Article
Obstetrics & Gynecology
Edgardo Somigliana, Andrea Busnelli, Erkan Kalafat, Paola Vigano, Baris Ata
Summary: Most proposed definitions of recurrent implantation failure (RIF) are not statistically based. Recently, statistical approaches have been proposed, but their effectiveness relies on endorsement from the scientific community.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Paul Pirtea, Marcelle I. Cedars, Kate Devine, Baris Ata, Jason Franasiak, Catherine Racowsky, Jim Toner, Richard T. Scott, Dominique de Ziegler, Kurt T. Barnhart
Summary: To date, there is no clear definition and function impairment of recurrent implantation failure (RIF). Therefore, the term RIF is currently used somewhat haphazardly based on clinicians' judgment. International experts in reproductive medicine met in Lugano, Switzerland, in July 2022 to review RIF and determine its diagnosis and management. Rating: 8/10
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Fang Yuan, Jingjing Fan, Tiantain Cheng, Huanhuan Xie, Qiaohua He
Summary: This study demonstrates that the number of previous embryo implantation failures is an independent factor that affects the implantation rate, clinical pregnancy rate, spontaneous abortion rate, and live birth rate of patients undergoing IVF/ICSI-ET. As the number of previous embryo implantation failures increases, the implantation rate, clinical pregnancy rate, and live birth rate of IVF/ICSI-ET patients significantly decrease, while the rate of early spontaneous abortion gradually increases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Fangyuan Li, Ruihui Lu, Cheng Zeng, Xin Li, Qing Xue
Summary: This study developed a predictive model to estimate the individual probability of clinical pregnancy failure for poor ovarian responders (PORs) undergoing IVF/ICSI. The model was constructed based on characteristics associated with pregnancy failure, and showed satisfactory performance in both the training and validation groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
N. Sung, S. A. Khan, M. E. Yiu, G. Jubiz, M. D. Salazar, A. Skariah, S. Dambaeva, J. Kwak-Kim
Summary: This study found that immunomodulatory and anticoagulation treatment significantly improved IVF success rates and live birth rates for women with immune etiologies of recurrent pregnancy losses and implantation failures, suggesting the potential benefits of this therapeutic approach for reproductive outcomes in such patients.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada
Summary: The aim of this study was to evaluate the association between chronic endometritis and uterine endometrium microbiota with repeated implantation failures and recurrent pregnancy losses. The results suggest that chronic endometritis may be involved in the pathophysiology of recurrent pregnancy losses and repeated implantation failures. Lactobacillus iners and Ureaplasma species may be associated with the etiology of chronic endometritis.
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai, Jie Huang, Jiayin Liu, Yundong Mao
Summary: Endometriosis activity has a negative impact on the outcomes of IVF/ICSI cycles in patients with recurrent implantation failure (RIF). Patients with controlled endometriosis activity showed higher cumulative live birth rates, emphasizing the importance of medical treatment for improved prognosis in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Karolina Piekarska, Pawel Radwan, Agnieszka Tarnowska, Andrzej Wisniewski, Michal Radwan, Jacek R. Wilczynski, Andrzej Malinowski, Izabela Nowak
Summary: During early pregnancy, maternal uterine natural killer (NK) cells play a key role in regulating the immune response, with ERAP1 and ERAP2 influencing the HLA class I immunopeptidome formation. This study explores the associations between ERAP1 and ERAP2 polymorphisms, KIR, and HLA-C genes in recurrent implantation failure (RIF), revealing potential impacts of certain ERAP polymorphisms on RIF susceptibility in HLA-C2-positive patients. Moreover, differences in ERAP secretion levels between fertile women and those experiencing IVF procedures suggest potential implications of ERAP1 and ERAP2 in reproductive processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
D. Cimadomo, M. J. de los Santos, G. Griesinger, G. Lainas, N. Le Clef, D. J. McLernon, D. Montjean, B. Toth, N. Vermeulen, N. Macklon
Summary: This article provides the first ESHRE good practice recommendations for defining and managing recurrent implantation failure (RIF) in patients undergoing ART. RIF is a challenge in the ART clinic, with numerous investigations and interventions offered and applied without clear biological rationale or evidence of benefit. The recommendations include investigating causes and contributing factors of RIF, as well as improving the chances of a successful pregnancy.
