic, Aleksandar Mircic, Mihajlo Bosnjak, Danijela Stevanovic, Tamara Kravic-Stevovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Summary: The study showed that 3-methyladenine (3MA) can prevent cancer cell death induced by energy stress through autophagy-independent mechanisms, possibly involving JNK suppression and decrease of oxidative stress. It highlights the need for caution when using 3MA as an autophagy inhibitor.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ines M. Aparicio, Patricia Rojo-Dominguez, Alba Castillejo-Rufo, Fernando J. Pena, Jose A. Tapia
Summary: This study aimed to investigate the role of autophagy in stallion spermatozoa during capacitation and acrosome reaction. The activation of autophagy components, such as LC3, was observed in spermatozoa during these processes. Furthermore, the inhibition or activation of autophagy-related pathways affected the acrosome reaction. These findings suggest that noncanonical autophagy may facilitate the acrosome reaction in stallion sperm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Education, Scientific Disciplines
Jasleen Kaur Virdi, Ritu Kulshrestha, Amteshwar Singh Jaggi
Summary: Administration of 3-nitropropionic acid led to motor and cognitive decline in animals, along with neuronal injury and loss in the striatal region. Treatment with 3-methyladenine and chloroquine ameliorated these symptoms, possibly through involvement of autophagy. Treatment with these pharmacological agents may improve Huntington's disease symptoms by inhibiting 3-nitropropionic acid-induced neurodegeneration.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Article
Immunology
Keren Ni, Yongmei Hua
Summary: The study showed that GYY4137 has proinflammatory effects and promotes autophagy in periodontitis, and the induced autophagy may function as a cytoprotective mechanism to prevent excessive inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Gyusang Jeong, Seung Hyun Shin, Su Na Kim, Yongjoo Na, Byung Cheol Park, Jeong Hun Cho, Won-Seok Park, Hyoung-June Kim
Summary: Inhibiting autophagy can accelerate the spontaneous decomposition of human dermal papilla cells and reduce hair loss. Additionally, components of Panax ginseng extract can enhance autophagy in dermal papilla cells.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Cell Biology
Anthony N. Patrizz, Jose F. Moruno-Manchon, Lena M. O'Keefe, Sarah J. Doran, Anita R. Patel, Venugopal R. Venna, Andrey S. Tsvetkov, Jun Li, Louise D. McCullough
Summary: The study revealed differences in autophagy between sexes after ischemic stroke, with inhibition of autophagy reducing infarct volume in males and ovariectomized females but increasing infarct size in females and ovariectomized females supplemented with estrogen. Male neurons showed increased autophagy markers under stress conditions compared to female neurons, and E2 supplementation inhibited autophagy in male neurons while benefiting cell survival in female neurons. Autophagy regulators have different effects in a sex-dependent manner in neurons post-ischemic stroke.
Article
Cell Biology
Lucy Y. Tao, Katarzyna B. Lagosz-Cwik, Jolanda M. A. Hogervorst, Ton Schoenmaker, Aleksander M. Grabiec, Tim Forouzanfar, Fridus A. van der Weijden, Teun J. de Vries
Summary: Research suggests that metformin has beneficial effects on the periodontal status of periodontitis patients by inhibiting osteoclast formation and activity, potentially benefiting the bone as a whole.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Zhanqi Wang, Xuan Feng, Guorui Zhang, Haiyun Li, Feng Zhou, Yaxin Xie, Tianjiao Li, Chengzhi Zhao, Wenxin Luo, Yi Xiong, Yingying Wu
Summary: ART treatment effectively ameliorated ligature-induced periodontitis by attenuating osteoclast formation through blocking NLRP3 inflammasome activation and enhancing osteogenic differentiation by alleviating cytokine expression. These findings provide a new perspective on the mechanism of ART treatment for periodontitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ahmed I. Ashmawy, Hanan S. El-Abhar, Dalaal M. Abdallah, Mennatallah A. Ali
Summary: The phytochemical sulforaphane (SFN) has potential anti-obesity effects by reducing weight gain, blood glucose, and serum leptin levels, improving lipid profile, inhibiting lipogenesis-related enzymes, and regulating inflammatory pathways and autophagy. The combination of SFN with the antimalarial drug chloroquine (CQ) enhances the anti-obesity effects of SFN.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ryan C. Russell, Kun-Liang Guan
Summary: Autophagy is a cellular degradation pathway that plays a crucial role in maintaining cellular homeostasis. It can both suppress tumorigenesis and promote cancer development. This article summarizes the effects of autophagy on cancer initiation, progression, immune infiltration, and metabolism, as well as discussing the efforts to target autophagy pharmacologically and future research directions.
