Article
Gastroenterology & Hepatology
Allon Kahn, Julia Crook, Michael G. Heckman, Mikolaj A. Wieczorek, Sarmed Sami, Diana Snyder, Siddharth Agarwal, Jose Santiago, Jacobo Ortiz Fernandez-Sordo, W. Keith Tan, Ramona Lansing, Kenneth K. Wang, Krish Ragunath, Massimiliano DiPietro, Herbert Wolfsen, Francisco Ramirez, David Fleischer, Cadman L. Leggett, Prasad G. Iyer
Summary: This study proposes optimal surveillance intervals after complete eradication of intestinal metaplasia (CE-IM) based on a multicenter international cohort, aiming to reduce the endoscopic burden for patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
Arvind J. Trindade, Jianying Zhang, Kara L. Raphael, Jiejing Qiu, John Hauschild, Petros C. Benias
Summary: This retrospective observational study examined the utilization of endoscopic ablation therapy and esophagectomy in patients with Barrett's esophagus. The study found an increasing trend in the utilization of ablation therapy, while esophagectomy showed a decreasing trend. These findings suggest that endoscopic ablation therapy has become the predominant method of treatment for Barrett's esophagus with dysplasia.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Chetan Mittal, V. Raman Muthusamy, Amit Rastogi, Vladimir Kushnir, Mariah Wood, Sachin Wani, Srinadh Komanduri
Summary: This study aimed to assess the rate of visible lesion (VL) detection by academic and community endoscopists using high-definition white-light endoscopy (HD-WLE) and narrow-band imaging (NBI). Participants identified VLs using HD-WLE and NBI, and the results showed that 28% and 31% of VLs were not identified using HD-WLE and NBI respectively. The study also found that the rate of VL detection was associated with the endoscopist's experience and the number of surveillance endoscopies performed each month.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Robert D. Odze, John Goldblum, Vivek Kaul
Summary: Barrett's esophagus (BE) is a premalignant condition that can be effectively monitored and managed using the Wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS(3D)) technique, which has shown to significantly increase detection rates of dysplasia and intestinal metaplasia in BE patients.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Noam Peleg, Jacob E. Ollech, Steven Shamah, Boris Sapoznikov
Summary: This study compared the effectiveness of advanced imaging and the Seattle protocol (SP) in detecting dysplasia in patients with Barrett's esophagus (BE). The results showed that SP is significant in the detection of low-grade and high-grade dysplasia, and should remain the main method for endoscopic surveillance in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jennifer M. Kolb, Mindy Chen, Anna Tavakkoli, Jazmyne Gallegos, Jack O'Hara, Wyatt Tarter, Camille J. Hochheimer, Bryan Golubski, Noa Kopplin, Lilly Hennessey, Anita Kalluri, Shalika Devireddy, Frank I. Scott, Gary W. Falk, Amit G. Singal, Ravy K. Vajravelu, Sachin Wani
Summary: Most EAC patients do not have a previous BE diagnosis, indicating a failure of current screening practices. Understanding patient attitudes and barriers is crucial for improving BE screening adherence.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsin-Yu Fang, Stefan Stangl, Sabrina Marcazzan, Marcos J. Braz Carvalho, Theresa Baumeister, Akanksha Anand, Julia Strangmann, Julia Slotta Huspenina, Timothy C. Wang, Roland M. Schmid, Marcus Feith, Helmut Friess, Vasilis Ntziachristos, Gabriele Multhoff, Dimitris Gorpas, Michael Quante
Summary: This study evaluated the use of a highly specific Hsp70-specific contrast agent in guided fluorescence molecular endoscopy biopsy, showing promising potential to improve tumor surveillance in BE patients, especially in cases with dysplasia and EAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Dale J. Waterhouse, Wladyslaw Januszewicz, Sharib Ali, Rebecca C. Fitzgerald, Massimiliano di Pietro, Sarah E. Bohndiek
Summary: The study demonstrates the potential of spectral endoscopy technology to improve detection efficiency of Barrett's esophagus, and the ability to accurately classify disease stages using deep learning, enhancing the contrast of endoscopic examination.
Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Samuel Jesus Martinez-Dominguez, Angel Lanas, Maria Jose Domper-Arnal
Summary: The main clinical relevance of Barrett's esophagus is its potential progression to esophageal adenocarcinoma. Screening is not recommended for the general population, but surveillance is needed after diagnosis of BE. The gold standard for diagnosis and surveillance is high-definition oral endoscopy with random biopsies. Visible lesions should be completely resected, and in the absence of visible lesions, radiofrequency ablation should be performed.
Article
Gastroenterology & Hepatology
Carlijn A. M. Roumans, Ruben D. van der Bogt, Daan Nieboer, Ewout W. Steyerberg, Dimitris Rizopoulos, Iris Lansdorp-Vogelaar, Katharina Biermann, Marco J. Bruno, Manon C. W. Spaander
Summary: In this multicenter prospective cohort study, it was found that half of Barrett's esophagus (BE) surveillance endoscopies do not adhere to guideline recommendations. However, there was no clear association between nonadherence and endoscopic curability of esophageal adenocarcinoma (EAC) or mortality, indicating the need for optimization of BE surveillance guidelines to minimize the burden of endoscopies.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Gastroenterology & Hepatology
Jennifer M. Kolb, Christian Davis, J. Lucas Williams, Jennifer Holub, Nicholas Shaheen, Sachin Wani
Summary: This study evaluated adherence rates to quality indicators (QIs) in Barrett's esophagus (BE), including the Seattle protocol and surveillance interval recommendations, and found significant variability among endoscopists and sites. These population-based results from the US can serve as a benchmark for quality improvement initiatives and intervention trials aimed at improving outcomes for patients with BE.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Mark Redston, Amy Noffsinger, Anthony Kim, Fahire G. Akarca, Marianne Rara, Diane Stapleton, Laurel Nowden, Richard Lash, Adam J. Bass, Matthew D. Stachler
Summary: This study developed a reliable criteria for grading abnormal p53 immunohistochemical expression and tested its utility as a biomarker for progression in Barrett's esophagus (BE). The findings showed that abnormal p53 expression was strongly associated with neoplastic progression in BE, regardless of histologic diagnosis and could predict progression among nondysplastic BE, indefinite for dysplasia, and low-grade dysplasia.
Review
Gastroenterology & Hepatology
Nour Hamade, Amrit K. Kamboj, Rajesh Krishnamoorthi, Siddharth Singh, Leslie C. Hassett, David A. Katzka, Charles J. Kahi, Hala Fatima, Prasad G. Iyer
Summary: Through analysis of multiple studies, a statistically significant inverse correlation was found between neoplasia detection rate and post-endoscopy Barrett's neoplasia, indicating that with an increase in neoplasia detection rate, post-endoscopy Barrett's neoplasia decreases. Further studies are needed to validate this correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
