IQGAP1 restrains T‐cell cosignaling mediated by OX40

Eradication of spontaneous malignancy by local immunotherapy

(2018) Idit Sagiv-Barfi et al.   Science Translational Medicine

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

(2017) Manuel A Ferreira et al.   NATURE GENETICS

TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development

(2016) Hiroyuki Nagashima et al.   JOURNAL OF IMMUNOLOGY

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

(2016) Suyong Choi et al.   NATURE CELL BIOLOGY

Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice

(2016) Stefanie N. Linch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OX40, OX40L and Autoimmunity: a Comprehensive Review

(2015) Gwilym J. Webb et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The biology of IQGAP proteins: beyond the cytoskeleton

(2015) A. C. Hedman et al.   EMBO REPORTS

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver

(2013) Chunsheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

(2013) Katherine L Jameson et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The Cytoskeletal Adaptor Protein IQGAP1 Regulates TCR-Mediated Signaling and Filamentous Actin Dynamics

(2012) J. A. Gorman et al.   JOURNAL OF IMMUNOLOGY

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload

(2011) Mauro Sbroggiò et al.   CARDIOVASCULAR RESEARCH

IQGAP1 and its binding proteins control diverse biological functions

(2011) Colin D. White et al.   CELLULAR SIGNALLING

Science gone translational: the OX40 agonist story

(2011) Andrew D. Weinberg et al.   IMMUNOLOGICAL REVIEWS

The IQGAP1 Protein Is a Calmodulin-regulated Barbed End Capper of Actin Filaments

(2011) Andrea Pelikan-Conchaudron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation

(2011) Dean E. McNulty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling

(2011) T. So et al.   JOURNAL OF IMMUNOLOGY

Antigen-independent signalosome of CARMA1, PKC , and TNF receptor-associated factor 2 (TRAF2) determines NF- B signaling in T cells

(2011) T. So et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration

(2010) Norifumi Urao et al.   PLoS One

IQGAP1 regulation and roles in cancer

(2009) Michael Johnson et al.   CELLULAR SIGNALLING

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

(2009) Colin D. White et al.   FEBS LETTERS

The significance of OX40 and OX40L to T-cell biology and immune disease

(2009) Michael Croft et al.   IMMUNOLOGICAL REVIEWS