Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 143, Issue -, Pages 331-340Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2019.08.012
Keywords
Nrf2 activation; Sulforaphane; Aryl hydrocarbon receptor; Ischemia-reperfusion injury; Post-conditioning
Funding
- CONACYT, Mexico [283363, FOSSIS-2016 272256]
Ask authors/readers for more resources
The activation of the transcription factor Nrf2 and the consequent increment in the antioxidant response might be a powerful strategy to contend against reperfusion damage. In this study we compared the effectiveness between sulforaphane (SFN), a well known activator of Nrf2 and the mechanical maneuver of post-conditioning (PostC) to confer cardioprotection in an in vivo cardiac ischemia-reperfusion model. We also evaluated if additional mechanisms, besides Nrf2 activation contribute to cardioprotection. Our results showed that SFN exerts an enhanced protective response as compared to PostC. Bot, strategies preserved cardiac function, decreased infarct size, oxidative stress and inflammation, through common protective pathways; however, the aryl hydrocarbon receptor (AhR) also participated in the protection conferred by SFN. Our data suggest that SFN-mediated cardioprotection involves transient Nrf2 activation, followed by phase I enzymes upregulation at the end of reperfusion, as a long-term protection mechanism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available