Journal
DYES AND PIGMENTS
Volume 170, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2019.107664
Keywords
Single NM laser; Photothermal therapy; Photodynamic therapy; Combination therapy
Funding
- National Natural Science Foundation of China [21602112, 21674048, 21574064]
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Developing single wavelength laser triggered organic nanoplatforms for combined photothermal therapy (PTT)/photodynamic therapy (PDT) is a great prospect for biomedicine. However, most of organic nanoparticles were prepared by nanoprecipitation method, which have the potential issues of nanopartides dissociation. In this work, a novel amphiphilic semiconducting oligomer DPP-BT-PEG which composed of a hydrophobic organic bacicbone and hydrophilic PEG side chains was designed and prepared. Due to the amphiphilic characteristic of DPP-BT-PEG, ideal nanoagents DPP-BT-PEG NPs were self-assembled by dissolving the amphiphilic molecule in water, which exhibited outstanding water-solubility, good biocompatibility, superb photostability, and excellent structural stability. Notably, upon exposure to a single near-infrared (NIR) laser, these nanoagents can produce cytotoxic hyperthermia and ROS simultaneously for effective cancer treatment due to the combined effects of PTT and PDT. This study supplies a promising tactic to construct non-dissociated NIR-absorbing organic nanoplatforrns for combination cancer therapy, opening new dimension for biomedicine.
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