Journal
BIOLOGY OF REPRODUCTION
Volume 94, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.115.136051
Keywords
assisted reproductive technology; genomic imprinting; intrauterine growth trajectory; nutrient transporters; placenta
Categories
Funding
- National Natural Science Foundation of China [81300531, 8137071]
- National Basic Research Program of China [2012 CB944900]
- Scientific and Technical Innovatory Project of Shaanxi Province [2013KTCL03-07]
Ask authors/readers for more resources
Alteration of intrauterine growth trajectory is linked to metabolic diseases in adulthood. In mammalian and, specifically, human species, pregnancies through assisted reproductive technology (ART) are associated with changes in intrauterine growth trajectory. However, it is still unclear how ART alters intrauterine growth trajectory, especially reduced fetal growth in early to midgestation. In this study, using a mouse model, it was found that ART procedures reduce fetal and placental growth at Embryonic Day 10.5. Furthermore, ART leads to decreased methylation levels at H19, KvDMR1, and Snrpn imprinting control regions in the placentae, instead of fetuses. Furthermore, in the placenta, ART downregulated a majority of parentally expressed imprinted genes, which enhance fetal growth, whereas it upregulated a majority of maternally expressed genes which repress fetal growth. Additionally, the expression of genes that regulate placental development was also affected by ART. ART also downregulated a majority of placental nutrient transporters. Disruption of genomic imprinting and abnormal expression of developmentally and functionally relevant genes in placenta may influence the placental development and function, which affect fetal growth and reprogramming.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available