Article
Immunology
Ziwei Zhou, Xuan Liu, Xuejun Zhang, Shupeng Wen, Huan Hua, Zhenzhen Wang, Zheng Xu, Yu Lu, Fuxu Wang
Summary: Rapid natural killer (NK) cell reconstitution in the early stages of allogeneic stem cell transplantation (allo-HSCT) has protective effects on non-relapse mortality (NRM) and survival. Factors influencing early NK cell reconstitution in T cell-replete HSCT remain unclear. This study also found that rapid NK cell reconstitution is associated with lower rates of CMV reactivation and acute GVHD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Richard J. Lin, Harold K. Elias, Marcel R. M. van den Brink
Summary: Older patients with hematologic malignancies are increasingly undergoing allogeneic hematopoietic cell transplantation, with aging-related thymic dysfunction and other aging hallmarks potentially impacting immune reconstitution post-transplantation. Mechanism-based therapeutic interventions are being discussed to address these issues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jiayu Wang, Meng Yuan, Guanghua Zhu, Runhui Wu, Chenguang Jia, Bin Wang, Jie Zheng, Jie Ma, Maoquan Qin, Sidan Li
Summary: This study analyzed the immune reconstitution of pediatric patients with aplastic anemia after hematopoietic stem-cell transplantation (HSCT) and found that early rapid immune reconstitution is a good predictor of clinical prognosis in children with AA.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Immunology
Anna Soderstrom, Sofie Vonlanthen, Kerstin Jonsson-Videsater, Stephan Mielke, Hannes Lindahl, Johan Torlen, Michael Uhlin
Summary: This study found that measuring TREC levels can predict the prognosis of adult AML patients after bone marrow transplantation, especially overall survival. Lower TREC levels were associated with viral infections and CMV reactivation. KREC levels were not associated with clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dina Leth Moller, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengelov, Anders Elm Pedersen, Lars Peter Ryder, Klaus Muller
Summary: This study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Medicine, General & Internal
Martina Hinterleitner, Clemens Hinterleitner, Elke Malenke, Birgit Federmann, Ursula Holzer, Martin Mueller, Wolfgang A. Bethge, Stefan Wirths
Summary: Reconstitution of immune cells after stem cell transplantation takes place in different stages. This study investigated the formation of new B cells in patients who received haploidentical stem cell transplantation with CD3 and CD19 depletion. It was found that antibody-secreting cells (ASC) reconstituted very early, before the detection of naive and memory B cells.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Moniek A. de Witte, Anke Janssen, Klaartje Nijssen, Froso Karaiskaki, Luuk Swanenberg, Anna van Rhenen, Rick Admiraal, Lotte van der Wagen, Monique C. Minnema, Eefke Petersen, Reinier A. P. Raymakers, Kasper Westinga, Trudy Straetemans, Constantijn J. M. Halkes, Jaap-Jan Boelens, Jurgen Kuball
Summary: A multicenter study evaluated the outcome of alpha beta T-cell depleted allogeneic hematopoietic stem cell transplantation in adults, with only 26% developing aGVHD grades 2-4 within 100 days and a low incidence of cGVHD after 2 years. Prophylactic donor lymphocyte infusion improved the condition of some patients.
Article
Immunology
Clara Sattler, Petra Hoffmann, Philipp Yorck Herzberg, Daniela Weber, Barbara Holler, Ute Fehn, Annelie Plentz, Philipp Beckhove, Julia Winkler, Matthias Edinger, Wolfgang Herr, Ernst Holler, Daniel Wolff
Summary: A retrospective study analyzed predictors of immune response to primary vaccination in alloHSCT patients, showing that a majority of patients achieved protective titers to DTaP-Hib-IPV vaccine, but some patients had inadequate immune response.
