Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling

Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression

(2014) Wei Gao et al.   Diabetes & Vascular Disease Research

Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal

(2014) Rui Du et al.   MOLECULAR BIOLOGY OF THE CELL

Glomerular structural-functional relationship models of diabetic nephropathy are robust in type 1 diabetic patients

(2014) M. Mauer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial–mesenchymal transition in renal tubular cells

(2013) Wei-Qing Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α

(2013) Keiichiro Matoba et al.   KIDNEY INTERNATIONAL

KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis

(2013) C. Huang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis

(2012) Xiuli Zhang et al.   CELLULAR SIGNALLING

Impact of the Hypoxia-Inducible Factor-1   (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy

(2012) H. F. Gu et al.   DIABETES CARE

Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes

(2012) M. Friederich Persson et al.   DIABETOLOGIA

PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis

(2012) Guo-Qing Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The pathogenic role of the renal proximal tubular cell in diabetic nephropathy

(2012) S. C. W. Tang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB

(2011) Marco Tafani et al.   CARCINOGENESIS

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

(2010) Imari Mimura et al.   Nature Reviews Nephrology

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

(2010) Lavinia Nardinocchi et al.   PLoS One

The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease

(2009) Tetsuhiro Tanaka et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Zinc supplementation partially prevents renal pathological changes in diabetic rats☆

(2009) Yunan Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

(2009) Shiren Sun et al.   KIDNEY INTERNATIONAL

The Effect of Zinc Supplements in Cystic Fibrosis Patients

(2008) S. Van Biervliet et al.   ANNALS OF NUTRITION AND METABOLISM

Causes and Consequences of Zinc Dyshomeostasis in Rats With Chronic Aldosteronism

(2008) Malay S Gandhi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Activation of Erk1/2 and Akt following unilateral ureteral obstruction

(2008) Ana B. Rodríguez-Peña et al.   KIDNEY INTERNATIONAL

Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy

(2008) Dhruv K Singh et al.   Nature clinical practice. Nephrology