Article
Immunology
Kristina L. Bajema, Ryan Gierke, Monica M. Farley, William Schaffner, Ann Thomas, Arthur L. Reingold, Lee H. Harrison, Ruth Lynfield, Kari E. Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M. Snippes Vagnone, Bernard Beall, Tamara Pilishvili
Summary: The incidence of antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) has decreased in the United States after the introduction of 7- and 13-valent pneumococcal conjugate vaccines (PCVs). However, there has been an increase in nonvaccine type NS-IPD, particularly among older adults. The use of higher valency PCVs containing the common nonsusceptible serotypes could help further reduce NS-IPD.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Ellen Signe Filtenborg Tvedskov, Nichlas Hovmand, Thomas Benfield, Michaela Tinggaard
Summary: This study aims to describe the prevalence of carriage of S. pneumoniae and the impact of vaccination among children aged under five years in low- and lower-middle-income countries since 2012. The study found that the introduction of PCV has led to a decrease in vaccine-type carriage in most countries, but coverage remains moderate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Santiago Alfayate Miguelez, Genoveva Yague Guirao, Ana I. Menasalvas Ruiz, Manuel Sanchez-Solis, Mirian Domenech Lucas, Fernando Gonzalez Camacho, M. Mar Ortiz Romero, Pilar Espejo Garcia, Carmen Guerrero Gomez, Antonio Iofrio de Arce, Laura Moreno Parrado, Rosa M. Sanchez Andrada, Eva Cascales Alcolea, Sebastian Lorente Garcia, Pedro Paredes Reyes, Angela Casquet Barcelo, M. Luisa Lopez Yepes, Juan Jose Vigueras Abellan, Gonzalo Sanz Mateo
Summary: The study found that PCV13 vaccine played a significant role in reducing carriage of vaccine serotypes, but non-vaccine serotypes were more common, and high resistance rates to certain antibiotics were observed.
Article
Immunology
Leore Kotler, David Greenberg, Noga Givon-Lavi, Bart Adriaan van der Beek, Ron Dagan, Shalom Ben-Shimol
Summary: The study evaluated the impact of PCV on pneumococcal carriage rates in healthy and sick children aged 6-23 months, showing a decrease in carriage rates in respiratory diseases but not in healthy children and those without respiratory infections. This suggests a reduction in respiratory infections caused by VT with a stable rate of non-VT in non-respiratory cases.
Article
Immunology
Lassane Kabore, Tolulope Adebanjo, Berthe Marie Njanpop-Lafourcade, Soumeya Ouangraoua, Felix T. Tarbangdo, Bertrand Meda, Srinivasan Velusamy, Brice Bicaba, Flavien Ake, Lesley McGee, Seydou Yaro, Edouard Betsem, Alain Gervaix, Bradford D. Gessner, Cynthia G. Whitney, Jennifer C. Moisi, Chris A. Van Beneden
Summary: Within 3 years of PCV13 implementation in Burkina Faso, substantial reductions in the percentage of pneumococcal carriers with a vaccine-type were documented among children under 5 years old, but not among individuals aged 5 years and above. More time, a change in the PCV13 schedule, or both, may be needed to better control pneumococcal carriage in this setting.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Kristin Andrejko, Buddhika Ratnasiri, Joseph A. Lewnard
Summary: This study reviewed the antimicrobial susceptibility of pneumococcal serotypes among children globally. The results showed geographical and temporal variation in nonsusceptibility, which was associated with biological characteristics of the serotypes. The implementation of PCVs led to an increase in nonsusceptibility among non-PCV serotypes.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Sophie Belman, Sona Soeng, Chansovannara Soputhy, Rebecca Gladstone, Paulina A. Hawkins, Robert F. Breiman, Lesley McGee, Stephen D. Bentley, Stephanie W. Lo, Paul Turner
Summary: Streptococcus pneumoniae is a major cause of childhood mortality globally and in Cambodia. Monitoring genetic shifts and antimicrobial-resistance patterns is crucial for assessing the impact of vaccination campaigns.
MICROBIAL GENOMICS
(2022)
Article
Immunology
Ravinder Kaur, Minh Pham, Karl O. A. Yu, Michael E. Pichichero
Summary: The study found that antibiotic susceptibility of Streptococcus pneumoniae strains isolated from children improved initially after the introduction of PCV13, but began to decrease from 2013 onwards due to the emergence of new serotypes not included in PCV13. These new strains exhibit reduced susceptibility to multiple commonly used antibiotics, compared to the pre-PCV13 era.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Claire von Mollendorf, Mukhchuluun Ulziibayar, Bradford D. Gessner, Lien Anh Ha Do, Cattram D. Nguyen, Rohini Beavon, Bujinlkham Suuri, Dashtseren Luvsantseren, Dorj Narangerel, Adam Jenney, Eileen M. Dunne, Catherine Satzke, Badarchiin Darmaa, Tuya Mungun, E. Kim Mulholland
Summary: This study describes the protocol developed in Mongolia to evaluate the association between childhood PCV13 vaccination and trends in adult pneumonia. By initiating active hospital-based surveillance for adult pneumonia, the study aims to assess the impact of PCV13 introduction on adult pneumonia incidence and related data, contributing to a better understanding of the public health impact of the vaccine.
