Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Article
Endocrinology & Metabolism
Yiyun Lou, Zhujing Fu, Ye Tian, Minhao Hu, Qijing Wang, Yuanyuan Zhou, Ning Wang, Qin Zhang, Fan Jin
Summary: The study found that the decrease in progesterone and estradiol (E-2) levels during threatened miscarriages was associated with reduced expression of SGK1 in decidual macrophages. The activation of E-2-sensitive SGK1 was found to promote macrophage polarization and immune regulation at the maternal-fetal interface. These findings provide new insights into potential preventative strategies for recurrent pregnancy loss.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Hong Zhen, Hongbo Hu, Guojie Rong, Xiuxiu Huang, Chang Tan, Xinyuan Yu
Summary: Administration of vitamin A or vitamin D can alleviate BPD-linked pulmonary injury induced by LPS and have a significant impact on macrophage polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Jiuyang Liu, Xiafei Geng, Jinxuan Hou, Gaosong Wu
Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Antong Wu, Janak Lal. Pathak, Xingyang Li, Wei Cao, Wenchao Zhong, Mingjing Zhu, Qiuyu Wu, Wanyi Chen, Qiao Han, Siqing Jiang, Yuzhuo Hei, Ziyi Zhang, Gang Wu, Qingbin Zhang
Summary: In this study, the efficacy of human salivary peptide histatin-1 (Hst1) in attenuating bone and cartilage damage in osteoarthritis (OA) was investigated. Hst1 was found to significantly attenuate cartilage and bone deconstruction as well as macrophage infiltration. It also triggered M1-to-M2 macrophage phenotype switching and restored the metabolic activity, migration, and chondrogenic differentiation of chondrogenic cells.
Article
Spectroscopy
Ana Rubia Batista Ribeiro, Elaine Cristina Oliveira Silva, Polliane Maria Cavalcante Araujo, Samuel Teixeira Souza, Eduardo Jorge da Silva Fonseca, Emiliano Barreto
Summary: This study utilized Raman spectroscopy to analyze the polarization of macrophages, successfully distinguishing between M1 and M2 phenotypes through principal component analysis, reflecting changes in cell markers due to differentiation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Z. N. Mihalic, T. Kloimboeck, N. Cosic-Mujkanovic, P. Valadez-Cosmes, K. Maitz, O. Kindler, C. Wadsack, A. Heinemann, G. Marsche, M. Gauster, J. Pollheimer, J. Kargl
Summary: This study reveals that internalization and activity of myeloperoxidase (MPO) enhances migration and invasion of JEG-3 cells, suggesting a potential role of MPO in both normal and abnormal pregnancies.
Review
Immunology
Ping Jiang, Xiaopeng Li
Summary: Precise expression and regulation of genes in the immune system are crucial for generating strong immune responses and preventing autoimmune diseases. Recent studies have shown that long noncoding RNAs play a significant role in immune function by regulating immune cell differentiation, development, and function. These RNAs can control the polarization of immune cells, promote pro-inflammatory or anti-inflammatory effects, and contribute to the pathogenesis of various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anatomy & Morphology
Hengfang Zhang, Shuang Zhang, Xuan Dang, Lexun Lin, Liping Ren, Rong Song
Summary: Macrophages play a crucial role in the development of periodontitis and their phenotype is influenced by GPNMB protein. Overexpression of GPNMB in macrophages was found to enhance the secretion of anti-inflammatory factors and inhibit the secretion of pro-inflammatory factors.
Article
Cell & Tissue Engineering
Rui Li, Dize Li, Huanan Wang, Kaiwen Chen, Si Wang, Jie Xu, Ping Ji
Summary: This study found that exosomes secreted by adipose-derived stem cells play an immunomodulatory role in traumatic bone defects. They regulate macrophage immunity and promote bone tissue healing, partly through the immune regulation of miR-451a.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wenya Zhu, Qianqian Chen, Yi Li, Jun Wan, Jia Li, Shuai Tang
Summary: A modified MSC transplantation with overexpression of HIF-1 alpha is an effective treatment for IBD. HIF-MSCs attenuate colitis and restore immune balance through regulating macrophage polarization via PI3K-gamma. The findings suggest that HIF-MSC transplantation is a potential precision therapy for IBD.
