Article
Multidisciplinary Sciences
Tim C. van Smaalen, Danielle M. H. Beurskens, Jasper J. H. F. M. Kox, Rasheendra Polonia, Rein Vos, Hans Duimel, Willine J. van de Wetering, Carmen Lopez-Iglesias, Chris P. Reutelingsperger, L. W. Ernest van Heurn, Carine J. Peutz-Kootstra, Gerry A. F. Nicolaes
Summary: Extracellular histones are released in warm ischemia and the resulting damage can be prevented by blocking histone release. The release of extracellular histones in patients receiving a renal transplant is associated with worse graft outcome. The findings suggest that targeting histones may be beneficial in preventing renal injury during transplantation.
Review
Biochemistry & Molecular Biology
Christina Bogensperger, Julia Hofmann, Franka Messner, Thomas Resch, Andras Meszaros, Benno Cardini, Annemarie Weissenbacher, Rupert Oberhuber, Jakob Troppmair, Dietmar ofner, Stefan Schneeberger, Theresa Hautz
Summary: Transplantation is limited by the shortage of healthy donor organs, but ex situ machine perfusion has the potential to expand the donor pool. Mesenchymal stem cells are considered as a tool with the potential to improve organs, but clinical benefits have not been conclusively demonstrated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Multidisciplinary Sciences
David J. J. Glass
Summary: Senescent cells in skeletal muscle promote inflammation and hinder regeneration, potentially causing harmful changes in aged muscle.
Article
Biochemistry & Molecular Biology
Joris Blondeel, Nicholas Gilbo, Veerle Heedfeld, Tine Wylin, Louis Libbrecht, Ina Jochmans, Jacques Pirenne, Hannelie Korf, Diethard Monbaliu
Summary: During normothermic machine perfusion (NMP), livers procured after warm ischemia (WI) exhibit a distinct innate immune response compared to directly procured (DP) livers. The cytokine profile in WI livers shifts towards an anti-inflammatory phenotype during NMP and whole blood (WB) reperfusion, while pro-apoptotic signaling is stronger during NMP. WB reperfusion results in a blunted cytokine release in livers, suggesting a reconditioning effect of NMP, regardless of ischemic damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Afsaneh Asgari Taei, Pariya Khodabakhsh, Sanaz Nasoohi, Maryam Farahmandfar, Leila Dargahi
Summary: It is well known that the therapeutic effects of transplanted mesenchymal stem cells (MSCs) in ischemic stroke are not due to cell replacement, but rather the secretion of bioactive molecules. The secretome of MSCs, which includes growth factors, cytokines, and extracellular vesicles, plays a crucial role in neuroprotection. The application of secretome derivatives, such as conditioned medium or purified extracellular vesicles, has shown significant advantages over MSC transplantation in stroke treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Baraa Noueihed, Jose Carlos Rivera, Rabah Dabouz, Penelope Abram, Samy Omri, Isabelle Lahaie, Sylvain Chemtob
Summary: The study demonstrates that MSCs can inhibit aberrant NV and reduce pathological levels of inflammatory factors in the ischemic retina by restoring neuronal Sema3E levels, providing a promising opportunity for stem cell therapy in ocular degenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Zihan Ling, Kentaro Noda, Brian L. Frey, Michael Hu, Shierly W. Fok, Lloyd M. Smith, Pablo G. Sanchez, Xi Ren
Summary: This study developed a bioorthogonal strategy to selectively capture and identify newly synthesized glycoproteins during EVLP, revealing specific proteomic signatures associated with warm ischemic injury in donor lung grafts. These signatures have high biological relevance to ischemia-reperfusion injury, validating the robustness of the presented approach.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lulu Liu, Lu Qiu, Yaqian Zhu, Lei Luo, Xinpei Han, Mingwu Man, Fuguang Li, Maozhi Ren, Yadi Xing
Summary: Regeneration is the process of repairing and replacing lost tissues and organs in organisms. Stem cells play a crucial role in animal and plant regeneration, with developmental processes involving totipotent, pluripotent, and unipotent stem cells. Stem cells and their products have diverse applications in agriculture, animal husbandry, environmental protection, and regenerative medicine. This review explores the similarities and differences in animal and plant tissue regeneration, as well as the regulation of regeneration through signaling pathways and key genes, aiming to provide insights for practical applications in agriculture and human organ regeneration, and to expand the future application of regeneration technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Beverly Brooks, Dominique Ebedes, Ahsan Usmani, Joaquin Vega Gonzales-Portillo, Daniel Gonzales-Portillo, Cesario Borlongan
Summary: Ischemic brain injury is a major cause of death worldwide with limited treatment options. Stem cell-based regenerative therapies, specifically mesenchymal stromal cells, show promise in stroke treatment, but further research is needed to fully understand their cell function.
Review
Biochemistry & Molecular Biology
Emilia Manole, Cristina Niculite, Ioana Maria Lambrescu, Gisela Gaina, Octavian Ioghen, Laura Cristina Ceafalan, Mihail Eugen Hinescu
Summary: Macrophages play a crucial role in maintaining tissue homeostasis and repair, displaying heterogeneity in response to environmental cues. Their diverse functions as M1 and M2 phenotypes contribute to tissue damage and wound healing, emphasizing the importance of understanding their intervention in stem cell behavior and niche regulation for developing novel therapeutic strategies in different diseases.
Article
Gastroenterology & Hepatology
Cambrian Y. Liu, Nandini Girish, Marie L. Gomez, Philip E. Dube, M. Kay Washington, Benjamin D. Simons, D. Brent Polk
Summary: In this study, it was found that a large squamous epithelium called squamous neo-epithelium of the colon (SNEC) exists near the anus during colitis. Squamous cells from the anus can migrate into the ulcerated colon and establish a permanent epithelium with crypt-like morphology. These squamous cells originate from a small transition zone outside the border of colonic and anal epithelium. Further research on these cells may provide new approaches for directing mucosal healing in inflammation and disease.
Review
Biochemistry & Molecular Biology
Reed Berlet, Stefan Anthony, Beverly Brooks, Zhen-Jie Wang, Nadia Sadanandan, Alex Shear, Blaise Cozene, Bella Gonzales-Portillo, Blake Parsons, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Cesario Borlongan
Summary: Combining stem cell transplantation with rehabilitation therapy presents a promising approach in treating stroke, with potential for better functional outcomes for patients. This comprehensive review assesses the advantages and disadvantages of using this combined therapy to mitigate the devastating effects of stroke.
Article
Medicine, General & Internal
Mehmet Burak Yalcin, Ejder Saylav Bora, Muemin Alper Erdogan, Adem Cakir, Oytun Erbas
Summary: This study investigated the role of syndecan-1 and heat shock protein 70 (HSP-70) in mediating the regenerative effects of adipose-derived mesenchymal stem cells (ADSCs) on peripheral nerves. The results showed that ADSCs could secrete syndecan-1 and HSP-70 in response to stress conditions, and ADSC treatment significantly improved functional recovery and nerve regeneration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Tingting He, Guo-Yuan Yang, Zhijun Zhang
Summary: Stroke is a major cause of death and disability, and astrocytes play a complex role in response to ischemic stroke, both beneficial and detrimental. Reactive astrocytes provide neuroprotection but also contribute to neuroinflammation and brain edema. Understanding the interaction between astrocytes and other cells is crucial for the potential implications in ischemic stroke treatment.
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)