Journal
BIOMACROMOLECULES
Volume 17, Issue 10, Pages 3153-3161Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.6b00776
Keywords
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Funding
- National Natural Science Foundation of China [21422201, 21372018]
- National Basic Research Program of China (973 Program) [2012CB720600, 2013CB933800]
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A series of Vitamin E (vitE)-labeled PEIs (PEI-vitE(n)) were synthesized and showed excellent complexation ability with plasmid DNA (pDNA). The cellular uptake of PEI-vitE(n)/pDNA-complexes was greatly enhanced with the increase of vitE labeling, which is much better than that of control PEI25 in three different cell lines. PEI-vitE(6) showed the best performance in gfp pDNA delivery and following GFP expression in HEK-293A cells. In addition, in vivo gene delivery in living mice also confirmed that PEI-vitE(6) showed low toxicity and efficiently delivered gfp pDNA to the cells of liver and lung tissues for gene expression.
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