Article
Cell Biology
Paschalia Pantazi, Toby Clements, Morten Veno, Vikki M. Abrahams, Beth Holder
Summary: This study provides the first comprehensive analysis of the small RNA cargo of extracellular vesicles (EVs) from human M1 and M2 macrophages. The results show distinct differences in the small RNA profiles between M1 and M2 EVs, including higher relative abundance of miRNAs and lower abundance of tRNA fragments in M1 EVs. The study suggests that these different RNA cargos in M1 and M2 EVs contribute to the unique effects of these macrophage subsets on their microenvironment.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Immunology
Sheyda Bahiraii, Martin Brenner, Fangfang Yan, Wolfram Weckwerth, Elke H. Heiss
Summary: This study reveals that sulforaphane (Sfn) inhibits the expression of proinflammatory markers in M1 macrophages and enhances cellular energy levels. By impeding the function of pyruvate kinase M2 (PKM2), Sfn alters the glycolytic activity and IL-1β expression in macrophages, thus influencing the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lisa Hirahara, Kaoru Takase-Minegishi, Yohei Kirino, Yuki Iizuka-Iribe, Yutaro Soejima, Ryusuke Yoshimi, Hideaki Nakajima
Summary: Behcet's disease is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. The pathogenesis of BD is not fully understood, but it is likely a result of genetic susceptibility and environmental factors. This review discusses the roles of monocytes and macrophages in BD and their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Wael M. Seoudy, Sara M. Mohy El Dien, Talal A. Abdel Reheem, Mona M. Elfangary, Moatasem A. Erfan
Summary: This study suggests that M1 and M2 macrophages play important roles in the pathogenesis of keloid formation. Keloid formation might be a result of an abnormal response to tissue injury with excessive entry of inflammatory cells, including macrophages, into the wound, and the incidence of keloid might be related to a decrease in M1 and an increase in M2.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Wendy Fitzgerald, Roberto Romero, Nardhy Gomez-Lopez, Dereje W. Gudicha, Nandor Gabor Than, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Eunjung Jung, Arun Meyyazhagan, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca, Leonid Margolis
Summary: This study aimed to characterize the proteomic profile of extracellular vesicles (EVs) in the plasma of pregnant women with fetal death and evaluate their association with the pathophysiology of this complication. The results showed that there were differences in the concentrations of 19 proteins in the EVs and soluble fractions of women with fetal death compared to controls, and these changes were consistent between the two fractions. The combination of EV and soluble protein concentrations revealed three distinct clusters of fetal death cases with different clinical and placental histopathological characteristics.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Mariachiara Bosco, Roberto Romero, Dahiana M. Gallo, Manaphat Suksai, Francesca Gotsch, Eunjung Jung, Piya Chaemsaithong, Adi L. Tarca, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Arun Meyyazhagan, Malek Al Qasem, Massimo P. Franchi, Lawrence I. Grossman, Siddhesh Aras, Tinnakorn Chaiworapongsa
Summary: This study aimed to determine the concentrations of CHCHD2/MNRR1 in amniotic fluid of pregnant women, women at term in labor, and those in preterm labor. The results showed that CHCHD2/MNRR1 is a physiological constituent of amniotic fluid in normal pregnancy, and its concentration increases in amniotic fluid associated with intra-amniotic infection during pregnancy, term labor, and preterm labor.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)
Article
Medicine, General & Internal
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Derek Miller, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Andrew D. Winters, Bruce A. Berkowitz, Robert H. Podolsky, Yimin Shen, Tomi Kanninen, Bogdan Panaitescu, Catherine R. Glazier, Roger Pique-Regi, Kevin R. Theis, Nardhy Gomez-Lopez
Summary: This study investigates the role of IL-6 and IL-1 alpha in sterile intra-amniotic inflammation (SIAI) and their impact on preterm birth and neonatal outcomes. The researchers found that IL-6 plays a critical role in the inflammatory response and that IL-1 alpha injection leads to preterm birth and neonatal mortality. Prenatal treatment with an IL-6R blockade shows promising results in preventing preterm birth and improving neonatal outcomes.