Value of cerebrospinal fluid α-synuclein species as biomarker in Parkinson's diagnosis and prognosis

CSF α-Synuclein Does Not Discriminate Dementia with Lewy Bodies from Alzheimer's Disease

(2017) Fransje E. Reesink et al.   JOURNAL OF ALZHEIMERS DISEASE

New clinical trials for nonmotor manifestations of Parkinson's disease

(2015) Anette Schrag et al.   MOVEMENT DISORDERS

Correlation between decreased CSF α-synuclein and Aβ1–42 in Parkinson disease

(2015) Chandana Buddhala et al.   NEUROBIOLOGY OF AGING

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative

(2015) Brice Laurens et al.   NEUROBIOLOGY OF DISEASE

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Parkinson disease with REM sleep behavior disorder: Features,  -synuclein, and inflammation

(2015) Y. Hu et al.   NEUROLOGY

Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity

(2015) Tessandra Stewart et al.   Acta Neuropathologica Communications

Cerebrospinal Fluid α-Synuclein Predicts Cognitive Decline in Parkinson Disease Progression in the DATATOP Cohort

(2014) Tessandra Stewart et al.   AMERICAN JOURNAL OF PATHOLOGY

Genomic and Pharmacogenomic Biomarkers of Parkinson’s Disease

(2014) Hortensia Alonso-Navarro et al.   CURRENT DRUG METABOLISM

Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis

(2014) Liang Gao et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson’s disease

(2014) Yaroslau Compta et al.   JOURNAL OF NEUROLOGY

Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease

(2014) Lucilla Parnetti et al.   MOVEMENT DISORDERS

Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: Evidence from a meta-analysis

(2014) Wataru Sako et al.   MOVEMENT DISORDERS

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

(2014) Alberto Lleó et al.   Nature Reviews Neurology

CSF biomarkers and clinical progression of Parkinson disease

(2014) S. Hall et al.   NEUROLOGY

CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders

(2014) Stefania Mondello et al.   PARKINSONISM & RELATED DISORDERS

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers

(2014) Jan O. Aasly et al.   Frontiers in Aging Neuroscience

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease

(2014) Lucilla Parnetti et al.   Frontiers in Aging Neuroscience

CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease

(2013) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity

(2013) K. D. van Dijk et al.   EUROPEAN JOURNAL OF NEUROLOGY

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

(2013) Therese Fagerqvist et al.   JOURNAL OF NEUROCHEMISTRY

Cerebrospinal fluid biomarkers in Parkinson disease

(2013) Lucilla Parnetti et al.   Nature Reviews Neurology

Quantification of α-synuclein in cerebrospinal fluid: How ideal is this biomarker for Parkinson's disease?

(2013) Brit Mollenhauer   PARKINSONISM & RELATED DISORDERS

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy

(2013) Malin Wennström et al.   PLoS One

Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders

(2012) Sara Hall et al.   ARCHIVES OF NEUROLOGY

Recommendations to standardize preanalytical confounding factors in Alzheimer’s and Parkinson’s disease cerebrospinal fluid biomarkers: an update

(2012) Marta del Campo et al.   Biomarkers in Medicine

Novel One-step Immunoassays to Quantify α-Synuclein

(2012) Michael Bidinosti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease

(2012) Min Jeong Park et al.   Journal of Clinical Neurology

Cerebrospinal fluid α-synuclein levels are elevated in multiple sclerosis and neuromyelitis optica patients during replase

(2012) Honghao Wang et al.   JOURNAL OF NEUROCHEMISTRY

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

(2012) Brit Mollenhauer et al.   NEUROSCIENCE LETTERS

Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease

(2011) Fuyuki Tateno et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias

(2011) Lucilla Parnetti et al.   MOVEMENT DISORDERS

CSF α-synuclein does not differentiate between parkinsonian disorders

(2011) M.B. Aerts et al.   NEUROBIOLOGY OF AGING

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

(2010) Min Shi et al.   ANNALS OF NEUROLOGY

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

(2008) Mariese A. Hely et al.   MOVEMENT DISORDERS

Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?

(2008) Annika Öhrfelt et al.   NEUROSCIENCE LETTERS