Journal
BIOMARKERS
Volume 21, Issue 3, Pages 233-242Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1134660
Keywords
Aristolochic acid nephrotoxicity; biomarker; HK-2; metabolomics; UPLC-MS
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Funding
- National Technology Major Project [2014ZX09304307-001-006]
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Time-course metabolic changes of aristolochic acid nephrotoxicity (AAN) was investigated using acute AAN HK-2 model. And the AAN-related biomarkers were selected. In the results, 11 potential identified biomarkers were selected and validated using multivariate method combined with time-course analysis. Several metabolic pathways, including vitamin metabolism, lipids acalytion, trytophan metabolism and protein degradation were found to be associated with AAN pathology. This research will provide a valuable reference for the discovery of more potential biomarkers of AAN progression in clinic.
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