Intrinsic protein disorder in histone lysine methylation

DisCons: a novel tool to quantify and classify evolutionary conservation of intrinsic protein disorder

(2015) Mihaly Varadi et al.   BMC BIOINFORMATICS

The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting

(2015) Agnes Tantos et al.   Expert Review of Proteomics

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting histone lysine methylation in cancer

(2015) John McGrath et al.   PHARMACOLOGY & THERAPEUTICS

Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding

(2015) Munehito Arai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

(2015) Petr Tesina et al.   Nature Communications

Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential

(2015) Aravinda Kuntimaddi et al.   Cell Reports

The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV

(2014) M. J. Murai et al.   BLOOD

Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia

(2014) K.  ermakova et al.   CANCER RESEARCH

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

MobiDB 2.0: an improved database of intrinsically disordered and mobile proteins

(2014) Emilio Potenza et al.   NUCLEIC ACIDS RESEARCH

A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE)

(2014) Tsung-Jung Wu et al.   Database-The Journal of Biological Databases and Curation

Multisteric Regulation by Structural Disorder in Modular Signaling Proteins: An Extension of the Concept of Allostery

(2013) Peter Tompa   CHEMICAL REVIEWS

Molecular Pathways: Protein Methyltransferases in Cancer

(2013) R. A. Copeland   CLINICAL CANCER RESEARCH

In focus: MLL-rearranged leukemia

(2013) J de Boer et al.   LEUKEMIA

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

The eukaryotic linear motif resource ELM: 10 years and counting

(2013) Holger Dinkel et al.   NUCLEIC ACIDS RESEARCH

SET for life: biochemical activities and biological functions of SET domain-containing proteins

(2013) Hans-Martin Herz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Long-Range Interactions in Nonsense-Mediated mRNA Decay Are Mediated by Intrinsically Disordered Protein Regions

(2012) Lajos Kalmar et al.   JOURNAL OF MOLECULAR BIOLOGY

Discrete Molecular Dynamics: An Efficient And Versatile Simulation Method For Fine Protein Characterization

(2012) David Shirvanyants et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

(2012) Jing Huang et al.   NATURE

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

(2012) Pamela Zhang et al.   NUCLEIC ACIDS RESEARCH

Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks

(2012) Martin H. Schaefer et al.   NUCLEIC ACIDS RESEARCH

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

VAPC, an Human Endogenous Inhibitor for Hepatitis C Virus (HCV) Infection, Is Intrinsically Unstructured but Forms a “Fuzzy Complex” with HCV NS5B

(2012) Shaveta Goyal et al.   PLoS One

Protein disorder—a breakthrough invention of evolution?

(2011) Avner Schlessinger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Synergistic folding of two intrinsically disordered proteins: searching for conformational selection

(2011) Debabani Ganguly et al.   Molecular BioSystems

The relationship between proteome size, structural disorder and organism complexity

(2011) Eva Schad et al.   GENOME BIOLOGY

A lysine-rich region in Dot1p is crucial for direct interaction with H2B ubiquitylation and high level methylation of H3K79

(2010) Seunghee Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low-complexity regions within protein sequences have position-dependent roles

(2010) Alain Coletta et al.   BMC Systems Biology

Automated minimization of steric clashes in protein structures

(2010) Srinivas Ramachandran et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

ANCHOR: web server for predicting protein binding regions in disordered proteins

(2009) Z. Dosztanyi et al.   BIOINFORMATICS

Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins

(2009) Hedi Hegyi et al.   PLoS Computational Biology

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Intrinsic disorder explains diverse nuclear roles of chromatin remodeling proteins

(2008) Kuljeet Singh Sandhu   JOURNAL OF MOLECULAR RECOGNITION

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Ab Initio Folding of Proteins with All-Atom Discrete Molecular Dynamics

(2008) Feng Ding et al.   STRUCTURE