Article
Biotechnology & Applied Microbiology
Shifang Deng, Lei Yang, Ke Ma, Wei Bian
Summary: Astragalus polysaccharide treatment improved proliferation and insulin secretion in HG+PA-treated MIN6 cells partially by promoting miR-136-5p and miR-149-5p expression to inhibit EFHD2 expression.
Article
Medicine, Research & Experimental
Runyu Du, Na Wu, Yu Bai, Lei Tang, Ling Li
Summary: This study found that circMAP3K4, highly expressed in the placentas of patients with gestational diabetes mellitus (GDM) and the insulin resistance (IR) trophoblast model, is associated with dysregulated insulin-PI3K/Akt pathway. circMAP3K4 may suppress the insulin-PI3K/Akt signaling pathway via the miR-6795-5p/PTPN1 axis, contributing to GDM-related insulin resistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Weiqi Ke, Yixiang Chen, Lijing Zheng, Yuting Zhang, Yudan Wu, Li Li
Summary: The study revealed that miR-134-5p is upregulated in GDM patients and can serve as a critical diagnostic marker; inhibition of miR-134-5p can alleviate inflammation and apoptosis in GDM cells; miR-134-5p suppresses FOXP2 expression to facilitate inflammation and apoptosis of trophoblast cells, exacerbating GDM.
Article
Pharmacology & Pharmacy
Yinqin Cheng, Qiaosheng Hu, Jie Zhou
Summary: The study showed that PVT1 was upregulated after STZ stimulation, and silencing PVT1 inhibited oxidative stress and cell apoptosis while enhancing insulin secretion. The luciferase reporter assay confirmed PVT1 directly targeted miR-181a-5p, with rescue assays demonstrating abolishment of the effects of PVT1 silencing by miR-181a-5p inhibitor.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Geng Li, Linghui Zhang
Summary: The dysregulation of miR-335-5p and SLC2A4 in T2D patients has been identified, with implications on proliferation and apoptosis of pancreatic cells. Targeting SLC2A4 via miR-335-5p could potentially hinder the growth of T2D cells by inhibiting proliferation and elevating apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Xinyang Yu, Zhengfei Liu, Jie Fang, Hongbo Qi
Summary: miR-96-5p plays a significant role in diagnosing gestational diabetes mellitus (GDM), with decreased levels in both placenta and plasma samples of patients with GDM. It can serve as a diagnostic biomarker for GDM with high sensitivity and specificity, and may participate in the pathogenesis of GDM by affecting the viability of trophoblasts.
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sepideh Kadkhoda, Mohammad Taheri, Arash Tafrishinejad
Summary: This review summarizes the impact and mechanisms of miR-149-5p in tumorigenesis in various neoplastic conditions, based on evidence from in vitro, in vivo, and clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yat-Yin Law, Wei-Fang Lee, Chin-Jung Hsu, Yen-You Lin, Chun-Hao Tsai, Chien-Chung Huang, Min-Huan Wu, Chih-Hsin Tang, Ju-Fang Liu
Summary: The research on OA and RA revealed that miR-let-7c-5p and miR-149-5p have inhibitory effects on the transcription of proinflammatory cytokines, suggesting that increasing the expression of these two miRNAs is a novel therapeutic strategy for OA and RA.
Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Cell Biology
Wen Tian, He Yang, Baosen Zhou
Summary: Exosomal miR-149-5p in lung adenocarcinoma promotes tumor cell growth and inhibits apoptosis, with the target gene AMOTL2 being a potential independent risk factor for poor survival. This study provides specific insights for further mechanistic studies on lung adenocarcinoma.
Article
Biochemistry & Molecular Biology
Sai Zhu, Xin Chen, Jia-Nan Wang, Jin-Jin Xu, Ao Wang, Juan-Juan Li, Sha Wu, Yuan-Yuan Wu, Xiao-Feng Li, Cheng Huang, Jun Li
Summary: The study revealed that circUbe2k plays a significant role in regulating the development of hepatic fibrosis by acting as a catalyst for HSCs activation and proliferation. Additionally, a direct interaction between circUbe2k and miR-149-5p was found to modulate TGF-beta 2 expression, indicating its involvement in the pathogenesis of hepatic fibrosis. These findings suggest circUbe2k could serve as a potential biomarker for hepatic fibrosis therapy.
Article
Medicine, Research & Experimental
Xin Shen, Weiwen Zhu, Ping Zhang, Yu Fu, Jie Cheng, Laikui Liu, Rongyao Xu, Hongbing Jiang
Summary: This study reveals the inhibitory effect of zoledronic acid (ZA)-treated macrophages on bone resorption and vascular formation during tooth extraction socket healing. ZA activates the NF-KB signaling pathway and promotes the transcription of miR-149-5p in macrophages, leading to impaired osteoclast differentiation. Moreover, extracellular vesicles derived from ZA-treated macrophages can regulate the function of endothelial cells through the Rap1a/Rap1b/VEGFR2 pathway. Chemically modified antagomiR-149-5p shows therapeutic effectiveness in BRONJ mice.
Article
Multidisciplinary Sciences
Jing He, Jiayang Song, Zhijie Zou, Xiaoxiao Fan, Ruixue Tian, Jingqi Xu, Yu Yan, Jinbing Bai, Zhen Chen, Yanqun Liu, Xiaoli Chen
Summary: This retrospective study aimed to investigate the correlation between neonatal hyperbilirubinemia (NHB) and hypoglycemia (NH) in Chinese women with diabetes in pregnancy (DIP), and the influencing factors. The study found that NHB and NH were significantly correlated in women with DIP, and increased gestational age and abnormal placental morphology were associated with NH and NHB.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Shengqiang Fu, Qiaoyun Fan, Juntao Xu, Shengjun Yu, Ming Sun, Yuan Ji, Dun Liu
Summary: Circular RNA circ_0008956 is highly expressed in OA and acts as a sponge for miR-149-5p to up-regulate NAMPT expression, contributing to IL-1 beta-induced growth arrest and ECM degradation. This study provides new insights into the pathogenesis of OA and identifies a potential therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rajan Singh, Se Eun Ha, Lai Wei, Byungchang Jin, Hannah Zogg, Sandra M. Poudrier, Brian G. Jorgensen, Chanjae Park, Charles F. Ronkon, Allison Bartlett, Sung Cho, Addison Morales, Yu Heon Chung, Moon Young Lee, Jong Kun Park, Andres Gottfried-Blackmore, Linda Nguyen, Kenton M. Sanders, Seungil Ro
Summary: miR-10b-5p plays a key role in diabetes and gastrointestinal dysmotility through the KLF11-KIT pathway, and restoring miR-10b-5p may provide therapeutic benefits for these disorders.