Article
Engineering, Biomedical
Xin Wang, Baokun Zhang, Zhiheng Chen, Qiang Shi, Erzhu Yang, Jianguang Xu, Xiaofeng Lian
Summary: Following spinal cord injury, the disruption of the blood-spinal cord barrier (BSCB) and hemorrhage lead to progressive secondary injuries. Bazedoxifene, a third-generation estrogen receptor modulator, has been found to inhibit inflammation and blood-brain barrier disruption caused by traumatic brain injury. In this study, a new biomaterial carrier was developed to deliver Bazedoxifene to the site of spinal cord injury and effectively attenuate BSCB disruption through the NF-KB pathway, providing potential therapeutic benefits for spinal cord repair.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Hougang Xia, Dandan Wang, Xiaohui Guo, Kaidi Wu, Fuwei Huang, Yanjiang Feng
Summary: The study revealed that treatment with CTP could improve functional recovery in SCI mice, suppress apoptosis, alleviate inflammatory response, and oxidative stress. Moreover, CTP was found to regulate the HMGB1/TLR4/NF-kappa B pathway through miR-142, thus providing protective effects against apoptosis, inflammation, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hongbo Wu, Yi Li, Xiaofeng Wang, Zhiwen Zhang, Yuliang Huang
Summary: The study revealed that TUG1 is up-regulated in ASCI rats and hypoxic cells, and interacts with miR-338 to regulate BIK expression, thereby affecting cell death. TUG1 silencing can alleviate death in neurons and ASCI models by modulating the miR-338/BIK axis.
Article
Biochemistry & Molecular Biology
Xianqiu Wu, Yang Liu, Song Mo, Wuli Wei, Ziliang Ye, Qiang Su
Summary: The study revealed the significance of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 axes in MIRI, promoting myocardial ischemia-reperfusion injury by affecting cell survival and apoptosis.
Review
Biotechnology & Applied Microbiology
Bin Lv, Naiting Shen, Zhangrong Cheng, Yuhang Chen, Hua Ding, Jishan Yuan, Kangchen Zhao, Yukun Zhang
Summary: The TLR4-NF-κB signaling pathway plays an important role in the recovery after spinal cord injury (SCI). It can alleviate inflammatory responses, modulate autophagy, apoptosis and ferroptosis, and enhance the anti-oxidative effect. Novel biomaterials as scaffolds and carriers have been designed to regulate TLR4-NF-κB and inhibit the progression of SCI.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Heng-Jun Zhou, Li-Qing Wang, Ren-Ya Zhan, Xiu-Jue Zheng, Jie-Sheng Zheng
Summary: This study found that the expression of lncRNA MEG3 is decreased in ASCI, but its overexpression can inhibit the M1 polarization of microglia and neuroinflammation by regulating the NF-kappa B signaling pathway, thus promoting the recovery of spinal cord injury.
Article
Multidisciplinary Sciences
Jiahuan Wu, Xiangzhe Li, Qinghua Wang, Sheng Wang, Wenhua He, Qinfeng Wu, Chuanming Dong
Summary: This study investigates the effects of exercise therapy on the expression levels of noncoding RNAs in rats with spinal cord injury (SCI) and the role of competing endogenous RNA (ceRNA) regulation mechanisms in this therapy. The results suggest that exercise therapy may exert its therapeutic effects on SCI through the modulation of lncRNA, miRNA, and mRNA expression.
Article
Immunology
Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge
Summary: The study showed that silencing HSPA8 can alleviate spinal cord damage caused by SCII by inhibiting astrocyte activation and NF-κB, NLRP3 inflammasome activation, leading to reduced neuroinflammation and protection of neurons.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biotechnology & Applied Microbiology
Dexiang Ban, Peng Yu, Zhenyang Xiang, Yang Liu
Summary: The TWEAK/NF-kappa B pathway plays an important role in the non-canonical signaling pathways. Inhibiting this pathway can restrain the excessive growth of astrocytes and promote the growth of neurons. These findings have important implications for the treatment of spinal cord injury.
Review
Orthopedics
Dayu Pan, Weixiao Liu, Shibo Zhu, Baoyou Fan, Nanxi Yu, Guangzhi Ning, Shiqing Feng
Summary: Spinal cord injury is a devastating global issue, and a profound understanding of the pathology and etiology of SCI is crucial for new therapeutic concepts. In recent years, exosomes have emerged as a promising new field for SCI treatment, with the advantage of transporting valuable materials to target cells and exerting regulatory functions. Among these, microRNAs show great potential in the pathological process and treatment of SCI through modulation of mRNA targets.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Cell Biology
Tao Zhang, Kang Li, Zi-Lu Zhang, Kai Gao, Chao-Liang Lv
Summary: The study found that lncRNA Airsci alleviated the inflammatory response after SCI by inhibiting the NF-kappa B signaling pathway and promoted motor function recovery in rats. Numerous lncRNAs were differentially expressed following SCI, with Airsci being the most significantly expressed and playing a key role in the NF-kappa B signaling pathway.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Xuezhen Ma, Xuesong Wang, Xuexiao Ma, Xiugong Zhang, Xiaojin Gong, Ruifu Sun, Sunny H. Wong, Matthew T. Chan, William Ka Kei Wu
Summary: Spinal cord injury (SCI) is a disabling condition with limited therapeutic options. Recent studies have shown altered expression of circular RNAs (circRNAs) in the damaged tissue, which play a role in cellular processes relevant to SCI repair and regeneration. However, further investigation is needed to efficiently deliver these regulatory molecules in a cell-type specific manner before translating these findings into clinical benefits.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Yuying Li, Huiping Qiu, Shuihong Yao, Qunfeng Li, Yuemin Ding, Yanhui Cao, Xuming Chen, Xiaoping Zhu
Summary: The study shows that Gen can promote the recovery of SCI rats, reduce inflammation, and enhance motor function and axon regeneration by inhibiting the IKKs/NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Wenbin Zhang, Mengxian Jia, Jiashu Lian, Sheng Lu, Jian Zhou, Ziwei Fan, Zhoule Zhu, Yaozhi He, Changgang Huang, Mingyu Zhu, Jian Wang, Ying Wang, Zhihui Huang, Honglin Teng
Summary: TBK1 plays an important role in the pathogenesis of spinal cord injury (SCI) by mediating innate immune pathways in astrocytes through YAP signaling. Inhibition of TBK1 activity alleviates neuroinflammation, reduces motor neuron loss, and improves functional recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a traumatic central nervous system injury that can lead to severe nerve damage. Inflammatory response plays a crucial role in secondary injury. Prolonged inflammation can worsen the injured site's microenvironment, resulting in neural function deterioration. Understanding the NF-kappa B pathway and its regulation of inflammation after SCI is crucial for developing new therapies. Inhibiting the NF-kappa B pathway improves the inflammatory microenvironment and enhances neural function recovery, making it a potential therapeutic target for SCI.
MOLECULAR NEUROBIOLOGY
(2023)