Letter
Oncology
Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W. Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Gerber, Michele Zimmerman, Joseph A. Mierski, Shin Mineishi, Hong Zheng
Summary: This study investigates the impact of post-transplant cyclophosphamide (PTCy) on immune reconstitution post-allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a focus on T cells. The results show that PTCy significantly delays T cell reconstitution and affects T cell subsets, increasing regulatory T cells (Treg) and reducing naive T cells. It also leads to the upregulation of inhibitory receptors on CD4(+) and CD8(+) T cells, resulting in less functional CD8 T cells. The findings provide critical information for understanding the mechanism of PTCy's effect on immune reconstitution and optimizing clinical practices.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Biology
Hany Elmariah, Claudio G. Brunstein, Nelli Bejanyan
Summary: Allogeneic HCT is the only potential curative therapy for hematologic diseases, but patients are profoundly immunocompromised initially. Immune reconstitution after HCT, especially with alternative donors like haploidentical and umbilical cord blood, can improve access to treatment. Despite challenges, interventions such as antimicrobial prophylaxis and graft manipulation are available to mitigate risks during the immunocompromised period.
Review
Immunology
Jonathan Bordat, Sebastien Maury, Mathieu Leclerc
Summary: Allo-HSCT recipients are highly vulnerable to COVID-19 due to immunodeficiency, and changes in clinical practice have been implemented to reduce the risk. mRNA vaccines have shown effectiveness in preventing severe forms of the disease, but Allo-HSCT recipients may have a poor response to vaccination. Challenges include adapting vaccine protection to emerging variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Sarah Jungius, Franziska C. Adam, Kerstin Grosheintz, Michael Medinger, Andreas Buser, Jakob R. Passweg, Joerg P. Halter, Sara C. Meyer
Summary: Myelofibrosis (MF) is a rare hematopoietic stem cell disorder. Allogeneic hematopoietic cell transplantation (HCT) is a potential curative therapy for advanced MF, but MF patients have delayed engraftment compared to AML patients, leading to complications. This study investigated engraftment dynamics in MF patients and found that delayed neutrophil and platelet engraftment in MF is related to both host and treatment-related factors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Julia Teixeira Cottas de Azevedo, Thalita Cristina de Mello Costa, Keli Cristina Lima, Thiago Trovati Maciel, Patricia Vianna Bonini Palma, Luiz Guilherme Darrigo-Junior, Carlos Eduardo Setanni Grecco, Ana Beatriz P. L. Stracieri, Juliana Bernardes Elias, Fabiano Pieroni, Renato Luiz Guerino-Cunha, Ana Cristina Silva Pinto, Gil Cunha De Santis, Dimas Tadeu Covas, Olivier Hermine, Belinda Pinto Simoes, Maria Carolina Oliveira, Kelen Cristina Ribeiro Malmegrim
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for sickle cell disease (SCD). However, its effects on SCD pathophysiology are not fully understood. HSCT can normalize hematological parameters and decrease hemolysis in SCD patients, but systemic inflammation may persist for at least five years after transplantation, indicating that allo-HSCT does not equally affect all aspects of SCD pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Mobil Akhmedov, Galina Klyasova, Larisa Kuzmina, Elena Parovichnikova
Summary: This study aimed to analyze the rate and etiology of recurrent bloodstream infection (BSI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients. The results showed that recurrent BSI is rarely caused by the same pathogen, therefore empirical antimicrobial therapy should not be based solely on previous BSI data.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Review
Immunology
Asim Saha, Bruce R. Blazar
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for hematological malignancies. However, conventional allo-HSCT methods have adverse effects and can lead to graft-versus-host-disease. Recent developments in targeted radiotherapy and antibody-based conditioning show promise in improving the outcomes of allo-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Oncology
Andreas Glenthoj, Lasse H. Jakobsen, Mads Emil Bjorn, Christian B. Poulsen, Henrik Sengelov, Marianne T. Severinsen, Kristian Qvist, Ulrik M. Overgaard, Syed A. Ahmad, Annika Rewes, Ingolf Molle, Casper N. Strandholdt, Annette R. Kodahl, Jesper Ryg, Christian Brieghel, Isik S. Johansen, Karina Kannik, Soren Jensen-Fangel, Lothar Wiese, Ole Kirk, Michael R. Clausen, Marie Helleberg, Henrik Frederiksen
Article
Biophysics
Helene Jeppesen, Katrine Kielsen, Volkert Siersma, Jens Lindegaard, Hanne Olsen Julian, Steffen Heegaard, Henrik Sengelov, Klaus Muller
Summary: This nationwide single-centre study investigated the incidence and risk factors for ocular graft-versus-host disease (oGVHD) and dry eye disease (DED) in children receiving allogeneic haematopoietic stem cell transplantation (HSCT). The study found a relatively high incidence of oGVHD and DED after HSCT, with the use of Busulfan and malignant disease being identified as risk factors. Younger recipient age was associated with a reduced risk of DED. The study highlights the importance of ophthalmic examinations before and after HSCT to diagnose and treat these complications.