Article
Medicine, General & Internal
George Qian, Michiko Toizumi, Sam Clifford, Lien Thuy Le, Tasos Papastylianou, Catherine Satzke, Billy Quilty, Chihiro Iwasaki, Noriko Kitamura, Mizuki Takegata, Minh Xuan Bui, Hien Anh Thi Nguyen, Duc Anh Dang, Albert Jan van Hoek, Lay Myint Yoshida, Stefan Flasche
Summary: This study investigates pneumococcal transmission routes to infants in Nha Trang, Vietnam, and finds that preschool-age children may be the largest reservoir for pneumococcal transmission to infants.
Article
Immunology
Carlo Casanova, Marianne Kuffer, Stephen L. Leib, Markus Hilty
Summary: In Switzerland during the first six months of 2021, the incidence of invasive pneumococcal disease rebounded as COVID-19 measures were relaxed, with the emergence of non-vaccine type serotype 23B which is associated with reduced susceptibility to penicillin. This highlights the importance of monitoring and addressing potential changes in disease patterns in the context of ongoing public health crises.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Louise K. Francois Watkins, Jennifer L. Milucky, Lesley McGee, Florence Sine St-Surin, Pengbo Liu, Theresa Tran, Sopio Chochua, Gerard Joseph, Nong Shang, Stanley Juin, Patrick Dely, Roopal Patel, Chris A. Van Beneden
Summary: In Port-au-Prince, Haiti, approximately a quarter of healthy children were colonized with vaccine-type pneumococcal serotypes, indicating potential impact of PCV13 introduction nationwide in reducing pneumococcal carriage.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Wa Ode Dwi Daningrat, Hafsah Amalia, Ira Marti Ayu, Catherine Satzke, Dodi Safari
Summary: We conducted a systematic review and meta-analysis to summarize the prevalence of serotypes of Streptococcus pneumoniae carried in the nasopharynx of children under 5 years of age in the South East Asia Region (SEAR). The pooled prevalence of S. pneumoniae in healthy children under 5 years of age in SEAR was 36.0% and varied among countries, ranging from 68.0% in Cambodia to 7.6% in Malaysia. Serotypes 6A/B, 23F, and 19F were the most common among children <5 years. These findings highlight the importance of considering regional data when implementing pneumococcal conjugate vaccine programs and the need for more comprehensive and updated information on serotype epidemiology in SEAR.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Jordi Camara, Inmaculada Grau, Aida Gonzalez-Diaz, Fe Tubau, Laura Calatayud, Meritxell Cubero, M. Angeles Dominguez, Josefina Linares, Jose Yuste, Roman Pallares, Carmen Ardanuy
Summary: The study revealed an overall reduction of MDR/PNS isolates in adults after the introduction of pneumococcal conjugate vaccines. However, a significant proportion of current resistant isolates are not covered by any of the upcoming PCV15/PCV20 vaccines. The burden of resistant disease is related to older patients with underlying conditions and caused by two major clones. Data show that MDR is not statistically significant in relation to increased mortality.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Stefanie Desmet, Heidi Theeten, Lies Laenen, Lize Cuypers, Piet Maes, Wouter Bossuyt, Liesbet Van Heirstraeten, Willy E. Peetermans, Katrien Lagrou
Summary: After switching from PCV13 to PCV10, there was a rapid reemergence of serotype 19A invasive pneumococcal disease in children in Belgium. Whole-genome sequencing revealed 24 sequence types, with ST416 and ST994 being predominant during the PCV10 period.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Miika Linna, Juha Laine, Leena Timonen, Heidi Ahman, Myint Tin Tin Htar
CURRENT MEDICAL RESEARCH AND OPINION
(2018)
Review
Multidisciplinary Sciences
Myint Tin Tin Htar, Anke L. Stuurman, Germano Ferreira, Cristiano Alicino, Kaatje Bollaerts, Chiara Paganino, Ralf Rene Reinert, Heinz-Josef Schmitt, Cecilia Trucchi, Thomas Vestraeten, Filippo Ansaldi
Article