Article
Biochemistry & Molecular Biology
Fumitaka Hiura, Yuko Kawabata, Tsukasa Aoki, Akiko Mizokami, Eijiro Jimi
Summary: The study reveals the importance of ATG4/LC3 in osteoclast maturation and bone resorption. By using a specific inhibitor of ATG4B, NSC185058 (NSC), osteoclastogenesis and maturation can be inhibited, leading to a decrease in alveolar bone resorption in a periodontitis model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Fangfang Zhao, Guohe Feng, Junyao Zhu, Zhijun Su, Ruyi Guo, Jiangfu Liu, Huatang Zhang, Yongzhen Zhai
Summary: The study demonstrates that the autophagy inhibitor 3-MA can alleviate acquired drug resistance of sorafenib by suppressing autophagy activity, enhancing sensitivity to advanced hepatocellular carcinoma therapy.
Article
Dentistry, Oral Surgery & Medicine
J. Qian, J. Lu, Y. Huang, M. Wang, B. Chen, J. Bao, L. Wang, D. Cui, B. Luo, F. Yan
Summary: The study investigated the impact and mechanisms of periodontitis salivary microbiota on colonic inflammation. Results showed that in the periodontitis colitis model, salivary microbiota exacerbated colitis, resembling the pathology of ulcerative colitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dan Qiao, Rixin Chen, Lingjun Li, Feng Zhu, Yangheng Zhang, Fuhua Yan
Summary: Accelerated alveolar bone loss (ABL) spontaneously occurred in an IL-10 knockout mouse model of inflammatory bowel disease (IBD) and was more correlated with intestinal inflammation. Immunopathological changes may be the potential cause of abnormal alveolar bone metabolism.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mengyun Zhang, Ying Liao, Xin Tong, Fuhua Yan
Summary: In this study, a novel urea derivative was encapsulated in PLGA nanoparticles and showed satisfying physicochemical characteristics. The drug-loaded nanoparticles exhibited negligible cytotoxicity against human oral squamous cell carcinoma cells and significantly inhibited the growth and lactic acid production of S. mutans.
Article
Dentistry, Oral Surgery & Medicine
Lili Li, Min Wang, Jun Bao, Nannan Wang, Yuezhen Huang, Shasha He, Bin Chen, Fuhua Yan
Summary: This study found that periodontitis may impact systemic bone homeostasis through regulation of gut microbiota, indicating the importance of periodontitis in bone health.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jun Bao, Lili Li, Yangheng Zhang, Min Wang, Faming Chen, Shaohua Ge, Bin Chen, Fuhua Yan
Summary: This study aimed to investigate whether periodontitis induces dysbiosis of gut microbiota through invasion by salivary microbes. The results showed significant differences in both the faecal and salivary microbiota between periodontally healthy participants and patients with severe periodontitis. Furthermore, transplantation of salivary microbes into mice revealed significant differences in the composition of the gut microbiota and alterations in intestinal health-related markers. In addition, salivary microbes were found to persist in the gut for at least 24 hours.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan
Summary: Periodontitis-related salivary microbiota may exacerbate the pathogenesis of Alzheimer's disease through the gut-brain axis. In this study, the gavage of periodontitis-related salivary microbiota in APP(swe)/PS1(Delta E9) transgenic mice impaired cognitive function, increased beta-amyloid accumulation and neuroinflammation, along with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation.
