Journal
DIGESTION
Volume 101, Issue 1, Pages 38-45Publisher
KARGER
DOI: 10.1159/000504090
Keywords
Functional dyspepsia; Mucosa-associated microbiota; Streptococcus
Categories
Funding
- Japan Society for the Promotion of Science [17K09358, 16H05289, 16K09322]
- R&D Matching Funds on the Field for Knowledge Integration and Innovation by the National Agriculture and Food Research Organization
- Japanese Foundation for Research and Promotion of Endoscopy
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Background: Functional dyspepsia (FD) is associated with poor health-related quality of life. Recent evidence suggests that the main pathogenesis suspect is the gut mucosa-associated microbiota (MAM). However, little is known about the MAM in FD subjects. The aim of this study was to clarify the relationship between upper gastrointestinal symptoms in FD and the characteristics of the gastrointestinal MAM. Summary: Five mucosa samples from the upper gut (intraoral, mid-esophagus, gastric body, gastric antrum, and descending portion of the duodenum) were collected with a brush under endoscopic examination from FD and healthy control subjects. MAM profiles of each sample were analyzed by 16S-rRNA -V3-V4 gene sequences. Questionnaire was used to assess gastrointestinal symptoms in FD. Between FD and healthy control subjects, although the comparison of MAM alpha-diversity showed no significant differences, the structure of MAM (beta-diversity) was clearly different. Only the phylum Firmicutes was increased in FD compared to healthy control subjects in all sites of the upper gut. At the genus level, Streptococcus was significantly increased in all sites in the upper gut in FD. The relative abundance of Streptococcus was positively correlated with upper gastrointestinal symptoms in each upper gut group. Furthermore, the relative abundance of OTU 90 was positively correlated with upper gastrointestinal symptoms in all sites in the upper gut in FD. Key Messages: Streptococcus is a bacterium strongly correlated with upper gastrointestinal symptoms in FD.
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