Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 49, Issue 12, Pages 2127-2133Publisher
WILEY
DOI: 10.1002/eji.201847536
Keywords
Autoimmunity; C-type lectin; Dectin-1; Immunity
Categories
Funding
- Wellcome Trust [102705, 097377]
- Medical Research Council Centre for Medical Mycology
- University of Aberdeen [MR/N006364/1]
- Jikei University School of Medicine
- MRC [MR/N006364/1, MR/N006364/2] Funding Source: UKRI
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C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1, and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, is involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis, and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease.
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