The Present and Future of Novel Protein Degradation Technology

Treatment of Prostate Cancers and Kennedy’s Disease by PROTAC-Androgen Receptor Degradation

(2019) Robert B. Kargbo   ACS Medicinal Chemistry Letters

Targeted Protein Internalization and Degradation by ENDosome TArgeting Chimeras (ENDTACs)

(2019) Dhanusha A. Nalawansha et al.   ACS Central Science

Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges

(2019) Scott D. Edmondson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting tubulin-colchicine site for cancer therapy: inhibitors, antibody-drug conjugates and degraders

(2019) Yongtao Duan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New Promises to Cure Cancer and Other Genetic Diseases/Disorders: Epi-drugs Through Epigenetics

(2019) Yong-Tao Duan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm

(2018) Eric Valeur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

(2018) Xiaohui Zhang et al.   LEUKEMIA

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

(2018) Pingyuan Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

De-novo and acquired resistance to immune checkpoint targeting

(2017) Nicholas L Syn et al.   LANCET ONCOLOGY

Structural basis of PROTAC cooperative recognition for selective protein degradation

(2017) Morgan S Gadd et al.   Nature Chemical Biology

Secreted Tumor Antigens - Immune Biomarkers for Diagnosis and Therapy

(2017) Els Meeusen et al.   PROTEOMICS

Cancer Precision Medicine: From Cancer Screening to Drug Selection and Personalized Immunotherapy

(2017) Xiaolan Deng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras

(2016) Honorine Lebraud et al.   ACS Central Science

CRISPR-Cas9: a new and promising player in gene therapy

(2015) Lu Xiao-Jie et al.   JOURNAL OF MEDICAL GENETICS

Building the foundation for genomics in precision medicine

(2015) Samuel J. Aronson et al.   NATURE

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Eosinophil Cytokines, Chemokines, and Growth Factors: Emerging Roles in Immunity

(2014) Francis Davoine et al.   Frontiers in Immunology

Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry

(2011) Johan Gabrielsson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Emerging role of gefitinib in the treatment of non-small-cell lung cancer (NSCLC)

(2010) Marcello Tiseo   Drug Design Development and Therapy

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

(2008) Ashley R. Schneekloth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS