Article
Oncology
Yongyue Dai, Yucheng Zhang, Maolin Hao, Renwu Zhu
Summary: In glioma, high expression of LINC00665 promotes proliferation and invasion of tumor cells by competitively binding to miR-34a-5p to regulate AGTR1 expression.
Article
Cell Biology
Yazhen Xu, Bingyu Guo, Xiaoyan Liu, Kai Tao
Summary: miR-34a inhibits melanoma growth by targeting ZEB1, suggesting a potential novel target for melanoma treatment.
Article
Medicine, Research & Experimental
Nastaran Injinari, Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Hossein Teimori
Summary: miR-34a and miR-520h are implicated in the apoptosis pathways, with decreased expression in cancer tissues and VPA inducing apoptosis and affecting their expression. VPA can be a possible option in breast cancer research due to its impact on the regulation of miRNAs and HDAC1.
Article
Biotechnology & Applied Microbiology
Jaya Bharati, N. H. Mohan, Satish Kumar, Jayashree Gogoi, Sai Kumar, Bosco Jose, Meeti Punetha, Sanjib Borah, Amit Kumar, Mihir Sarkar
Summary: RNA-Seq was used to identify differentially expressed genes (DEGs) in porcine corpus luteum (CL) during different physiological stages, revealing significant enrichment of gene functions in early, mid, and late stages. Apoptosis was most active in the regressed stage. Pathway analysis indicated lipid metabolism, translation, immune, and endocrine system pathways were associated with CL function. Gene network analysis identified novel hub genes AR, FOS, CDKN1A potentially regulating CL physiology.
Article
Chemistry, Multidisciplinary
Esra Dirimtekin, Maria Mortoglou, Ceren Alavanda, Asmaa Benomar Yemlahi, Esra Arslan Ates, Ilter Guney, Pinar Uysal-Onganer
Summary: miR-34a is downregulated and associated with inhibition of tumor growth and invasion in ovarian cancer, while FOXP1 is reported as either an oncogene or tumor suppressor. It is found that miR-34a and FOXP1 are reversely correlated, and inhibition of miR-34a leads to upregulation of FOXP1 expression and increased cellular invasion. miR-34a could be a potential biomarker for improving the diagnostic efficiency of ovarian cancer, and its overexpression may reduce pathogenesis by targeting FOXP1.
Article
Oncology
Narjes Jafari, Saeid Abediankenari, Hadi Hossein-Nataj
Summary: The study revealed that the effect of miR mimic in target gene repression may depend on its concentration and cell type, while pre-miRNAs may have a regulatory function in target repression. These findings will help to develop effective therapeutic strategies in cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Nermeen Z. Abuelezz, Fayza Eid Nasr, Waleed M. Abdel Aal, Tarek Molokhia, Amira Zaky
Summary: The study found that serum miR-34a, miR-29b, and miR-181c were significantly downregulated in AD patients and associated with cognitive decline. AD patients also showed elevated levels of Aβ42, pTau, and TNF-α. The measured miRNAs had good AD diagnostic value alone and when combined with other biomarkers, significantly improving diagnostic power.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Neurosciences
Iveta Herichova, Barbora Tesakova, Lucia Krskova, Lucia Olexova
Summary: This study focuses on how the peripheral circadian oscillator in the prefrontal cortex contributes to food reward-induced activity. It was found that animals with access to a food reward showed more accurate phase shifts in response to a new light cycle, along with rhythmic expression of dopamine receptors in the PFC. The involvement of miR-34a-5p in reward-facilitated synchronisation, particularly in its mature form, was also suggested by the findings.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Reproductive Biology
Patrycja Witek, Malgorzata Grzesiak, Malgorzata Kotula-Balak, Marek Koziorowski, Maria Slomczynska, Katarzyna Knapczyk-Stwora
Summary: Recent studies have shown that neonatal exposure to environmental endocrine-active compounds (EACs) can lead to morphological and functional changes in the porcine corpus luteum (CL). By analyzing the impact of EACs on global DNA methylation and miRNA biogenesis components in the CL, researchers aim to unravel the regulatory mechanisms underlying the long-term effects. The changes in DNA methylation and altered miRNA biogenesis components appear to play a role in mediating the long-term effects of EACs on CL function in pigs.
Article
Ophthalmology
Junji Hamuro, Kazuko Asada, Morio Ueno, Tomoko Yamashita, Atsushi Mukai, Tomoko Fujita, Eiko Ito, Nao Hiramoto, Munetoyo Toda, Chie Sotozono, Shigeru Kinoshita
Summary: This study investigated the mechanism underlying the functional disparity between degenerated and non-degenerated corneal endothelium cells, focusing on the role of microRNAs and associated proteins. The results demonstrate that oxidative stress can impair mitochondrial metabolic homeostasis and impact water efflux from the corneal stroma, leading to corneal endothelial failure.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lei Dai, Weidong Zhang, Yinchun Wang, Kejie Yu, Qi Le, Xianjiang Wu
Summary: This study analyzed the dysregulated profile of circular RNAs (circRNAs) in papillary thyroid cancer (PTC) tissues and found that circAGTPBP1 was upregulated and correlated with tumor characteristics. The downstream targets of circAGTPBP1 were identified as miR-34a-5p and NOTCH1. Functional experiments showed that circAGTPBP1 knockdown inhibited PTC cell migration, invasion, and metastasis, and miR-34a-5p inhibitor reversed these effects. CircAGTPBP1 knockdown also inhibited tumor growth in vivo, suggesting its potential as a therapeutic target for PTC.
Article
Oncology
Jingbing Lou, Hongliang Zhang, Jiuhui Xu, Tingting Ren, Yi Huang, Xiaodong Tang, Wei Guo
Summary: Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor with unclear pathological mechanisms. This study found that circUSP34 promotes the proliferation, migration, and invasion of OS by sponging miR-16-5p, suggesting it as a potential therapeutic target and biomarker.
Article
Multidisciplinary Sciences
Omayma O. Abdelaleem, Shereen Rashad Mohammed, Hassan S. El Sayed, Sherin Khamis Hussein, Doaa Y. Ali, Mostafa Y. Abdelwahed, Sylvana N. Gaber, Nada F. Hemeda, Rehab G. Abd El-Hmid
Summary: This study found that serum levels of miR-34a-5p and miR-199a-3p were significantly reduced in neonates with sepsis, and they were associated with the severity of sepsis.
Article
Cell & Tissue Engineering
Chenchen Pi, Cao Ma, Huan Wang, Hui Sun, Xiao Yu, Xingyu Gao, Yue Yang, Yanan Sun, Haiying Zhang, Yingai Shi, Yan Li, Yulin Li, Xu He
Summary: The study revealed the significant role of miR-34a in mediating MSC replicative senescence and natural senescence by targeting Nampt and further modulating the NAD(+)-Sirt1 pathway, which carries important implications for optimal strategies for MSC therapeutic applications.
STEM CELL RESEARCH & THERAPY
(2021)
