Article
Biology
Lucia Sanjurjo, Iris A. Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, Kitty C. M. Castricum, Tanja D. De Gruijl, Ulf J. Nilsson, Hakon Leffler, Arjan W. Griffioen, Latifa Elantak, Rory R. Koenen, Victor L. J. L. Thijssen
Summary: The study reveals that specific chemokine-galectin interactions can modulate the immunoregulatory function of galectins, affecting their glycan-binding activity and specificity. In particular, binding of CXCL4 changes the carbohydrate binding site of galectin-1, increasing its apoptotic activity on CD8(+) T cells.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dina B. AbuSamra, Rafael Martinez-Carrasco, Pablo Argueso
Summary: This study reveals the involvement of galectins in regulating surface glycosylation of human monocytes under inflammatory conditions. Galectin-1 negatively influences the expression of galactose epitopes, while galectin-8 and galectin-3 promote their expression.
Article
Cell Biology
Tendai Hunyenyiwa, Kathryn Hendee, Kienna Matus, Priscilla Kyi, Tadanori Mammoto, Akiko Mammoto
Summary: Obesity impairs adipose tissue angiogenesis through modulation of TWIST1-SLIT2 signaling, as demonstrated in endothelial cells isolated from obese humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Anna Ioannidou, Rachel M. Fisher, Carolina E. Hagberg
Summary: The vascular endothelial cells in adipose tissue play a crucial role in regulating nutrient uptake and tissue expansibility, affecting the development and function of adipocytes. Understanding the interplay between endothelial cells, adipocytes, and obesity could lead to new therapeutic approaches for obesity-related pathologies.
Article
Materials Science, Multidisciplinary
Jing Wang, Chunxiang Feng, Yunpeng Zhu, Zhixian Wang, Xiang Ren, Xing Li, Yisheng Ying, Yiqun Tian, Kai Yu, Shiliang Liu, Chang Liu, Xiaoyong Zeng
Summary: Bladder tissue engineering using adipose tissue extract (ATE) shows potential for promoting pluripotent marker proteins in stem cells and enhancing proliferation, migration, and angiogenesis in endothelial cells. The integration of electrospun nanofibers and hyaluronic acid colloidal solution in a patch demonstrates feasibility and effectiveness in repairing bladder defects in a rat model, highlighting its potential for tissue engineering and regenerative medicine.
MATERIALS & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Prakash Gangadaran, Ramya Lakshmi Rajendran, Ji Min Oh, Eun Jung Oh, Chae Moon Hong, Ho Yun Chung, Jaetae Lee, Byeong-Cheol Ahn
Summary: The study found that extracellular vesicles (EVs) derived from stem cells isolated from human adipose tissue contain angiogenic proteins and promote angiogenesis in vitro and in vivo.
Article
Surgery
Dominic Henn, Katharina S. Fischer, Kellen Chen, Autumn H. Greco, Russell A. Martin, Dharshan Sivaraj, Artem A. Trotsyuk, Hai-Quan Mao, Sashank K. Reddy, Ulrich Kneser, Geoffrey C. Gurtner, Volker J. Schmidt, Justin M. Sacks
Summary: This study developed a novel approach for engineering vascularized soft tissue using an injectable nanofiber hydrogel composite enriched with fractionated fat. The results showed that the nanofiber hydrogel composite with fractionated fat maintained its shape without shrinking, had stronger functional vascularization, and promoted macrophage polarization towards regenerative phenotypes compared to the composite alone. This enrichment with fractionated fat represents a promising approach for durable reconstruction of soft-tissue defects.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Adriana Mariel Gentile, Said Lhamyani, Maria Mengual Mesa, Francisco Javier Pavon-Moron, John R. Pearson, Julian Salas, Mercedes Clemente-Postigo, Lucia Perez Costillas, Gabriel Olveira Fuster, Rajaa El Bekay Rizky
Summary: This study aims to determine the miRNA network associated with age-associated angiogenic enrichment in transformed adipose tissue (TAT). The results show that the expression of miR-15b-5p and miR-29a-3p is significantly upregulated in the TAT of elderly patients, along with increased expression of VEGFA and other angiogenic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Vliora, Cosetta Ravelli, Elisabetta Grillo, Michela Corsini, Andreas D. Flouris, Stefania Mitola