HUMAN REPRODUCTION OPEN
(2023)
Article
Endocrinology & Metabolism
Violeta Fodina, Alesja Dudorova, Juris Erenpreiss
Summary: The study found that testing for embryo aneuploidy using the PGT-A method can improve clinical outcomes in ICSI cycles for patients with RIF, while the ability of the ERA test to improve clinical outcomes seems to be rather limited.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Cell Biology
Sofia Makieva, Celine Staehli, Min Xie, Ana Velasco Gil, Maike Katja Sachs, Brigitte Leeners
Summary: This study aimed to determine the association between the time interval from insemination to vitrification and pregnancy rate. The findings suggest that the latest timing of vitrification is significantly associated with a higher pregnancy rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Pantos, Sokratis Grigoriadis, Evangelos Maziotis, Kalliopi Pistola, Paraskevi Xystra, Agni Pantou, Georgia Kokkali, Athanasios Pappas, Maria Lambropoulou, Konstantinos Sfakianoudis, Mara Simopoulou
Summary: Recurrent implantation failure (RIF) is a complex condition affecting 10-15% of IVF couples. Dysregulation of interleukins (ILs), which are involved in immune responses, plays a crucial role in the pathogenesis of RIF. Further research is needed to understand the molecular mechanisms of ILs in order to provide evidence-based consultancy and decision making for RIF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Marina Jarne-Borras, Francesc Miro-Mur, Ariadna Anunciacion-Llunell, Jaume Alijotas-Reig
Summary: Through a systematic review and meta-analysis, we found that different types of antiphospholipid antibodies are present in women with recurrent implantation failure. Among them, IgG anticardiolipin autoantibodies are associated with recurrent implantation failure. Additionally, anti-beta 2 glycoprotein I-IgA, antiphosphatidylglycerol-IgG, and antiphosphatidylglycerol-IgM are also associated with recurrent implantation failure.
AUTOIMMUNITY REVIEWS
(2022)
Review
Immunology
Huijun Chen, Xiaoli Zhang, Ge Lin, Fei Gong, Berthold Hocher
Summary: COVID-19 vaccination has potential effects on reproductive health in women undergoing assisted reproductive techniques. A study on 536 women undergoing IVF/ICSI treatment in China showed that COVID-19 vaccination may impair oocyte maturation, fertilization rate, and other reproductive outcomes. A systematic review of existing studies found that mRNA vaccines have no adverse effects on reproductive outcomes, while inactivated vaccines may affect oocyte maturation and fertilization rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Yizhen Liu, Jim G. Thornton, Wentao Li, Madelon van Wely, Ben W. Mol
Summary: The analysis of 22 RCTs by Dr. Maged suggests potential data integrity issues, and it is recommended that journals investigate according to the guidelines of the Committee on Publication Ethics. The procedures demonstrated in this paper may help assess data integrity for future attempts to verify the authenticity of published RCTs.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Jennifer A. Wessel, Sarah Hunt, Madelon van Wely, Femke Mol, Rui Wang
Summary: This article reviews the concerns and considerations surrounding the overuse of in vitro fertilization (IVF), as well as the underappreciation of alternatives to IVF in clinical practice and research. It summarizes the current evidence on the effectiveness, safety, and cost-effectiveness of various alternatives to IVF, such as expectant management, intrauterine insemination, tubal flushing, in vitro maturation, and intravaginal culture. The article also discusses the trend of IVF use over the last decade and the roles of different alternatives to IVF in modern reproductive medicine.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Krystle Y. Chong, Sarah Solangon, Kurt Barnhart, Pamela Causa-Andrieu, Perrine Capmas, George Condous, Liesl de Waard, James M. N. Duffy, Andrew W. Horne, Maria Memtsa, Femke Mol, Munira Oza, Romina Pesce, Annika Strandell, Madelon van Wely, Janneke van't Hooft, Lan N. Vuong, Jian Zhang, Davor Jurkovic, Ben W. Mol
Summary: This study developed a core outcome set for ectopic pregnancy (EP) to address methodological deficiencies in published randomized controlled trials and systematic reviews. The core outcome set consists of 6 outcomes, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
E. M. Bordewijk, T. Jannink, N. S. Weiss, T. de Vries, M. Nahuis, A. Hoek, M. Goddijn, B. W. Mol, M. van Wely, M-Ovin Study Grp
Summary: This study aimed to investigate the long-term outcomes of using gonadotrophins versus clomiphene citrate (CC) in women with normogonadotropic anovulation and clomiphene failure. The results showed that about four in five women were able to have a live birth after experiencing clomiphene failure, with no significant difference in pregnancy outcomes among the allocated groups.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Sarah Annie Solangon, Madelon Van Wely, Norah Van Mello, Ben W. Mol, Jackie A. Ross, Davor Jurkovic