BONE MARROW TRANSPLANTATION
(2022)
Article
Hematology
Sarah Weischendorff, Henrik Sengelov, Anders Juul, Claus H. Nielsen, Lars P. Ryder, Katrine Kielsen, Klaus Mueller
Summary: The study found that high levels of IGF-1 and IGFBP-3 are associated with faster reconstitution of different blood cell populations after HSCT, including reticulocytes, thrombocytes, lymphocytes, neutrophil engraftment time, and circulating natural killer cells.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Immunology
Christopher J. A. Duncan, Morten K. Skouboe, Sophie Howarth, Anne K. Hollensen, Rui Chen, Malene L. Borresen, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Catherine F. Hatton, Frederik F. Staeger, Mette K. Andersen, John Whittaker, Soren R. Paludan, Sofie E. Jorgensen, Martin K. Thomsen, Jacob G. Mikkelsen, Carsten Heilmann, Daniela Buhas, Nina F. Obro, Jakob T. Bay, Hanne Marquart, M. Teresa de la Morena, Joseph A. Klejka, Matthew Hirschfeld, Line Borgwardt, Isabel Forss, Tania Masmas, Anja Poulsen, Francisco Noya, Guy Rouleau, Torben Hansen, Sirui Zhou, Anders Albrechtsen, Reza Alizadehfar, Eric J. Allenspach, Sophie Hambleton, Trine H. Mogensen
Summary: This study investigated five children from Greenland, Canada, and Alaska who carried a homozygous IFNAR2 gene variant, resulting in increased vulnerability to viral infections. This finding highlights the essential role of Type I interferons in viral immunity and suggests the need for further population screening studies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Signe Modvig, Rasmus Wernersson, Nina Friesgaard obro, Lars Ronn Olsen, Claus Christensen, Susanne Rosthoj, Matilda Degn, Gitte Wullf Jurgensen, Hans O. Madsen, Birgitte Klug Albertsen, Peder Skov Wehner, Steen Rosthoj, Henrik Lilljebjorn, Thoas Fioretos, Kjeld Schmiegelow, Hanne Vibeke Marquart
Summary: The study showed that a CD34-negative immunophenotype is considered a good prognostic factor in BCP-ALL patients, while high CD34 expression is associated with poor therapy response and an altered gene expression profile reminiscent of migrating cancer stem-like cells.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Stavroula Anastasopoulou, Arja Harila-Saari, Bodil Als-Nielsen, Mats Anders Eriksson, Mats Heyman, Inga Maria Johannsdottir, Hanne Vibeke Marquart, Riitta Niinimaki, Cornelis Jan Pronk, Kjeld Schmiegelow, Goda Vaitkeviciene, Maria Thastrup, Susanna Ranta
Summary: CNS involvement increases the risk of CNS toxicity, seizures, and PRES in children with ALL.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Marianne Helenius, Goda Vaitkeviciene, Jonas Abrahamsson, Olafur Gisli Jonsson, Bendik Lund, Arja Harila-Saari, Kim Vettenranta, Sirje Mikkel, Martin Stanulla, Elixabet Lopez-Lopez, Esme Waanders, Hans O. Madsen, Hanne Vibeke Marquart, Signe Modvig, Ramneek Gupta, Kjeld Schmiegelow, Rikke Linnemann Nielsen
Summary: This study investigated the variation in white blood cell count (WBC) in acute lymphoblastic leukemia (ALL) and the impact of host genome variants. The results showed that host genome variants do not strongly influence WBC across all subsets of ALL.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Immunology
Dina Leth Moller, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengelov, Anders Elm Pedersen, Lars Peter Ryder, Klaus Muller
Summary: This study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Immunology
Sara Bohnstedt Morup, Lusine Nazaryan-Petersen, Migle Gabrielaite, Joanne Reekie, Hanne Marquart, Hans Jakob Hartling, Rasmus L. Marvig, Terese L. Katzenstein, Tania N. Masmas, Jens Lundgren, Daniel D. Murray, Marie Helleberg, Line Borgwardt