Summary: Adipose tissue is an active endocrine organ, which secretes adipokines that have various functions in the body. The plasticity of adipose tissue is associated with angiogenesis, which supports tissue expansion. Abnormal production or loss of certain adipokines can lead to metabolic dysfunction related to obesity. Understanding the role of adipokines in angiogenesis may offer new therapeutic approaches for treating obesity and metabolic diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Engineering, Biomedical
Lu Cui, Yujia Zhao, Yuxuan Zhong, Lanlan Zhang, Xinnan Zhang, Zhenglong Guo, Fanglin Wang, Xin Chen, Hao Tong, Jun Fan
Summary: Adipose tissue engineering using composite hydrogels of DAT, SIS, and Adv shows promising results in promoting angiogenesis and adipogenesis, offering potential clinical applications in soft tissue regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Dominika Zukowska, Aleksandra Gedaj, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski
Summary: FGF/FGFR signaling is important for human body development and homeostasis, and imbalanced FGF/FGFR leads to the progression of severe diseases, such as cancers. Galectins, a type of extracellular carbohydrate-binding proteins, directly interact with the N-glycans of FGFRs and trigger FGFR activation and downstream signaling. Galectin/FGFR signaling has different effects on cell physiology compared to canonical FGF/FGFR units, affecting cell viability and metabolic activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Bruna Caridi, Dilyana Doncheva, Sobha Sivaprasad, Patric Turowski
Summary: Diseases of the retina are significant causes of visual impairment and blindness in developed countries, highlighting the importance of research into their pathogenesis. In addition to vascular endothelial growth factor, galectins may also play an important role in retinal diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Genetics & Heredity
Dong Yu, Ming Bu, Ping Yu, Yaping Li, Yang Chong
Summary: Galectins are a family of proteins that have at least one carbohydrate-recognition domain and play a key role in the wound healing process. They participate in various physiological and pathological reactions such as inflammation, angiogenesis, re-epithelialisation, and fibrous scar formation. Therefore, Galectins have the potential to be used as therapeutic drugs for wounds.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Endocrinology & Metabolism
Giuseppe Petito, Federica Cioffi, Elena Silvestri, Rita De Matteis, Davide Lattanzi, Pieter de Lange, Assunta Lombardi, Maria Moreno, Fernando Goglia, Antonia Lanni, Rosalba Senese
Summary: This study demonstrates that T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation. Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ekta Manocha, Alessandra Consonni, Fulvio Baggi, Emilio Ciusani, Valentina Cocce, Francesca Paino, Carlo Tremolada, Arnaldo Caruso, Giulio Alessandri
Summary: Pericytes, as a type of mesenchymal stromal cells, have a crucial role in tissue regeneration and vascular homeostasis. This study found that CD146(+) pericytes from adipose tissue may have a higher efficacy in promoting angiogenesis and vascular stabilization compared to CD146(-) pericytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura
Summary: This study demonstrates that Gal-3 expression in long-term repopulating HSCs is induced in response to Tie2 and Mpl, and plays a crucial role in maintaining HSC quiescence through regulation of p21.
NATURE COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Agustin L. Lujan, Diego O. Croci, Gabriel A. Rabinovich, Maria T. Damiani
Summary: Sexually transmitted infections (STIs) have a significant impact on women's reproductive and sexual health. Galectins play a vital role in the binding, internalization, and invasion processes of pathogens. By interacting with glycosylated receptors on both pathogens and host cells, galectins act as a bridge between them. Targeting galectins could potentially help prevent or reduce the transmission of STIs and lower treatment costs.
NATURE REVIEWS UROLOGY
(2022)
Article
Cell Biology
M. Constanza Baroni Pietto, Paola R. Lev, Ana C. Glembotsky, Cecilia P. Marin Oyarzun, Graciela Gomez, Victoria Collado, Cecilia Pisoni, Ramiro A. Gomez, Matias Grodzielski, Jacqueline Gonzalez, Karina Marino, Paula G. Heller, Nora P. Goette, Rosana F. Marta
Summary: The study found that systemic lupus erythematosus (SLE) patients with thrombocytopenia have abnormalities in platelet clearance and production, mainly due to apoptosis and desialylation leading to low platelet count. These abnormalities are more frequently observed in patients with thrombocytopenia and active disease.
