Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression

Benzbromarone aggravates hepatic steatosis in obese individuals

(2018) Peng Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation

(2018) Ling Wang et al.   Cell Death & Disease

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)

(2018) Csörsz Nagy et al.   Jove-Journal of Visualized Experiments

Urethral proteomic analysis in ovariectomized mice administered 17β-oestradiol replacement therapy

(2017) Huey-Yi Chen et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Exposure of Pregnant Mice to Triclosan Causes Insulin Resistance via Thyroxine Reduction

(2017) Xu Hua et al.   TOXICOLOGICAL SCIENCES

Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

(2016) Yun Qian et al.   Journal of Neuroinflammation

Activation of PPAR  Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice

(2016) L. Zhou et al.   JOURNAL OF NEUROSCIENCE

Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models

(2015) Fang Chen et al.   DIABETOLOGIA

Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPAR 

(2015) G. Li et al.   Disease Models & Mechanisms

Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis

(2015) Chihiro Ebihara et al.   HUMAN MOLECULAR GENETICS

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

(2015) Hongyi Zhou et al.   JOURNAL OF LIPID RESEARCH

Diet rich in Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice

(2015) Pengfei Xu et al.   Nutrition & Metabolism

Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA

(2014) Junfeng Bi et al.   Cell Metabolism

Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy

(2014) L. Liu et al.   DIABETES

Molecular Mechanisms Underlying Fasting Modulated Liver Insulin Sensitivity and Metabolism in Male LipodystrophicBscl2/Seipin-Deficient Mice

(2014) Weiqin Chen et al.   ENDOCRINOLOGY

Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ

(2014) Libin Zhou et al.   HUMAN MOLECULAR GENETICS

Cinnamtannin D-1 Protects Pancreatic β-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress

(2014) Ting Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

(2013) T. Mezza et al.   DIABETES

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

DC260126: A Small-Molecule Antagonist of GPR40 that Protects against Pancreatic β-Cells Dysfunction in db/db Mice

(2013) Peng Sun et al.   PLoS One

Discovery of P1736, a Novel Antidiabetic Compound That Improves Peripheral Insulin Sensitivity in Mice Models

(2013) Jessy Anthony et al.   PLoS One

Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice

(2012) N. Shojima et al.   DIABETOLOGIA

Estrogen improves vascular function via peroxisome-proliferator-activated-receptor-γ

(2012) Vedat Tiyerili et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Increase of Anteroventral Periventricular Kisspeptin Neurons and Generation of E2-Induced LH-Surge System in Male Rats Exposed Perinatally to Environmental Dose of Bisphenol-A

(2011) Yinyang Bai et al.   ENDOCRINOLOGY

Seipin ablation in mice results in severe generalized lipodystrophy

(2011) X. Cui et al.   HUMAN MOLECULAR GENETICS

Seipin, adipogenesis and lipid droplets

(2011) Weihua Fei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

Seipinopathy: a novel endoplasmic reticulum stress-associated disease

(2008) Daisuke Ito et al.   BRAIN

PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function

(2008) Hideaki KANETO et al.   ENDOCRINE JOURNAL

In Vivoandin VitroStudies of a Functional Peroxisome Proliferator-activated Receptor γ Response Element in the Mousepdx-1Promoter

(2008) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY