Journal
BIOMARKERS
Volume 22, Issue 3-4, Pages 268-278Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1354750X.2016.1204004
Keywords
Biomarker; circulating miR-126; coronary artery disease; microRNAs; type 2 diabetes
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Funding
- College of Medicine and Medical Sciences, Arabian Gulf University, Kingdom of Bahrain [81]
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Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.
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