Article
Biochemistry & Molecular Biology
Luciana Canonero, Constanza Pautasso, Fiorella Galello, Lorena Sigaut, Lia Pietrasanta, Javier Arroyo, Mariana Bermudez-Moretti, Paula Portela, Silvia Rossi
Summary: This study explores the mechanism of the response of the cAMP-PKA pathway to heat shock and thermal adaptation in yeast. The results demonstrate that heat shock leads to the assembly of TPK1 mRNA in cytoplasmic foci, and the protein level of Tpk1 significantly increases during the recovery period. The expression of TPK1 upon heat shock is dependent on the Wsc3 sensor and the CWI signaling pathway. This study reveals the specificity regulation of cAMP-PKA signaling by thermal stress.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Oncology
Xixi Zhao, Yongkun Wei, Yu-Yi Chu, Yintao Li, Jung-Mao Hsu, Zhou Jiang, Chunxiao Liu, Jennifer L. Hsu, Wei-Chao Chang, Riyao Yang, Li-Chuan Chan, Jingkun Qu, Shuqun Zhang, Haoqiang Ying, Dihua Yu, Mien-Chie Hung
Summary: This study reveals the role of CK2 in immunosuppression by phosphorylation and stabilization of PD-L1, and suggests CK2 inhibition as a potential immunotherapeutic approach for treating cancer.
Article
Biochemistry & Molecular Biology
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Weiya Xia, Boning Liu, Yu-Yi Chu, Laura Bover, Long Vien, Mien-Chie Hung
Summary: This study reports the development of two novel Gal-9-neutralizing antibodies that effectively protect human T cells from Gal-9-induced cell death and promote T cell-mediated killing of tumor cells. These findings demonstrate the potential of targeting Gal-9 for cancer immunotherapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Article
Biochemistry & Molecular Biology
C. Fabiani, V. N. Georgiev, D. A. Penalva, L. Sigaut, L. Pietrasanta, J. Corradi, R. Dimova, S. S. Antollini
Summary: Nicotinic acetylcholine receptors (nAChRs) are closely related to the composition and organization of the cell membrane, which in turn affect the function of nAChRs. The membrane's lipid composition and cholesterol distribution play crucial roles in nAChR function.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Nicolas A. Pinto, Martin C. Abba, Lorena Laporte, Juan M. Perez M. Saez, Ada G. G. Blidner, Nicolas I. Torres, Rosa M. M. Morales, Sabrina G. G. Gatto, Camila A. A. Bach, Florencia Veigas, Hernan J. Garcia Rivello, Peng Song, Jane H. H. Frederiksen, Lene Juel Rasmussen, Francoise Poirier, Diego O. O. Croci, Victoria Sundblad, Gabriel A. A. Rabinovich, Juan P. P. Cerliani
Summary: Non-melanoma skin cancer (NMSC) has increased due to chronic exposure to sunlight, climatic changes, and immunosuppression. Gal-7, a protein expressed in skin tissue, plays a critical role in NMSC development. Overexpression of Gal-7 leads to an increase in the number of papillomas in transgenic mice.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Dermatology
Ching-Han Tsao, Wei-Chen Hsieh, Feng-Jen Lin, Ri-Yao Yang, Meng-Ting Chang, Maria Karmella Apaya, Lie -Fen Shyur, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: Sebaceous glands produce lipids that are crucial for maintaining the skin barrier. Galectin-12 protein has been found to regulate sebocyte differentiation and lipid production, playing a positive role in sebaceous lipid metabolism.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Feng-Jen Lin, Yun-Hsi Huang, Ching-Han Tsao, Wei-Chen Hsieh, Yuan-Hsin Lo, Christos C. Zouboulis, Hung-Lin Chen, Fu-Tong Liu
Summary: Sebaceous glands play a role in skin immune response and dysregulated lipid production may contribute to the progression of certain skin diseases. Galectin-12 is a factor that affects the immune response and regulates IL-4 signaling and endoplasmic reticulum stress in sebaceous glands.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Karina V. Marino, Alejandro J. Cagnoni, Diego O. Croci, Gabriel A. Rabinovich
Summary: This article discusses the therapeutic relevance of galectins to cancer and fibrosis, and reviews the various strategies to target galectins and their progress in clinical trials.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Review
Immunology
Fu-Tong Liu, Sean R. Stowell
Summary: Galectins can modulate immune cells by binding to glycosylated proteins and lipids on the cell surface, or intracellularly via carbohydrate-dependent or carbohydrate-independent interactions. This Review explores the diverse ways in which galectins affect immunity and discusses the opportunities and challenges in the field.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ching-Han Tsao, Wei-Chen Hsieh, Ri-Yao Yang, Yuan-Hsin Lo, Ting-Jui Tu, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: In this study, Galectin-12 was identified as an important intracellular regulator of sebocyte proliferation. It modulates cell cycle regulators and PPAR gamma expression to affect the proliferation of sebocytes. These findings suggest the potential of targeting Galectin-12 for the treatment of skin diseases related to sebaceous gland hyperfunction and androgens.