Article
Dentistry, Oral Surgery & Medicine
Bin Chen, Songying Li, Yaqin Chang, Jiading Zhang, Jiaying Liu, Yingchun Dong, Fuhua Yan
Summary: The aim of this study was to determine the role of macrophages in different stages of periodontal healing. The results showed that M2 macrophages play an important role in the middle and late stages of tissue healing and can promote the proliferation of MSCs. It is suggested that interventions targeting M2 macrophages should be considered during tissue proliferation phase in future periodontal regenerative therapy.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xihong Zou, Chaoyi Liu, Xudong Wu, Zhiyao Yuan, Fuhua Yan
Summary: This study investigated the changes in the m6A methylation modification profile of human periodontal ligament cells (hPDLCs) in response to inflammatory conditions. The results showed that inflammation inhibited the osteogenic differentiation of hPDLCs and affected their m6A methylation profile. Rating: 8/10.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Engineering, Biomedical
Dan Qiao, Shuyu Cheng, Zhen Xing, Qian Zhang, Shiyuan Song, Fuhua Yan, Yangheng Zhang
Summary: A study designed and prepared MR-targeted glycosylated nano-hydroxyapatites (GHANPs) to reprogram macrophages into polarized M2s, promoting bone regeneration. The GHANPs induced macrophage M2 polarization and enhanced osteoblastic differentiation of stem cells. Mechanistic studies suggested that GHANPs might influence macrophage polarization through modulating cell metabolism. In vivo experiments using a rat cranial defect model demonstrated that GHANPs promoted bone regeneration and increased the ratio of M2/M1 macrophages during early bone repair. This study indicates the promising potential of the MR-targeted macrophage M2 polarization strategy in endogenous bone regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuying Wu, Yu Qiu, Yuxuan Wu, Qingrong Deng, Yiming Yu, Han Yang, Qiansi Chen, Baochang He, Fuhua Yan, Yanfen Li, Fa Chen
Summary: This study found a significant positive association between certain plasma TFAs and chronic periodontitis, especially among overweight/obese populations. These findings provide new insights into periodontitis prevention from a dietary perspective.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Wang, Lili Li, Jun Qian, Nannan Wang, Jun Bao, Jiangyue Lu, Faming Chen, Yanfen Li, Yangheng Zhang, Fuhua Yan
Summary: In this study, the salivary microbiota from patients with periodontitis was transferred to obese mice induced by high-fat diet to investigate the influence on gut microbiome and liver metabolism. The results showed that periodontitis salivary microbiota altered gut microbiota composition and exacerbated intestinal barrier dysfunction, leading to activation of toll-like receptor 4 signaling and release of pro-inflammatory factors in the liver. Moreover, the upregulation of the tryptophan-kynurenine-AhR signal axis in the liver was associated with aggravated hepatic steatosis and dysregulation of glucolipid metabolism during NAFLD development. This study suggests that periodontitis salivary microbiota may worsen the pathological progression of NAFLD in the context of obesity, with the tryptophan-AhR pathway potentially playing a key role.
Article
Dentistry, Oral Surgery & Medicine
Yuying Wu, Baochang He, Qiansi Chen, Rong Yu, Yuxuan Wu, Han Yang, Yiming Yu, Fuhua Yan, Yanfen Li, Fa Chen
Summary: This study found a significant negative association between adherence to the Mediterranean diet and periodontitis, with obesity indicators mediating this association.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Qiansi Chen, Ruiyang Ge, Yuxuan Wu, Yuying Wu, Han Yang, Yiming Yu, Qingrong Deng, Yu Qiu, Baochang He, Fuhua Yan, Yanfen Li, Fa Chen
Summary: This study found a positive association between coffee intake (especially certain types of coffee) and caffeine metabolites (1-MU, 1,3-DMU, 3,7-DMU, 1,7-DMX, and AAMU) with periodontitis and its severity.
JOURNAL OF PERIODONTOLOGY
(2023)