Multidisciplinary Sciences
Dace Zavadska, Zane Odzelevica, Guntis Karelis, Lelde Liepina, Zane Anna Litauniece, Antra Bormane, Irina Lucenko, Jurijs Perevoscikovs, Linda Bridina, Laura Veide, Angelika Krumina, Jelena Storozenko, Wilhelm Erber, Myint Tin Tin Htar, Heinz-Josef Schmitt
Article
Immunology
Laurence Torcel-Pagnon, Vincent Bauchau, Patrick Mahy, Myint Tin Tin Htar, Marianne van der Sande, Cedric Mahe, Tyra Grove Krause, Anne Charrat, Francois Simondon, Xavier Kurz
Review
Immunology
Myint Tin Tin Htar, Heather L. Sings, Maria Syrochkina, Bulent Taysi, Betsy Hilton, Heinz-Josef Schmitt, Bradford D. Gessner, Luis Jodar
EXPERT REVIEW OF VACCINES
(2019)
Review
Immunology
Myint Tin Tin Htar, Jose Morato Martinez, Christian Theilacker, Heinz-Josef Schmitt, David Swerdlow
EXPERT REVIEW OF VACCINES
(2019)
Article
Immunology
Myint Tin Tin Htar, Maria de Ridder, Toon Braeye, Ana Correa, Chris McGee, Simon de Lusignan, Talita Duarte-Salles, Consuelo Huerta-Alvarez, Elisa Martin-Merino, Lara Tramontan, Giorgia Danieli, Gino Picelli, Nicoline van der Maas, Klara Berencsi, Lisen Arnheim-Dahlstrom, Ulrich Heininger, Hanne-Dorthe Emborg, Daniel Weibel, Kaatje Bollaerts, Miriam Sturkenboom
Review
Public, Environmental & Occupational Health
M. Tin Tin Htar, M. S. Yerramalla, J. C. Moisi, D. L. Swerdlow
EPIDEMIOLOGY AND INFECTION
(2020)
Review
Infectious Diseases
Emma-Pascale Chevalier-Cottin, Hayley Ashbaugh, Nicholas Brooke, Gaetan Gavazzi, Mauricio Santillana, Nansa Burlet, Myint Tin Tin Htar
INFECTIOUS DISEASES AND THERAPY
(2020)
Review
Public, Environmental & Occupational Health
Myint Tin Tin Htar, Sally Jackson, Paul Balmer, Lidia Cristina Serra, Andrew Vyse, Mary Slack, Margarita Riera-Montes, David L. Swerdlow, Jamie Findlow
Article
Infectious Diseases
Charles Nuttens, Jamie Findlow, Paul Balmer, David L. Swerdlow, Myint Tin Tin Htar
Summary: This study analyzed the evolution of invasive meningococcal disease (IMD) epidemiology in Europe from 2008 to 2017. Overall incidence of IMD decreased, but there were increases in the incidence of serogroups W and Y, as well as in the older population. It is recommended to adjust vaccination strategies based on epidemiological changes.
Article
Multidisciplinary Sciences
Liping Huang, Stephane Fievez, Melanie Goguillot, Lucile Marie, Steve Benard, Anne Elkaim, Myint Tin Tin Htar
Summary: This study examines the clinical characteristics, healthcare resource utilization, and costs associated with invasive meningococcal disease (IMD) in France. The results highlight the severity and economic burden of IMD and emphasize the importance of vaccination for prevention.
Review
Public, Environmental & Occupational Health
Carmen Pardo de Santayana, Myint Tin Tin Htar, Jamie Findlow, Paul Balmer
Summary: This article describes the epidemiology of invasive meningococcal disease (IMD), including its incidence trends and serogroup distribution across different regions and age groups. Data from surveillance reports and published articles from 2010 to 2019 in 77 countries were analyzed, showing a low global incidence of IMD with significant variability in circulating disease-causing serogroups. Infants had the highest incidence, followed by young children, adolescents/young adults, and older adults in some countries. Serogroup B was the predominant cause of IMD globally, but there was a notable increase in cases caused by serogroups W and Y from 2010 to 2019 in several regions, highlighting the unpredictable and dynamic nature of the disease. Serogroups A, B, C, W, and Y accounted for the majority of IMD cases despite the availability of vaccines.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Immunology
Kaatje Bollaerts, Tom de Smedt, Chris McGee, Hanne-Dorthe Emborg, Marco Villa, Maria Alexandridou, Talita Duarte-Salles, Rosa Gini, Claudia Bartolini, Simon de Lusignan, Myint Tin Tin Htar, Lina Titievsky, Miriam Sturkenboom, Vincent Bauchau