Summary: This study suggests that reassessing WES/WGS data from patients with suspected PID may lead to improved diagnostic rates. Reasons for the potential gain in diagnosis include expanding the gene panel, adding structural variant analysis, and improved knowledge of genotype-phenotype correlations.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Thastrup, Hanne Vibeke Marquart, Kjeld Schmiegelow
Summary: Despite the good prognosis of acute lymphoblastic lymphoma in children and adolescents, involvement of the central nervous system (CNS) remains a therapeutic challenge. The current method for detecting CNS involvement has low sensitivity, while flow cytometric analysis of cerebrospinal fluid (CSF) offers a novel and sensitive approach. Prospective studies have shown that flow cytometry detects CNS involvement at a higher rate than conventional methods and is particularly sensitive in detecting low-level CNS disease. Flow cytometry-detected CNS involvement is linked to a higher risk of relapse and poor outcomes in childhood ALL.
Article
Hematology
Frederikke Schierbeck, Jann Mortensen, Niels S. Andersen, Lone S. Friis, Brian Kornblit, Soren L. Petersen, Ida Schjodt, Henrik Sengelov
Summary: The study aimed to evaluate the validity of the HCT-CI and pulmonary comorbidity in predicting NRM and OS after HCT. The results showed that both the PCS and HCT-CI had predictive value for OS, while only the PCS was significant for predicting NRM. Pulmonary function was found to be a strong predictor of 2-year OS and NRM after HCT.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Letter
Immunology
Maria Anna Bruusgaard-Mouritsen, Tania Masmas, Line Borgwardt, Lusine Nazaryan-Petersen, Carsten Heilmann, Hans O. Madsen, Hanne Vibeke Marquart
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Rabiah Fardoos, Claus Christensen, Nina Friesgaard Obro, Ulrik Malthe Overgaard, Bodil Als-Nielsen, Hans Ole Madsen, Hanne Vibeke Marquart
Summary: Next-generation sequencing (NGS) methods have been introduced for immunoglobulin (IG)/T-cell receptor (TR) gene rearrangement analysis in acute lymphoblastic leukemia (ALL) and lymphoma (LBL). NGS methods offer faster and more sensitive approaches, but it is unclear if low-density gene rearrangements represent minor subpopulations of malignant cells or background rearrangements in normal cells.
Meeting Abstract
Biophysics
F. Schierbeck, N. S. Andersen, L. S. Friis, B. T. Kornblit, S. L. Petersen, I. Schjodt, H. Sengelov
BONE MARROW TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Rebecka Svanberg, Cameron MacPherson, Adrian Zucco, Rudi Agius, Tereza Faitova, Michael Asger Andersen, Caspar da Cunha-Bang, Lars Klingen Gjaerde, Maria Elizabeth Engel Moller, Patrick Terrence Brooks, Birgitte Lindegaard, Adin Sejdic, Zitta Barrella Harboe, Anne Ortved Gang, Ditte Stampe Hersby, Christian Brieghel, Susanne Dam Nielsen, Daria Podlekareva, Annemette Hald, Jakob Thaning Bay, Hanne Marquart, Jens Lundgren, Anne-Mette Lebech, Marie Helleberg, Carsten Utoft Niemann, Sisse Rye Ostrowski
Summary: We found impairments in innate immune response pathways at the time of COVID-19 hospitalization that are associated with subsequent disease severity. However, these impairments were transient in those who were discharged from the hospital, indicating functional and cellular immune reconstitution. Additionally, we propose a stimulated immune response signature for predicting the risk of developing severe or critical COVID-19 disease at the time of hospitalization, which needs to be validated in larger cohorts.
COMMUNICATIONS MEDICINE
(2022)