Summary: Ectopic pregnancy is a common health condition affecting 1 in 100 women. Methotrexate (MTX) and expectant management are both viable treatment options for women with mild symptoms and low hCG levels. A systematic review and meta-analysis of randomized controlled trials showed no statistically significant difference in treatment efficacy between MTX and expectant management, suggesting that initial expectant management may be preferred due to fewer side-effects.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Noor E. Simons, Annemijn A. de Ruigh, Janneke van't Hooft, Cornelieke S. H. Aarnoudse-Moens, Madelon van Wely, David P. van der Ham, Augustinus S. P. van Teeffelen, Tessa J. Roseboom, Ben W. Mol, Aleid G. Leemhuis, Eva Pajkrt
Summary: Management of late preterm prelabor rupture of membranes between 34+0 and 36+6 weeks' gestation shows similar risks between induction of labor and expectant management. However, children at 2 years of age show more neurodevelopmental delay with expectant management. Long-term outcomes in child development after 2 years are still unknown.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Joanne Aalberts, Madelon van Wely
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
T. R. Zaat, E. B. Kostova, P. Korsen, M. G. Showell, F. Mol, M. van Wely
Summary: Based on a systematic review and meta-analysis, natural cycle frozen embryo transfer (NC-FET) appears to be associated with a lower risk of adverse obstetric and neonatal outcomes compared to artificial cycle frozen embryo transfer (AC-FET). Furthermore, NC-FET with luteal phase support (LPS) may reduce the risk of preterm birth. Therefore, NC-FET should be the preferred treatment for women undergoing frozen embryo transfer. The use of LPS in NC-FET may decrease the risk of preterm birth, but more research is needed to determine its efficacy and safety.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Medicine, General & Internal
D. C. Kieslinger, C. G. Vergouw, L. Ramos, B. Arends, M. hj m Curfs, E. Slappendel, E. H. Kostelijk, M. H. E. C. Pieters, D. Consten, M. O. Verhoeven, D. E. Besselink, F. Broekmans, B. J. Cohlen, J. M. J. Smeenk, S. Mastenbroek, C. H. de Koning, Y. M. van Kasteren, E. Moll, J. van Disseldorp, E. A. Brinkhuis, Ea m Kuijper, W. M. van Baal, H. G. van Weering, P. J. Q. van der Linden, M. H. Gerards, P. M. Bossuyt, M. van Wely, C. B. Lambalk
Summary: Time-lapse monitoring does not improve clinical outcomes compared with routine methods, casting doubts on its widespread application in fertility treatments.
Article
Obstetrics & Gynecology
Jitske Eliveld, Ilias van der Bles, Madelon van Wely, Andreas Meissner, Alexandre T. Soufan, Annemieke C. Heijboer, Sjoerd Repping, Fulco van der Veen, Ans M. M. van Pelt
Summary: This study investigates the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE). The results show that 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia, and 3% of men with NOA required testosterone replacement therapy (TRT). Klinefelter syndrome is strongly associated with the need for TRT, while no association is found for obstructive azoospermia or NOA. Additionally, higher testosterone concentrations before TESE are linked to a lower chance of needing TRT.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Aafke Bruinsma, Judit K. J. Keulen, Rik Van Eekelen, Madelon Van Wely, Joep C. Kortekaas, Jeroen Van Dillen, Joris A. M. Van de Post, Ben W. Mol, Esteriek de Miranda
Summary: This study assessed the cost-effectiveness of elective induction of labour (IOL) at 41 weeks compared to expectant management (EM) until 42 weeks for late-term pregnancies. The results showed that IOL has an 80% chance of being cost-effective for preventing adverse perinatal outcomes at a certain willingness-to-pay threshold. Subgroup analysis suggested that IOL may be cost-effective for nulliparous women, but unlikely to be cost-effective for multiparous women. The cost-effectiveness in other settings will depend on the baseline characteristics of the population and the organization and funding of the healthcare system.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X
(2023)
Editorial Material
Obstetrics & Gynecology
Madelon van Wely
Summary: Miscarriage is a common occurrence that has a profound psychological impact on individuals and couples. This article provides an overview of sporadic and recurrent miscarriage, discussing their prevalence, psychological impact, genetics, the potential role of uterine natural killer cells, association with infections, and possible interventions.
FERTILITY AND STERILITY
(2023)
Letter
Obstetrics & Gynecology
T. R. Zaat, F. Mol, M. van Wely
HUMAN REPRODUCTION UPDATE
(2023)
Editorial Material
Obstetrics & Gynecology
Madelon van Wely, Julie M. Hastings, Basil Tarlatzis, Arne Sunde
HUMAN REPRODUCTION UPDATE
(2023)
Review
Obstetrics & Gynecology
Janneke A. C. van Baar, Elena B. Kostova, John Allotey, Shakila Thangaratinam, Javier R. Zamora, Mercedes Bonet, Caron Rahn Kim, Lynne M. Mofenson, Heinke Kunst, Asma Khalil, Elisabeth van Leeuwen, Julia Keijzer, Marije Strikwerda, Bethany Clark, Maxime Verschuuren, Arri Coomarasamy, Mariette Goddijn, Madelon van Wely
Summary: This systematic review aims to determine the prevalence of early pregnancy loss in women with SARS-Cov-2 infection and compare the risk to pregnant women without SARS-CoV-2 infection.
HUMAN REPRODUCTION UPDATE
(2023)