Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jingjing He, Fangyan Chen, Sitong Wan, Yongting Luo, Junjie Luo, Shuli He, Daizhan Zhou, Peng An, Ping Zeng
Summary: Antioxidant minerals such as zinc, copper and selenium have important roles in maintaining redox balance in the body. This study aimed to investigate the relationship between these minerals and type 2 diabetes mellitus (T2DM) in Chinese populations. The results showed a negative association between serum zinc and copper concentrations and T2DM, while no association was found for serum selenium. Adequate intake of antioxidant minerals is emphasized for T2DM prevention in the Chinese population.
Review
Medicine, General & Internal
Kosmas Margaritis, Georgia Margioula-Siarkou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Eleni P. Kotanidou, Athanasios Christoforidis, Evangelos Pavlou, Assimina Galli-Tsinopoulou
Summary: Type 1 diabetes mellitus (T1DM) is a metabolic disorder with increasing incidence in children. This study found that 7 microRNAs have contrasting expression in T1DM patients, with 3 of them potentially serving as diagnostic biomarkers.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Mark J. O'Connor, Philip Schroeder, Alicia Huerta-Chagoya, Paula Cortes-Sanchez, Silvia Bonas-Guarch, Marta Guindo-Martinez, Joanne B. Cole, Varinderpal Kaur, David Torrents, Kumar Veerapen, Niels Grarup, Mitja Kurki, Carsten F. Rundsten, Oluf Pedersen, Ivan Brandslund, Allan Linneberg, Torben Hansen, Aaron Leong, Jose C. Florez, Josep M. Mercader
Summary: GWAS using a recessive model identifies new loci associated with type 2 diabetes, including variants with larger effects.
Article
Biochemistry & Molecular Biology
N. Srinivasa Rao, G. J. Naga Raju, M. K. Tiwari, B. G. Naidu, P. Sarita
Summary: The study analyzed 158 serum samples of newly diagnosed type 2 diabetes patients and control subjects using Synchrotron Radiation X-ray Fluorescence (SRXRF) technique. The results showed a significant alteration in the concentrations of several elements in the patient group compared to the control group, which might have led to ineffective uptake of insulin and interference with glucose homeostasis through oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Endocrinology & Metabolism
Juan Juan, Yiying Sun, Yumei Wei, Shuang Wang, Geng Song, Jie Yan, Pengxiang Zhou, Huixia Yang
Summary: A systematic review and meta-analysis found that women diagnosed with gestational diabetes mellitus (GDM) according to the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria have a higher risk of developing type 2 diabetes mellitus (T2DM) and prediabetes. The risk of T2DM in GDM women increases with longer follow-up duration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Jingxuan Lian, Jianfang Fu
Summary: Pioglitazone can significantly improve liver histological performance and insulin sensitivity, as well as significantly reduce fasting blood glucose, glycosylated hemoglobin, plasma AST, ALT and other liver biological indicators. Long-term studies are still needed to verify its efficacy and safety due to the lack of relevant randomized controlled trials and short intervention times.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Feifei Zhou, Nannan Du, Lulin Zhou, Chenxi Wang, He Ren, Qiang Sun
Summary: This meta-analysis demonstrates that sotagliflozin has an acceptable safety profile in patients with diabetes, with adverse events including genital mycotic infection, related-to-acidosis events, diarrhea, volume depletion, and severe nocturnal hypoglycemia events. The subgroup analysis of sotagliflozin dosage is of great clinical significance for guiding the use of sotagliflozin in patients with diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Review
Biochemistry & Molecular Biology
Athanasia Athanasaki, Konstantinos Melanis, Ioanna Tsantzali, Maria Ioanna Stefanou, Sofia Ntymenou, Sotirios G. Paraskevas, Theodosis Kalamatianos, Eleni Boutati, Vaia Lambadiari, Konstantinos Voumvourakis, George Stranjalis, Sotirios Giannopoulos, Georgios Tsivgoulis, George P. Paraskevas
Summary: Alzheimer's disease is the most common type of dementia and is closely linked to type 2 diabetes mellitus through various molecular pathways.
Article
Cardiac & Cardiovascular Systems
Yan-Yan Li, Hui Wang, Yang-Yang Zhang
Summary: The meta-analysis showed a significant association between NEUROD1 gene Ala45Thr polymorphism and T2DM, especially in the Asian population, with Thr45 allele carriers being more susceptible to T2DM.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin
Summary: This study systematically reviews and estimates the association between type 2 diabetes mellitus (T2DM) and brain volumetric differences and atrophy. The results show that individuals with T2DM have smaller total and regional brain volumes, as well as greater brain atrophy over time. Meta-regression analysis suggests that diabetes-related brain volume differences start occurring in early adulthood, decrease with age, and increase with diabetes duration. These findings highlight the urgent need to develop interventions to reduce the risk of T2DM for brain health.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Summary: The study explores the relationship between plasma LRG1 level and urinary albumin excretion in patients with type 2 diabetes. The results show that there is a positive correlation between plasma LRG1 level and urinary albumin excretion, indicating that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Wenqi Fan, Haipeng Pang, Xiajie Shi, Jiaqi Li, Yimeng Wang, Shuoming Luo, Jian Lin, Haibo Yu, Yang Xiao, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou
Summary: This study identified the plasma-derived exosomal mRNA expression profiles of T1DM for the first time, suggesting that the identified DEMs may play a role in the pathogenesis of T1DM and have the potential to serve as biomarkers and therapeutic targets for T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Phoebe Loxton, Kruthika Narayan, Craig F. Munns, Maria E. Craig
Summary: This study found abnormal bone development and reduced bone mineral density in youth with type 1 diabetes through systematic review and meta-analysis using multiple modalities. Routine assessment of bone mineral density should be considered for all youth with type 1 diabetes.
Review
Cell & Tissue Engineering
Wenjun Zhu, Min Liang
STEM CELLS INTERNATIONAL
(2015)
Article
Dentistry, Oral Surgery & Medicine
Fuping Zhang, Qihong Qiu, Xiangchen Song, Yuting Chen, Juan Wu, Min Liang
JOURNAL OF PERIODONTOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Q. Qiu, F. Zhang, J. Wu, N. Xu, M. Liang
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Wenjun Zhu, Yuanyuan Tan, Qihong Qiu, Xiting Li, Zixian Huang, Yun Fu, Min Liang
ARCHIVES OF ORAL BIOLOGY
(2013)
Article
Endocrinology & Metabolism
Min Liang, Graham Russell, Philippa A. Hulley
JOURNAL OF BONE AND MINERAL RESEARCH
(2008)
Article
Cell Biology
Weiyan Mo, Haoyuan Luo, Juan Wu, Na Xu, Fuping Zhang, Qihong Qiu, Wenjun Zhu, Min Liang
JOURNAL OF MOLECULAR HISTOLOGY
(2020)
Article
Cell Biology
Weiyan Mo, Juan Wu, Qihong Qiu, Fuping Zhang, Haoyuan Luo, Na Xu, Wenjun Zhu, Min Liang
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Cell Biology
Haoyuan Luo, Wenjun Zhu, Weiyan Mo, Min Liang
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Orthopedics
Min Liang, Hannah R. Cornell, Nasim Zargar Baboldashti, Mark S. Thompson, Andrew J. Carr, Philippa A. Hulley
ADVANCES IN ORTHOPEDICS
(2012)
Article
Physiology
M Liang, E Ekblad, P Hellstrand, BO Nilsson
JOURNAL OF VASCULAR RESEARCH
(2004)