Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 58-59, Issue -, Pages 49-54Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2019.07.011
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Funding
- Stowers Institute for Medical Research
- March of Dimes
- National Institutes of Health (NIH) [R00GM114436, DP2GM132936, K22AI119017, R35GM133633]
- UCSD Division of Biological Sciences
- Pew Biomedical Scholars award
- Searle Scholars award
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Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA sequences versus the rest of the host genome) can both foster 'molecular arms races', in which genes on both sides of the conflict rapidly evolve due to bouts of adaptation and counter-adaptation. Importantly, a source of genetic novelty is needed to fuel these arms races. In this review, we highlight gene conversion as a major force in generating the novel alleles on which selection can act. Using examples from both intergenomic and intragenomic conflicts, we feature the mechanisms by which gene conversion facilitates the rapid evolution of genes in conflict.
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